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Clotrimazole

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Identification
Molecular formula
C22H17Cl2N3O
CAS number
23593-75-1
IUPAC name
1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone
State
State

At room temperature, clotrimazole is in a solid crystalline state. Due to its solid state, it must be dissolved in a suitable solvent or heated to create a liquid form, typically for applications like creams or solutions.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
257.00
Boiling point (Kelvin)
530.15
General information
Molecular weight
344.84g/mol
Molar mass
344.8350g/mol
Density
1.2455g/cm3
Appearence

Clotrimazole is typically a white to pale yellow crystalline powder. It is odorless and is not highly soluble in water, but dissolves in organic solvents. The crystalline nature gives it a slightly off-white tint, which is consistent with many imidazole derivatives.

Comment on solubility

Solubility of 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone

The solubility of the compound 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone, often referred to for its notable functional groups, can vary significantly based on its environment. Understanding its solubility is critical for applications in pharmaceuticals and chemical synthesis.

Key factors influencing the solubility include:

  • Polarity: The presence of electronegative atoms in the dichlorophenyl and imidazole rings contributes to the overall polarity of the molecule.
  • Solvent Interaction: It tends to exhibit better solubility in polar solvents, such as ethanol or methanol, compared to non-polar solvents due to potential hydrogen bonding and dipole interactions.
  • Temperature: Increasing the temperature can enhance solubility, which is a common observation for many organic compounds.

As a rule of thumb, "like dissolves like," meaning polar compounds tend to dissolve in polar solvents while non-polar compounds favor non-polar environments. Thus, understanding the balance of polar and non-polar sections of 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone aids in predicting its solubility behavior.

In summary, while definitive solubility data may vary, this compound is expected to show limited solubility in non-polar solvents and enhanced solubility in polar solvents, providing versatility in its application within chemical processes.

Interesting facts

Exploring 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone

1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone, often abbreviated in chemistry discussions for convenience, is a fascinating compound known for its diverse applications in pharmaceuticals and agriculture. Here are some intriguing aspects of this compound:

  • Pharmaceutical Character: This compound belongs to a class of molecules that exhibit significant biological activity, making it a potential candidate for drug development. Its structure suggests it may interact with specific biological targets, which is essential for medicinal chemistry.
  • Agricultural Uses: Due to its chemical properties, 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone may find roles in agrochemicals, serving as a pesticide or herbicide to protect crops from various pests.
  • Chemical Versatility: The presence of both dichlorobenzenes and imidazole rings contributes to its versatility. This makes it a valuable intermediate in organic synthesis, paving the way for more complex molecules.
  • Structure-Activity Relationship (SAR): Understanding the relationships between its molecular structure and biological activity can provide insights into optimizing its efficacy and reducing potential side effects.

This compound is part of ongoing research, where scientists aim to uncover new biological activities and applications. As with many chemical entities, the exploration of its mechanisms and interactions with biological systems is a promising avenue for future study. As stated by renowned chemists, "the secrets of nature are revealed through the languages of chemistry." 

In summary, 1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone stands at the intersection of pharmacology and chemistry, representing the potential for innovative advancements in both fields.

Synonyms
46503-52-0
1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one
EINECS 256-273-3
DTXSID10196862
RefChem:420416
DTXCID50119353
256-273-3
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone
1-(2,4-dichlorophenyl)-2-imidazol-1-ylethanone
1-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanone
MFCD00617550
ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-
1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanone
1-(2,4-Dichlorobenzoylmethyl)imidazole
imazalil TP1
Miconazole Impurity 29
Cambridge id 5308482
CHEMBL350843
IFLab1_001176
SCHEMBL2454118
2,4-dichlorophenacyl-1H-imidazol
HMS1415F10
HMS5169G07
N-(2,4-dichlorophenacyl)imidazole
N-(2,4-dichlorophenacyl)-imidazole
1-(2,4-dichlorophenacyl) imidazole
AKOS005255825
AC-8782
IDI1_009043
DB-001162
NS00031611
ST51001072
1-(2,4-dichlorophenyl)2-imidazol-1-ylethanol
A51084
AB00079877-01
503D520
SR-01000394043
SR-01000394043-1
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone
2'-(1H-IMIDAZL-1-YL)-2,4-DICHLOROACETOPHENONE
InChI=1/C11H8Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15/h1-5,7H,6H