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Metoprolol

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Identification
Molecular formula
C15H25NO3
CAS number
37350-58-6
IUPAC name
1-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-(3-methoxypropylamino)propan-1-ol
State
State

At room temperature, Metoprolol is in a solid state, most commonly found as a white crystalline powder. When formulated into tablets, it may appear as either oval or round-shaped solid doses.

Melting point (Celsius)
120.50
Melting point (Kelvin)
393.65
Boiling point (Celsius)
393.15
Boiling point (Kelvin)
666.30
General information
Molecular weight
267.36g/mol
Molar mass
267.3640g/mol
Density
1.3000g/cm3
Appearence

Metoprolol is typically encountered as a white crystalline powder. It may not have any distinct odor and is usually supplied in solid form for pharmaceutical preparations. The powder dissolves in both water and alcohol.

Comment on solubility

Solubility Properties of 1-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-(3-methoxypropylamino)propan-1-ol

The solubility of 1-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-(3-methoxypropylamino)propan-1-ol can be described as follows:

  • Polar Nature: Given its structural components, particularly the hydroxyl (-OH) group and amino (-NH) group, the compound exhibits polar characteristics that favor solubility in polar solvents.
  • Water Solubility: It is likely to have moderate solubility in water due to the presence of the polar functional groups, allowing for hydrogen bonding.
  • Soluble in Organic Solvents: The presence of the benzodioxin moiety may enhance solubility in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).
  • pH Dependence: The solubility may be sensitive to pH changes, as certain functional groups could ionize, affecting overall solubility behavior.
  • Temperature Influence: Like many compounds, solubility can be temperature-dependent. Increased temperatures generally enhance solubility due to increased molecular motion.

In summary, the solubility characteristics of this compound are influenced by the interplay of its functional groups, polarities, and environmental conditions. It showcases the complexity of solubility in chemical compounds, which can significantly affect their application and behavior in various contexts.

Interesting facts

Interesting Facts about 1-(2,3-Dihydro-1,4-benzodioxin-3-yl)-2-(3-methoxypropylamino)propan-1-ol

This compound, with its complex structure, represents an intriguing intersection of organic chemistry and medicinal applications. Here are some noteworthy aspects:

  • Structural Diversity: The presence of a benzodioxin ring makes this compound unique, contributing to its potential biological activity. Benzodioxins are known for their multifunctionality, often utilized in designing drugs.
  • Biological Relevance: Compounds similar to this one have been studied for their pharmacological properties, including roles as inhibitors or modulators in various biochemical pathways.
  • Amine Functionalities: The incorporation of a 3-methoxypropylamino group may enhance the compound's bioavailability and interaction with biological targets, making it an important focus for drug development.
  • Research Potential: This compound paves the way for exploring its derivatives and analogs, which could offer new therapeutic options in treating diseases by modifying its functional groups.
  • Medicinal Chemistry: The strategic connectivity in this compound showcases the principles of medicinal chemistry, where small changes in structure can drastically alter biological activity.

Overall, 1-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-(3-methoxypropylamino)propan-1-ol represents a fascinating avenue for research, emphasizing the importance of understanding the structure-activity relationship in drug design.

Synonyms
7562-63-2
BRN 1434258
3250 I.S.
alpha-(1-((3-Methoxypropyl)amino)ethyl)-1,4-benzodioxan-2-methanol
1,4-BENZODIOXAN-2-METHANOL, alpha-(1-((3-METHOXYPROPYL)AMINO)ETHYL)-
2-(1-Idrossi-2-(gamma-metossipropylammino))propil-1,4-benzodiossano [Italian]
5-19-08-00553 (Beilstein Handbook Reference)
DTXSID10997058
2-(1-Idrossi-2-(gamma-metossipropylammino))propil-1,4-benzodiossano
1-(2,3-dihydro-1,4-benzodioxin-2-yl)-2-[(3-methoxypropyl)amino]propan-1-ol