Interesting facts
Interesting Facts about 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-dione
This compound represents a fascinating intersection of organic chemistry and pharmaceutical applications, making it a notable subject of study for many researchers. Here are some intriguing aspects:
- Structure Complexity: The compound features a unique structural arrangement, including both a pyrimidine and a tetrahydrofuran ring, contributing to its biological activity.
- Fluorine Substitution: The presence of fluorine in the pyrimidine ring often enhances the compound's stability and lipophilicity, which can improve its absorption and efficacy as a drug.
- Hydroxyl Groups: The multiple hydroxyl (-OH) groups in the tetrahydrofuran moiety play a critical role in determining the compound's solubility and reactivity, potentially facilitating hydrogen bonding with biological targets.
- Potential Applications: Given its structure, this compound could serve as a lead compound in the development of antiviral or anticancer agents. The ability of pyrimidine derivatives to interfere with nucleic acid synthesis positions them as valuable in medical research.
- Chirality Matters: The chirality of the tetrahydrofuran component suggests that different enantiomers could exhibit distinct biological behaviors, making stereochemical purity vital in pharmaceutical development.
As noted in a scientific paper, "Understanding the synthetic pathways and biological interactions of such complex compounds can unlock new therapeutic strategies." This underscores the importance of this compound in ongoing research and its potential to contribute to medical advancements in the near future.
Overall, studying this compound opens a window into the intricate world of organic chemistry and its significant impact on drug discovery.
Synonyms
5-Fluorouridine
316-46-1
5-Fur
Uridine, 5-fluoro-
fluorouridine
5-Fluoro Uridine
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
5-Fluoro-uridine
5-Fluorouracil 1beta-D-ribofuranoside
EINECS 206-260-3
MFCD00036832
NSC 146604
BRN 0033662
FUrd
CHEBI:40154
UNII-4K0M952561
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
5-fluoro-1-(beta-d-ribofuranosyl)uracil
CHEMBL54918
4K0M952561
DTXSID4040397
4-24-00-01231 (Beilstein Handbook Reference)
NSC-146604
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
5-FLUOROURACIL-.BETA.-D-RIBOFURANOSIDE
5-FLUOROURACIL-1.BETA.-D-RIBOFURANOSIDE
Fur
C9H11FN2O6
1-(b-D-Xylofuranosyl)-5-fluorouracil
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-fluoropyrimidine-2,4-dione
5UD
5-fluoro-d-uridine
beta-D-5FdU
5-fluorouracil-1beta-d-ribofuranoside
4pb2
cid_1821
SCHEMBL53091
BIDD:GT0496
GTPL4614
DTXCID2020397
18814-21-6
AFU
BDBM50132299
AKOS015852922
AKOS015918304
5-Fluorouracil 1-.beta.-D-arabinosyl
DB01629
NF04076
5-Fluorouridine, >=99.0% (HPLC)
NCGC00142485-01
NCGC00142485-02
NCGC00142485-03
1-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,3-dihy dropyrimidine-2,4-dione
5-Fluoro-1-.beta.-D-ribofuranosyluracil
AS-13467
BP-58617
PD008907
5-FLUOROURACIL-BETA-D-RIBOFURANOSIDE
DB-005381
HY-107856
CS-0030739
NS00015326
EN300-221740
F58596
Q27073979
Z1741958657
1-(b-D-Ribofuranosyl)-5-fluorouracil;5-Fluoro-D-uridine;FUrd
1-.beta.-D-Arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione, 1-.beta.-D-arabinofuranosyl-5-fluoro-
5-Fluorouridine, proapoptotic anitproliferative plant growth regulator
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione
1-((2R,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione
1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione(5F-dUrd)
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-dione
206-260-3
Solubility of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-dione
The solubility of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-dione is influenced by multiple factors, considering the complexity of its structure. This compound contains functional groups that can significantly affect its interaction with solvents:
It is essential to note that solubility might be relatively high in water due to hydrophilic interactions caused by the hydroxyl groups, yet the fluorine can potentially introduce some hydrophobic characteristics that counteract total solubility. In summary, it can be expressed as:
Experimental data would ultimately be required for precise solubility values, but the theoretical understanding suggests this compound might showcase variability in solubility across different solvents, illustrating the fascinating nature of organic compounds.