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Clotrimazole nitrate

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Identification
Molecular formula
C16H15Cl2N3O4
CAS number
23593-75-1
IUPAC name
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone;nitrate
State
State

At room temperature, Clotrimazole nitrate exists as a solid, which makes it appropriate for use in powder formulations, often for pharmaceutical preparations such as creams and other topical solutions.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
480.78g/mol
Molar mass
480.7780g/mol
Density
1.6920g/cm3
Appearence

Clotrimazole nitrate is typically a white to slightly yellow crystalline powder. It is commonly used in pharmaceuticals, especially in antifungal medications. The powder form allows it to be easily formulated into various types of medications.

Comment on solubility

Solubility of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone nitrate

The solubility of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone nitrate tends to exhibit characteristics influenced by its unique chemical structure. Generally speaking, the solubility of this compound can be outlined as follows:

  • Polarity: The presence of the imidazolium group may enhance polarity, potentially increasing solubility in polar solvents like water.
  • Hydrogen Bonding: The imidazolium functional group is capable of hydrogen bonding, which can further facilitate dissolution in polar environments.
  • Interactions with Anions: The nitrate ion has good solubility in water, suggesting that the overall compound may also have reasonable solubility due to these ionic interactions.
  • Organic Solvents: Its solubility in organic solvents may vary, contingent on the solvent's miscibility with aromatic compounds.

When considering solubility, it is often beneficial to refer to experimental data, as “theoretical predictions may not fully account for the complexity of molecular interactions.” Therefore, always conduct empirical tests for precise solubility evaluations for this compound.

In summary, the solubility of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone nitrate is likely to be influenced by its polar characteristics and functional groups. Consequently, it may exhibit appreciable solubility in both polar and some non-polar solvents.

Interesting facts

Interesting Facts about 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone Nitrate

This compound stands out in the realm of chemical research due to its unique structural features and potential applications. Here are some intriguing aspects:

  • Pharmacological Potential: The presence of the imidazolium moiety in this compound suggests potential activities in medicinal chemistry, especially as a candidate for antibacterial or antifungal agents.
  • Chloro-Substituted Phenyl Ring: The incorporation of 2,4-dichlorophenyl groups highlights the compound's potential for interesting electronic properties and its utility in material science.
  • Robust Stability: Nitrate formulation contributes to stability under various conditions, which can impact its storage and application in different chemical contexts.
  • Versatility: This compound may serve as a scaffold for further chemical modifications, paving the way for the synthesis of more complex derivatives with enhanced properties.
  • Research Interest: The study of such compounds often involves exploring their interactions with biological molecules, providing insights that could lead to significant advancements in drug design.

In the words of a famous chemist, “Chemistry is not a mere art of combining substances but a quest to unlock the secrets of nature.” This compound epitomizes that quest, hinting at myriad possibilities waiting to be explored.

In conclusion, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone nitrate is not only a molecule of academic interest, but also a promising candidate for future research in various fields.

Synonyms
ACETOPHENONE, 2',4'-DICHLORO-2-(1-IMIDAZOLYL)-, NITRATE
RefChem:1075894
N-(2,4-Dichlorophenacyl)imidazole nitrate
EINECS 246-039-9
24155-29-1