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Trimethoxyamphetamine

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Identification
Molecular formula
C12H19NO3
CAS number
2275-23-2
IUPAC name
1-(2,4,6-trimethoxyphenyl)propan-2-amine
State
State

At room temperature, trimethoxyamphetamine is a solid.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
317.70
Boiling point (Kelvin)
590.85
General information
Molecular weight
197.26g/mol
Molar mass
197.2550g/mol
Density
1.0630g/cm3
Appearence

Trimethoxyamphetamine, often abbreviated as TMA, typically appears as a crystalline powder or solid. Its color can range from white to off-white or pale beige, depending on the purity and specific synthesis processes used.

Comment on solubility

Solubility of 1-(2,4,6-trimethoxyphenyl)propan-2-amine

When examining the solubility of 1-(2,4,6-trimethoxyphenyl)propan-2-amine, it is important to consider its chemical structure and the presence of functional groups. This compound contains a propan-2-amine backbone and a heavily substituted aromatic ring, which plays a significant role in its interactions with solvents.

Here are some key points regarding its solubility:

  • Aromatic Character: The presence of the trimethoxy groups on the aromatic ring suggests that the compound may exhibit varying degrees of solubility in organic solvents, particularly polar protic solvents. The strong electron-donating properties of the methoxy groups can enhance its solubility in certain environments.
  • Amine Functional Group: The amine group may confer some degree of solubility in water, especially under the right conditions. However, the overall structure may limit its aqueous solubility.
  • Effect of Substituents: The bulkiness and electron-donating nature of the trimethoxy substituents could impede solubility in highly polar solvents and may lead to reduced solubility in water.

In conclusion, while it is challenging to predict the solubility of 1-(2,4,6-trimethoxyphenyl)propan-2-amine without experimental data, one can hypothesize that:

  • It is more likely to be soluble in organic solvents.
  • Its solubility in water may be limited due to the complex interplay of its aromatic and amine functional groups.
  • Further studies are recommended to determine precise solubility characteristics across various solvents.
Interesting facts

Exploring 1-(2,4,6-trimethoxyphenyl)propan-2-amine

1-(2,4,6-trimethoxyphenyl)propan-2-amine, often referred to as a derivative of phenethylamine, is an intriguing compound with various notable attributes:

  • Structural Uniqueness: This compound features a distinctive structure that includes a propan-2-amine backbone bound to a highly substituted phenyl ring. The presence of three methoxy groups at positions 2, 4, and 6 contributes to its complex chemical behavior.
  • Potential Biological Activity: Compounds like 1-(2,4,6-trimethoxyphenyl)propan-2-amine can exhibit biological activities, making them of interest in medicinal chemistry. Research into derivatives of phenethylamine has linked them to various effects, including stimulatory or psychoactive properties.
  • Sympathomimetic Effects: Similar compounds have been studied for their sympathomimetic effects, which could lead to applications in pharmacology. These properties make them valuable in developing therapeutic agents aimed at treating attention deficits and mood disorders.
  • Natural Occurrence: The methoxy groups present in this compound are reminiscent of compounds found in natural sources, particularly in plant alkaloids, hinting at their ecological roles and potential medicinal properties derived from nature.

In summary, the exploration of 1-(2,4,6-trimethoxyphenyl)propan-2-amine not only reveals its complex chemical structure but also sheds light on its potential implications in medicinal chemistry. As chemistry enthusiasts and scientists, we are continually intrigued by how alterations in molecular structure can lead to significant variations in biological function.

Synonyms
2,4,6-TRIMETHOXYAMPHETAMINE
15402-79-6
2X84DCO6GA
TMA-6
2,4,6-Trimethoxyamphetamine, DL-
benzeneethanamine, 2,4,6-trimethoxy-alpha-methyl-
1-(2,4,6-trimethoxyphenyl)propan-2-amine
(+/-)-2,4,6-Trimethoxyamphetamine
J273.469I
UNII-2X84DCO6GA
Phenethylamine, 2,4,6-trimethoxy-alpha-methyl-
CHEMBL34108
DTXSID40874363
2,4,6-TRIMETHOXYAMPHETAMIN
RefChem:1049020
Phenethylamine, 2,4,6-trimethoxy-.alpha.-methyl-
SCHEMBL394380
Benzeneethanamine, 2,4,6-trimethoxy-.alpha.-methyl-
Benzeneethanamine, 2,4,6-trimethoxy-a-methyl- (9CI)
Benzenethanamine, 2,4,6-trimethoxy-alpha-methyl-, (+-)-
DTXCID30970909
DDGNOUVDFKXADP-UHFFFAOYSA-N
(+-)-2,4,6-Trimethoxyamphetamine
(d,l)-2,4,6-Trimethoxyamphetamine
2,4,6-Trimethoxyphenylisopropylamine
BDBM50164328
AKOS009377303
DL-2,4,6-TRIMETHOXYAMPHETAMINE
22199-16-2
PD047613
DB-345129
NS00017425
1-Methyl-2-(2,4,6-trimethoxy-phenyl)-ethylamine
1-Methyl-2-(2,4,6-trimethoxyphenyl)ethylamine #
Q27255748
(+/-)1-Methyl-2-(2,4,6-trimethoxy-phenyl)-ethylamine
Phenethylamine, 2,4,6-trimethoxy-a-methyl- (6CI,8CI)
Benzeneethanamine,2,4,6-trimethoxy-.alpha.-methyl-(.+/-.)-
Benzenethanamine, 2,4,6-trimethoxy-.alpha.-methyl-(.+/-.)-