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Rosuvastatin

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Identification
Molecular formula
C22H28FN3O6S
CAS number
287714-41-4
IUPAC name
1-[(20R)-7-(4-fluorophenyl)-17,20-dihydroxy-2,16,18-trimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxy-ethanone
State
State

At room temperature, Rosuvastatin is typically a solid in powder form. It is stable under standard conditions.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.20
Boiling point (Celsius)
627.30
Boiling point (Kelvin)
900.50
General information
Molecular weight
481.54g/mol
Molar mass
481.5390g/mol
Density
1.2470g/cm3
Appearence

Rosuvastatin is an off-white to white powder. It is not water soluble and is commonly provided in the form of rosuvastatin calcium for better solubility.

Comment on solubility

Solubility of 1-[(20R)-7-(4-fluorophenyl)-17,20-dihydroxy-2,16,18-trimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxy-ethanone

The solubility of the compound 1-[(20R)-7-(4-fluorophenyl)-17,20-dihydroxy-2,16,18-trimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxy-ethanone is influenced by its complex structure and the functional groups present within it. Understanding its solubility can be quite fascinating due to the following key considerations:

  • Polarity: The presence of multiple hydroxyl groups increases the polarity of the compound, suggesting possible solubility in polar solvents such as water.
  • Hydrophobic Character: The significant hydrophobic regions might limit solubility in aqueous environments, particularly at higher concentrations.
  • Solvent Compatibility: The compound could exhibit variable solubility in different organic solvents like ethanol, methanol, or DMSO, which are often used in chemical laboratories.
  • Temperature Effects: Solubility may also increase with temperature, as is common with many organic compounds, making warm solutions potentially more effective.

As stated in scientific literature, “The more complex the structure, the more factors that can influence solubility.” This compound's intricate arrangement and diverse functional groups make predicting its solubility behavior a challenging task. Researchers often conduct specific solubility tests to derive accurate data for practical applications.

Interesting facts

Interesting Facts about 1-[(20R)-7-(4-fluorophenyl)-17,20-dihydroxy-2,16,18-trimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxy-ethanone

This intriguing compound exhibits a complex structure, showcasing the incredible diversity and potential of organic chemistry. It belongs to a category of molecules known for their biological activity, with implications in various fields, including pharmacology and medicinal chemistry.

Key Highlights:

  • Structural Complexity: The compound features a unique pentacyclic framework, which makes it a fascinating subject for structural analysis and synthesis exploration.
  • Biological Significance: Compounds with similar structures are often investigated for their capacity to interact with biological targets, potentially leading to the development of new therapeutics.
  • Fluorine Atoms: The inclusion of a fluorophenyl group can significantly affect the compound's properties, including its ability to penetrate biological membranes, enhancing pharmacokinetics.
  • Chirality: With a specific stereocenter denoted as (20R), the compound's chirality may influence its biological activity, making stereochemistry a critical aspect of research in this area.
  • Potential Applications: Ongoing studies may reveal this compound's utility in treating diseases, showcasing the vital link between molecular structure and function.

In the realm of chemistry and drug discovery, the intricate design of molecules like this one demonstrates how modifying certain components can yield profound enhancements in desired properties. As stated by an eminent chemist, "The best way to predict the future is to invent it," a sentiment that resonates with the continuous exploration of compounds like this in the pursuit of groundbreaking medical advancements.

Overall, the study of such complex compounds is not just an academic exercise; it is a gateway to potential innovations and solutions in the ever-evolving landscape of science.