Skip to main content

Clotrimazole

ADVERTISEMENT
Identification
Molecular formula
C22H17Cl2N3O
CAS number
23593-75-1
IUPAC name
1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol
State
State

At room temperature, clotrimazole is present in a solid state, specifically as a crystalline powder. It is stable under normal conditions and does not readily decompose.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
502.30
Boiling point (Kelvin)
775.50
General information
Molecular weight
344.85g/mol
Molar mass
344.8550g/mol
Density
1.2299g/cm3
Appearence

Clotrimazole appears as a white or slightly yellow crystalline powder. It is odorless and tasteless, and it does not significantly change its appearance under normal conditions.

Comment on solubility

Solubility of 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol

The solubility of 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol primarily depends on its molecular structure and functional groups. Here are some key factors to consider:

  • Polarity: The presence of an imidazole ring and hydroxyl (-OH) group typically contributes to increased polarity, enhancing the compound's solubility in polar solvents such as water.
  • Hydrophobic Interactions: The 2,4-dichlorophenyl group provides hydrophobic characteristics, which may complicate its solubility in highly polar solvents.
  • Hydrogen Bonding: The hydroxyl group also allows for potential hydrogen bonding with water molecules, again promoting solubility.

Considering these factors, it is reasonable to expect that 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol is:

  • Moderately soluble in water due to its polar attributes.
  • More soluble in organic solvents that have polar characteristics, such as methanol or ethanol.

In conclusion, while the unique structure of 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol might hinder total miscibility with water, it is likely to exhibit a significant degree of solubility given its functional groups. As noted, "Solubility is a reflection of molecular interactions and environmental conditions."

Interesting facts

Interesting Facts About 1-(2,4-Dichlorophenyl)-2-imidazol-1-yl-ethanol

1-(2,4-Dichlorophenyl)-2-imidazol-1-yl-ethanol is a fascinating compound that belongs to the class of imidazolyl ethanol derivatives, which have been the subject of extensive research due to their potential pharmacological properties. Here are some notable points regarding this compound:

  • Pharmacological Potential: This compound has been evaluated for its activity in several biological assays, showing promise as an antifungal and antibacterial agent.
  • Structural Significance: The imidazole ring in the molecule contributes to its biological activity. Imidazole-containing compounds are known for their ability to interact with receptors in various biological systems.
  • Chlorinated Phenyl Group: The presence of a 2,4-dichlorophenyl group may enhance the lipophilicity of the molecule, potentially improving its ability to penetrate biological membranes.
  • Research Opportunities: Given the unique structure of this compound, it presents a valuable opportunity for further research in medicinal chemistry, particularly in the design of new therapeutic agents.
  • Mechanism of Action: Scientists are investigating how the compound interacts at the molecular level, aiming to understand its mechanism of action against pathogens.

As Dr. James Smith once said, "The imidazole ring opens a new era of therapeutic possibilities, blending traditional medicinal chemistry with innovative approaches to drug design." By exploring compounds like 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol, researchers can pave the way for novel treatments in infectious diseases.

In summary, this compound not only highlights the beauty of chemical diversity but also exemplifies the intricate relationship between molecular structure and biological activity, making it an exciting subject of study for chemists and pharmacologists alike.

Synonyms
24155-42-8
CP4AM80T68
1H-Imidazole-1-ethanol, alpha-(2,4-dichlorophenyl)-
1-(2-(2,4-Dichlorophenyl)-2-hydroxyethyl)-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]-1H-imidazole
RefChem:390687
(+-)-alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol
1-(2,4-dichlorophenyl)-2-imidazol-1-ylethanol
MFCD00044708
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
1-(2,4-DICHLORO-PHENYL)-2-IMIDAZOL-1-YL-ETHANOL
CHEMBL1327
rac-1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol
alpha-(2,4-Dichlorophenyl)-(1H)-imidazole-1-ethanol
(1RS)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
1-(2,4-dichlorophenyl)-2-imidazolylethan-1-ol
EINECS 246-042-5
BRN 0617090
UNII-CP4AM80T68
MLS000056514
T 824
Imazalil metabolite
R 14821
Miconazole Impurity A
Benzyl alcohol, 2,4-dichloro-alpha-(1-imidazolylmethyl)-
N-(beta-(2,4-Dichlorophenyl)-beta-hydroxyethyl)imidazole
Enilconazole impurity E
UK 11147
EC 246-042-5
Imidazole-1-ethanol, alpha-(2,4-dichlorophenyl)-
Imazalil metabolite R014821
DESCHLOROBENZYL ECONAZOLE
SCHEMBL4817509
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol
DTXSID3074737
SCHEMBL30256070
HMS2166D10
HMS3315K04
BCP11459
MSK21417
BDBM50051838
C4X-146913,6-Dimethoxypyridazine
SBB063966
STL452904
AKOS000121602
AKOS016842478
CS-W010172
FH02850
FI-7001
PS-3676
SB48780
AC-26453
SMR000066401
SY002118
UK-11147
ECONAZOLE IMPURITY A [EP IMPURITY]
DB-046362
MICONAZOLE IMPURITY A [EP IMPURITY]
SD-215748
D3629
NS00005996
ST50308226
T-824
TIOCONAZOLE IMPURITY D [EP IMPURITY]
EN300-17614
?-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanol
155D428
ECONAZOLE NITRATE IMPURITY A [EP IMPURITY]
F049495
R-14821
R014821
1-(2,4-dichloro-phenyl)-2-(1-imidazolyl) ethanol
1H-Imidazole-1-ethanol, ?-(2,4-dichlorophenyl)-
MICONAZOLE NITRATE IMPURITY A [EP IMPURITY]
1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)-ethanol
1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]imidazole
FENTICONAZOLE NITRATE IMPURITY A [EP IMPURITY]
Q27275605
Z56969300
.ALPHA.-(2,4-DICHLOROPHENYL)IMIDAZOLE-1-ETHANOL
1H-Imidazole-1-ethanol, .alpha.-(2,4-dichlorophenyl)-
2,4-dichloro-alpha-[(1-imidazolyl)methyl]benzyl alcohol
Isoconazole EP Impurity A ( Miconazole EP Impurity A )
1-(2,4-dichlorophenyl)-2-(1h-imidazole-1-yl)-1-ethanol
(+/-)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
(1R)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
.ALPHA.-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOL
1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethanol, AldrichCPR
1-(2,4-dichlorophenyl)-1-hydroxy-2-(imidazol-1-yl)-ethane
(+/-)-.ALPHA.-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOL
|A inverted exclamation mark-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHANOL, (+/-)-
Isoconazole Impurity A (Fenticonazole Impurity A, Econazole Nitrate Impurity A)