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1-(2-Phenylethyl)piperidine

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Identification
Molecular formula
C13H19N
CAS number
1473-39-8
IUPAC name
1-(2-phenylethyl)piperidine
State
State

At room temperature, 1-(2-Phenylethyl)piperidine is typically in a liquid state. The compound is an oily substance that can be handled under standard laboratory conditions, ensuring adequate ventilation due to its potential odor and volatility.

Melting point (Celsius)
-20.00
Melting point (Kelvin)
253.15
Boiling point (Celsius)
246.00
Boiling point (Kelvin)
519.15
General information
Molecular weight
189.30g/mol
Molar mass
189.3010g/mol
Density
0.9530g/cm3
Appearence

1-(2-Phenylethyl)piperidine appears as a colorless or pale yellow liquid. It may emit an odor, typical of amines, and it is often used in laboratory environments.

Comment on solubility

Solubility of 1-(2-phenylethyl)piperidine

1-(2-phenylethyl)piperidine is an intriguing organic compound when it comes to its solubility properties. Understanding its solubility is crucial as it influences various applications, particularly in pharmaceuticals and chemistry.

Key Factors Affecting Solubility

  • Polarity: The interplay of polar and nonpolar characteristics determines its solubility in various solvents. With a piperidine structure, the nitrogen atom introduces some polar character.
  • Hydrogen Bonding: The ability of the molecule to engage in hydrogen bonding can enhance solubility in polar solvents.
  • Chain Length: The length of the phenethyl side chain may affect the overall solubility in organic solvents.

General Solubility Insights

The solubility of 1-(2-phenylethyl)piperidine in common solvents can be summarized as follows:

  • Water: Typically low solubility due to its organic nature and relatively nonpolar regions.
  • Organic Solvents: More soluble in solvents like ethanol, acetone, and chloroform owing to its compatibility with nonpolar and moderately polar environments.

In conclusion, while 1-(2-phenylethyl)piperidine may exhibit limited solubility in water, its affinity for organic solvents makes it a versatile compound for various chemical applications and reactions. Remember, "the solubility of a compound is not just a simple yes or no; it’s a nuanced characteristic shaped by many factors!"

Interesting facts

Interesting Facts about 1-(2-phenylethyl)piperidine

1-(2-phenylethyl)piperidine is a fascinating compound that belongs to the class of piperidine derivatives, known for their unique properties and diverse applications. This compound has piqued the interest of both chemists and pharmacologists due to several reasons:

  • Layered Chemistry: The piperidine ring structure contributes significantly to the compound's chemical reactivity. By functionalizing this basic structure, scientists can create various derivatives with tailored properties.
  • Pharmacological Significance: Compounds like 1-(2-phenylethyl)piperidine are often studied for their potential therapeutic effects. They may act as intermediates or as the basis for developing drugs targeting central nervous system disorders.
  • Versatile Applications: This compound can also serve as a building block in synthesizing other complex organic molecules, making it valuable in both academic research and industrial settings.
  • Structure Activity Relationship (SAR): Understanding the relationship between the chemical structure and biological activity of this compound is crucial. Researchers often explore how different substituents on the piperidine ring influence its pharmacological properties.
  • Natural Occurrences: Some derivatives of piperidine can be found in nature. This connection to bioactivity prompts chemists to explore how modifications to the piperidine structure might enhance natural product synthesis.

Given its potential for innovation in medicinal chemistry and its intricate structure, 1-(2-phenylethyl)piperidine continues to be a compound of interest. As stated by many researchers, "The pursuit of understanding is never-ending, especially in the realm of organic compounds." This reflects the active exploration and continuous development surrounding this fascinating chemical entity.

Synonyms
1-Phenethylpiperidine
1-(2-Phenylethyl)piperidine
6949-43-5
332-14-9
Piperidine, 1-(2-phenylethyl)-
1-phenethyl-piperidine
1-Piperidino-2-phenylethane
N-(2-Phenylethyl)piperidine
PIPERIDINE, 1-PHENETHYL-
FMP-199
N-phenethylpiperidine
1-Piperidino-2-phenyl-aethan
phenethylpiperidine
EINECS 206-362-8
1-Piperidino-2-phenyl-aethan [German]
BRN 0137585
AI3-11531
CHEMBL75228
5TY7C52M7F
DTXSID5059822
DBDVAKGHPZJLTH-UHFFFAOYSA-
AC927
5-20-02-00064 (Beilstein Handbook Reference)
NSC-122975
UNII-5TY7C52M7F
SCHEMBL917609
1-(2-Phenylethyl)piperidine #
DTXCID3038646
BDBM50109389
AKOS006242111
1-(2-phenylethyl)piperidine hydriodide
NCGC00184305-01
NCGC00184305-02
AS-57452
CS-0451167
NS00029439
A11735
EN300-8588965
Z137504398