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Indometacin

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Identification
Molecular formula
C19H16Cl2NO2
CAS number
53-86-1
IUPAC name
1-(2,6-dichlorophenyl)indolin-2-one
State
State
At room temperature, Indometacin is a solid. It exists in a stable crystalline form and should be kept in a cool, dry place to retain its stability and effectiveness.
Melting point (Celsius)
160.50
Melting point (Kelvin)
433.65
Boiling point (Celsius)
558.80
Boiling point (Kelvin)
831.95
General information
Molecular weight
357.24g/mol
Molar mass
357.7970g/mol
Density
1.2860g/cm3
Appearence
Indometacin typically appears as a white to yellowish crystalline powder. It might also exhibit a slight off-white color due to varying purity or external factors. The compound should be handled with care to maintain its powder integrity, and it should be stored away from light and moisture to prevent degradation.
Comment on solubility

Solubility of 1-(2,6-dichlorophenyl)indolin-2-one

1-(2,6-dichlorophenyl)indolin-2-one, a compound with a complex structure, presents intriguing solubility characteristics that are essential for its application in various fields. Here's a closer look at its solubility features:

  • Solvent Interaction: The solubility of this compound tends to vary significantly depending on the solvent used. It is generally soluble in organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and ethyl acetate. However, it exhibits limited solubility in polar solvents like water.
  • pH Dependence: The solubility characteristics may also demonstrate dependence on the pH of the solution. Changes in pH can affect the ionization state and, consequently, the solubility of the compound.
  • Temperature Effects: Just like many organic compounds, 1-(2,6-dichlorophenyl)indolin-2-one's solubility could improve with an increase in temperature, making it vital to consider thermal conditions when preparing solutions.

As a general rule, it's critical to perform solubility tests in different solvents to fully determine the most suitable conditions for this compound. Understanding its solubility will assist in its efficient use in research and potential applications. Exploring these aspects can provide valuable insights into its chemistry and behavior in various environments.

Interesting facts

Interesting Facts about 1-(2,6-Dichlorophenyl)indolin-2-one

1-(2,6-Dichlorophenyl)indolin-2-one is a fascinating compound with a variety of notable attributes that make it important in the realm of chemistry and potential applications in pharmaceuticals:

  • Diverse Biological Activity: This compound exhibits a range of biological activities, making it a subject of interest in medicinal chemistry. Its structural integrity allows it to interact with numerous biological targets, revealing potential therapeutic roles.
  • Structural Complexity: The presence of both the indoline and dichlorophenyl moieties contributes to its unique properties. These structural features can influence the compound’s behavior in biological systems, enhancing its potency.
  • Research Applications: Scientists are particularly focused on the compound for its potential use as an anticancer agent. Research has suggested that it can hinder cancer cell proliferation, showcasing promising results in various in vitro studies.
  • Agonist Potential: Certain studies suggest that compounds like 1-(2,6-Dichlorophenyl)indolin-2-one can function as agonists for specific receptors, inspiring ongoing research into their role in receptor-mediated signaling pathways.
  • Leading to Derivatives: The ability to modify the structure of 1-(2,6-Dichlorophenyl)indolin-2-one paves the way for the development of analogs with enhanced properties, which can be tailored for specific applications in drug discovery.
  • Interdisciplinary Relevance: Beyond its chemical and biological significance, this compound serves as a bridge between fields such as organic chemistry, biochemistry, and pharmacology, illustrating the interdisciplinary nature of contemporary scientific research.

In conclusion, 1-(2,6-Dichlorophenyl)indolin-2-one stands as a remarkable compound with promising implications within various scientific disciplines. As research advances, this compound could yield even more groundbreaking discoveries that may alter the landscape of drug development and therapeutic applications. Its multifaceted nature hints at a broader potential that is yet to be fully realized.

Synonyms
1-(2,6-Dichlorophenyl)-2-indolinone
15362-40-0
1-(2,6-Dichlorophenyl)indolin-2-one
1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one
DTXSID6046979
CL5Y02756K
NSC-621845
DTXCID4026979
1-(DCP)I
239-399-3
Diclofenac Amide
1-(2,6-Dichlorophenyl)oxindole
1-(2,6-dichlorophenyl)-3H-indol-2-one
MFCD00451393
2H-Indol-2-one, 1-(2,6-dichlorophenyl)-1,3-dihydro-
N-(2,6-Dichlorophenyl)-2-indolinone
1,3-Dihydro-1-(2,6-dichlorophenyl)-2H-indol-2-one
F1236-0045
2H-INDOL-2-ONE, 1,3-DIHYDRO-1-(2,6-DICHLOROPHENYL)-
Diclofenac EP Impurity A
EINECS 239-399-3
ChemDiv3_002423
BRN 1538309
UNII-CL5Y02756K
Diclofenac artifact
Diclofenac impurity A
N-(2,6-dichlorophenyl)indolin-2-one
1-(2,6-Dichlorophenyl)-2-oxoindoline
Aceclofenac Impurity I
MLS000527383
1-(2,6-Dichloro-phenyl)-1,3-dihydro-indol-2-one
1-(2,6-dichlorophenyl)-2,3-dihydro-1H-indol-2-one
CHEMBL487716
orb1310422
SCHEMBL2982634
SCHEMBL29651988
HMS1479O03
HMS2295G12
SMSSF-0064477
BCP24489
Tox21_301756
AC-327
NSC621845
STK709153
AKOS000530778
CCG-272701
SB64040
UPCMLD0ENAT5559022:001
NCGC00245217-01
NCGC00256032-01
AS-12117
NCI60_006351
SMR000117857
SY030556
CAS-15362-40-0
DB-043195
ST4053425
ACECLOFENAC IMPURITY I [EP IMPURITY]
CS-0144094
D4260
NS00004994
2-INDOLINONE, 1-(2,6-DICHLOROPHENYL)-
EN300-7364240
1-(2,6-dichlorophenyl)-2-indolinone, AldrichCPR
DICLOFENAC SODIUM IMPURITY A [EP IMPURITY]
SR-01000457522
SR-01000457522-1
BRD-K18569286-001-01-2
DICLOFENAC POTASSIUM IMPURITY A [EP IMPURITY]
Q27275517
Z57241954
1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one #
N-(2,6-Dichlorophenyl)-2-indolinone, analytical standard
Aceclofenac impurity I, European Pharmacopoeia (EP) Reference Standard
Diclofenac impurity A, European Pharmacopoeia (EP) Reference Standard
N-(2,6-Dichlorophenyl)-2-indolinone, British Pharmacopoeia (BP) Reference Standard
Voltindole (Aceclofenac EP Impurity I, Diclofenac EP Impurity A, Diclofenac Amide)
1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one;1-(2,6-Dichlorophenyl)oxindole;N-(2,6-dichlorophenyl)-2-indolinone