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Lobeline

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Identification
Molecular formula
C22H27ClN2O2
CAS number
90-69-7
IUPAC name
1-[3-(2-chlorobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide
State
State

At room temperature, lobeline exists as a solid. It is typically processed for use in various forms, including powders and capsules in pharmaceutical applications.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
446.00
Boiling point (Kelvin)
719.15
General information
Molecular weight
264.39g/mol
Molar mass
264.3930g/mol
Density
1.2150g/cm3
Appearence

Lobeline appears as a crystalline solid that can range in color from white to off-white. It is often found in powdered form and is known for its characteristic crystalline structure.

Comment on solubility

Solubility Characteristics

The compound 1-[3-(2-chlorobenzob[1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide exhibits unique solubility properties due to its complex structure. Understanding its solubility profile is crucial for its applications in pharmaceutical formulations. Here are the key aspects:

  • Polar vs Non-Polar: The presence of multiple functional groups, such as a carboxamide, influences the solubility in polar solvents like water, while hydrophobic aromatic components may hinder it.
  • Influence of Substituents: The 2-chlorobenzob[1]benzazepin moiety can affect solubility, as halogen substitutions often lead to diverse solubility behaviors.
  • pH Dependency: Being a carboxamide, its solubility may be pH-dependent, impacting its ionization state and, consequently, its interaction with solvents.

As a result, the solubility of this compound can range from limited to moderate in various solvents. It might be poorly soluble in cold water, but may dissolve better in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).

In summary, the solubility of 1-[3-(2-chlorobenzob[1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide is intricately linked to its structural characteristics, and careful consideration must be taken when formulating this compound into drug delivery systems.

Interesting facts

Interesting Facts about 1-[3-(2-chlorobenzo·[1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide

The compound 1-[3-(2-chlorobenzo·[1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide is a fascinating example of how intricate the world of organic chemistry is. This compound belongs to a class known as carboxamides, which are known for their diverse biological activities and are often utilized in pharmaceutical applications.

Here are some noteworthy aspects of this compound:

  • Complex Structure: The structure incorporates both piperidine and benzazepine rings, highlighting the evolutionary path of chemical design towards creating molecules with specific properties.
  • Biological Significance: Molecules like this have been studied for their potential roles in treating various neurological conditions, showcasing the bridge between chemical synthesis and medicinal chemistry.
  • Synthetic Challenges: The multi-functionalization of the piperidine moiety presents unique synthetic challenges, as chemists have to carefully navigate reactivity patterns to achieve the desired final product.

This compound exemplifies the continuous quest in chemical research to discover and design new therapeutic agents. As noted by chemist Linus Pauling, “The best way to have a good idea is to have a lot of ideas.” In that spirit, compounds like this one drive innovation through their complex designs and potential applications.

Furthermore, the presence of the chlorine substituent can significantly influence the compound’s biological activities, enhancing its interaction with specific receptors in the body. The intricate dance of atoms in such compounds not only showcases the creativity involved in their formation but also underlines the importance of ongoing research in this field. Who knows what exciting discoveries await from compounds like this?