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2'-Hydroxychalcone

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Identification
Molecular formula
C15H12O2
CAS number
608-20-6
IUPAC name
1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one
State
State
2'-Hydroxychalcone is typically found in a solid state at room temperature, usually as a crystalline powder.
Melting point (Celsius)
204.00
Melting point (Kelvin)
477.20
Boiling point (Celsius)
413.40
Boiling point (Kelvin)
686.50
General information
Molecular weight
224.25g/mol
Molar mass
224.2500g/mol
Density
1.2123g/cm3
Appearence

2'-Hydroxychalcone is a crystalline solid at room temperature. It generally appears as a light yellow powder or crystal. The compound is noted for its strong absorption in the UV region, which may influence its appearence depending on the purity and form (crystalline or powdered).

Comment on solubility

Solubility of 1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one

The solubility of 1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one, often referred to as chalcone, is an intriguing topic due to its structural characteristics and functional groups. This compound has shown variable solubility depending on the solvent used.

In General:

  • Polar Solvents: Chalcones typically display limited solubility in polar solvents such as water. This is attributed to their substantial aromatic character and the lack of strong polar functional groups to interact with water molecules.
  • Non-Polar Solvents: Conversely, chalcone is generally more soluble in non-polar solvents like benzene or hexane. Due to the hydrophobic nature of the aromatic rings, non-polar interactions play a key role in its solubility.
  • Exemplary Solvent: Ethanol is often a suitable solvent for chalcones, striking a balance between polar and non-polar characteristics, enhancing solubility in moderate amounts.

Furthermore, solubility can be influenced by factors such as temperature and the presence of other chemical species. For instance, heating the solution may increase solubility due to increased molecular motion. It’s also worth noting that the presence of salts or other solutes can disrupt hydrogen bonding and affect the overall solubility profile.

In summary, the solubility of 1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one is highly dependent on the nature of the solvent, making it an interesting compound for studies involving solvent interactions and organic synthesis.

Interesting facts

Interesting Facts about 1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one

This compound, commonly known as chalcone, has sparked interest in various scientific fields due to its intriguing properties and potential applications. Below are some engaging facts about 1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one:

  • Bioactivity: Chalcones are known for their wide range of biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. This makes them attractive candidates in pharmaceutical research.
  • Colorful Chemistry: The compound can exhibit varied color changes depending on its environment, which can be particularly useful in pH indicators and dyes.
  • Synthesis: Various synthetic routes have been developed to produce chalcones, often involving the condensation of aromatic aldehydes with acetophenones. This flexibility allows for a diverse range of substituted chalcones with tailored properties.
  • Natural Occurrence: Chalcones can also be found in nature, in plants such as artemisia and licorice. Their natural occurrence highlights their potential as herbal remedies and in traditional medicine.
  • Research Focus: Ongoing studies are exploring their role in cancer treatment, with some chalcones demonstrating potential in inhibiting tumor growth and proliferation.
  • Structure and Function: The unique structure of chalcones, with a conjugated double bond system, contributes to their ability to interact effectively with biological molecules, showcasing the importance of molecular design in drug discovery.

In summary, 1-(2-hydroxyphenyl)-3-phenyl-prop-2-en-1-one is not just a fascinating compound from a chemical perspective; it represents a bridge between chemistry and biology, underscoring the importance of interdisciplinary research in developing new therapeutic agents. As scientists continue to explore its properties, chalcones may hold the key to breakthroughs in various health-related fields.

Synonyms
DTXSID9061627
DTXCID5033709
2-Propen-1-one, 1-(hydroxyphenyl)-3-phenyl-
6'-hydroxychalcone
2\'-Hydroxychalcone
2a(2)-Hydroxychalcone
SCHEMBL126857
CHEMBL1867065
AETKQQBRKSELEL-UHFFFAOYSA-N
CMLD2_000189
NCGC00017803-04
NCGC00017803-05
PD029079
DB-021203