Skip to main content

Asenapine

ADVERTISEMENT
Identification
Molecular formula
C21H20ClN3O
CAS number
65547-13-5
IUPAC name
1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
State
State

At room temperature, asenapine exists in a solid state in the form of a powder. It is stable under normal conditions but should be stored away from light and moisture to avoid degradation.

Melting point (Celsius)
189.00
Melting point (Kelvin)
462.15
Boiling point (Celsius)
289.30
Boiling point (Kelvin)
562.45
General information
Molecular weight
285.77g/mol
Molar mass
285.7700g/mol
Density
1.2670g/cm3
Appearence

Asenapine typically appears as a white to off-white powder. It is not significantly hydrophobic, making it less lipophilic compared to some other antipsychotic agents.

Comment on solubility

Solubility of 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one

The solubility of the compound C21H20ClN3O is influenced by several factors due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of a chlorine atom and various nitrogen functionalities suggests a moderate polarity, which can impact its solubility in different solvents.
  • Solvent Interaction: Typically, non-polar compounds or those with extensive hydrophobic regions are more soluble in organic solvents such as ethanol or DMSO, while polar solvents like water might show limited solubility.
  • Hydrogen Bonding: Functional groups capable of hydrogen bonding can enhance solubility in polar solvents. If the compound can form such interactions, it may have better solubility in water.
  • Crystal Lattice Energy: The solid-state arrangement of the compound can also affect its solubility. A strong crystal lattice can hinder dissolution, whereas weaker interactions may facilitate it.
  • Temperature Dependence: Solubility often increases with temperature for many compounds, suggesting that heating the solvent may help in achieving greater solubility.

In conclusion, the solubility of C21H20ClN3O is likely to be variable, depending largely on the solvent system used and the specific conditions such as temperature and pH. Understanding these parameters is crucial for effective practical applications of this compound.

Interesting facts

Interesting Facts about 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one

This complex chemical compound, known for its significant structural uniqueness, belongs to a class of compounds that have garnered attention in medicinal chemistry. Here are some intriguing details:

  • Structural Complexity: The compound features a spiro structure, which is a hallmark of numerous biologically active molecules, providing unique steric and electronic properties that can influence its interaction with biological targets.
  • Therapeutic Potential: Compounds closely related to this class often exhibit interesting pharmacological properties, making them potential candidates for the treatment of various neurological disorders. Research indicates that modified analogs could be effective in context to drug development.
  • Chlorination Impact: The presence of the chlorine atom contributes both to the molecule's reactivity and its ability to modulate biological pathways. Chlorinated compounds can often show increased lipophilicity, aiding in the absorption and distribution within biological systems.
  • Multi-functional Groups: It features an array of functional groups, such as the imidazopyridine and piperidine moieties, which can be pivotal in mediating drug-receptor interactions. These groups often enhance biological activity through diverse binding mechanisms.
  • Research Interest: As an active area of research, scientists are keen on exploring how subtle changes in the chemical structure can lead to variations in bioactivity, safety profiles, and side effects.

In summary, this compound represents a fascinating intersection of synthetic organic chemistry and pharmacology, with the potential for profound implications in drug discovery. Those engaged in the study of such compounds are often at the forefront of efforts to understand their mechanistic roles in biological systems, making their research critical to advancing therapeutic options.

Synonyms
Mosapramine
89419-40-9
Mosapramine [INN]
Clospipramine
Mosapramina
04UZQ7O9SJ
Mosapramine (INN)
DTXSID0048846
MOSAPRAMINE [MI]
Mosapramine (hydrochloride)
MOSAPRAMINE [MART.]
Clospipramine (hydrochloride)
MOSAPRAMINE [WHO-DD]
DTXCID7028772
CHEBI:135775
1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
1'-[3-(3-chloro-10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2h-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
NCGC00183853-01
MOSAPRAMINE (MART.)
(+/-)-1'-(3-(3-CHLORO-10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-5-YL)PROPYL)HEXAHYDROSPIRO(IMIDAZO(1,2-A)PYRIDINE-3(2H),4'-PIPERIDIN)-2-ONE
1'-(3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
UNII-04UZQ7O9SJ
mosapraminum
rac-mosapramine
racemic mosapramine
(RS)-mosapramine
1'-(3-(14-chloro-2-azatricyclo(9.4.0.0^(3,8))pentadeca-1(11),3,5,7,12,14-hexaen-2-yl)propyl)-hexahydro-1H-spiro(imidazo(1,2-a)pyridine-3,4'-piperidin)-2-one
1'-(3-{14-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}propyl)-hexahydro-1H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
rac-1'-(3-(3-chloro-10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)propyl)hexahydro-2H-spiro(imidazo(1,2-a)pyridine-3,4'-piperidin)-2-one
rac-1'-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
(+-)-mosapramine
3-chloro-5-(3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo(1,2-a)pyridine-3-spiro-4'-piperidino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
SCHEMBL147139
CHEMBL2106650
N05AX10
CHEBI:166972
Tox21_113329
BDBM50530438
AKOS016014037
DB13676
DA-75682
CAS-89419-40-9
HY-106584
CS-0026106
NS00124555
D08235
L004956
Q6144116
(+-)-1'-(3-(3-Chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)hexahydrospiro(imidazo(1,2-a)pyridine-3(2H),4'-piperidin)-2-one
(- )-1'-(3-(3-Chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)hexahydrospiro(imidazo(1,2-a)pyridine-3(2H),4'-piperidin)-2-one.
Mosapramine; Spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-; Spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexah