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Trifluoromethylphenylpiperazine derivative

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Identification
Molecular formula
C26H30F6N2
CAS number
137392-73-1
IUPAC name
1-[2-(trifluoromethyl)phenyl]-N-[[4-[[[2-(trifluoromethyl)phenyl]methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine
State
State
This compound is typically a solid at room temperature.
Melting point (Celsius)
68.10
Melting point (Kelvin)
341.20
Boiling point (Celsius)
320.10
Boiling point (Kelvin)
593.30
General information
Molecular weight
472.47g/mol
Molar mass
472.4720g/mol
Density
1.2600g/cm3
Appearence

This compound is typically presented as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[2-(trifluoromethyl)phenyl]-N-[[4-[[[2-(trifluoromethyl)phenyl]methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine

This compound exhibits unique solubility characteristics, largely influenced by its complex molecular structure. The presence of trifluoromethyl groups enhances its hydrophobicity, which often results in decreased solubility in polar solvents such as water. However, its solubility can be more favorable in non-polar or organic solvents.

Key factors affecting the solubility include:

  • Molecular Structure: The bulky bicyclo[2.2.2]octanyl moiety may hinder the interaction with solvent molecules.
  • Polarity: The balance between polar and non-polar functional groups plays a critical role in solubility behavior.
  • Interactions: Potential for intramolecular interactions that can influence solubility dynamics.

In summary, while 1-[2-(trifluoromethyl)phenyl]-N-[[4-[[[2-(trifluoromethyl)phenyl]methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine may have limited solubility in aqueous solutions, it might find better compatibility with organic solvents like dichloromethane or ethanol. Further studies are needed to fully understand its solubility profile and practical applications.

Interesting facts

Interesting Facts about 1-[2-(Trifluoromethyl)phenyl]-N-[[4-[[[2-(trifluoromethyl)phenyl]methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine

This compound is a fascinating example of modern medicinal chemistry, showcasing the intricate relationship between chemical structure and biological activity. The presence of the trifluoromethyl group is a notable feature, as it is often used to enhance the pharmacokinetic properties of pharmaceuticals. Here are some intriguing aspects of this compound:

  • Complex Structure: The compound contains a bicyclic structure, which contributes to its potential ability to interact with biological targets in unique ways.
  • Fluorine Chemistry: The introduction of fluorine atoms in organic molecules can significantly affect their lipophilicity, stability, and overall biological activity, making this compound a candidate for advanced therapeutic applications.
  • Biological Applications: Compounds with similar structures have been explored in the treatment of various conditions, including neurological disorders, where the modulation of neurotransmitter systems is crucial.
  • Chiral Centers: The presence of chiral centers may lead to different enantiomers of this compound, each potentially having distinct biological activities. This adds complexity to its evaluation as a drug candidate.

Moreover, research continues to uncover the roles that specific substitutions, such as the trifluoromethyl groups, play in enhancing selectivity and efficacy. As one expert stated, "The intricate dance of atoms and bonds can unlock doors to innovative treatments that were once thought impossible."
Understanding and manipulating such compounds are fundamental in the quest for new therapeutic agents that can address unmet medical needs.