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Thioridazine hydrochloride

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Identification
Molecular formula
C21H26N2S·2HCl
CAS number
130-61-0
IUPAC name
1-[3-(2-methylphenothiazin-10-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide;dihydrochloride
State
State

At room temperature, Thioridazine hydrochloride is usually found as a solid. It is frequently used in its solid form for pharmaceutical formulations.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.00
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.00
General information
Molecular weight
407.51g/mol
Molar mass
407.5080g/mol
Density
1.3120g/cm3
Appearence

Thioridazine hydrochloride appears as a pale yellow to yellow crystalline powder. It is typically used in a hydrated form and can absorb moisture from the air.

Comment on solubility

Solubility of 1-[3-(2-methylphenothiazin-10-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide; dihydrochloride

The solubility of 1-[3-(2-methylphenothiazin-10-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide; dihydrochloride is influenced by several factors, particularly due to its complex molecular structure. This compound is ionic in nature due to the presence of the dihydrochloride salt form, which affects its solubility profile. Generally, ionic compounds tend to have high solubility in polar solvents, such as water. Here are some key considerations:

  • Solvent Interaction: The dihydrochloride form suggests good solubility in aqueous solutions, as the chloride ions can stabilize the compound in water.
  • Temperature Dependence: Like many compounds, solubility might increase with temperature, making it more dissolvable at elevated temperatures.
  • pH Effects: The solubility can also be affected by the pH of the solution, as the ionization of the compound may lead to variations in solubility.
  • Organic Solvents: While it is expected to be highly soluble in water, its solubility in organic solvents such as ethanol or methanol may vary and is worth investigating.

In summary, the solubility of this compound is predominantly influenced by its ionic nature, making it suitable for dissolution in polar solvents, particularly water. According to the principle of solubility, "like dissolves like," therefore its ionic character aids in solubility in polar environments. Further studies would be required to quantify its solubility in various solvents comprehensively.

Interesting facts

Exploring 1-[3-(2-methylphenothiazin-10-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide; dihydrochloride

This intriguing compound belongs to a fascinating class of pharmaceuticals known as phenothiazines. These have made substantial contributions to medicinal chemistry, particularly in the treatment of various psychiatric disorders. Here are some compelling facts about this compound:

  • Psychoactive Properties: Phenothiazines, including this compound, are commonly utilized as antipsychotic medications, providing relief in conditions such as schizophrenia and bipolar disorder.
  • Complex Structure: The structural intricacies of this compound showcase a multi-ring system that enhances its potency and versatility within biological systems.
  • Mechanism of Action: These compounds primarily function by antagonizing dopamine D2 receptors in the brain, which plays a crucial role in modulating mood and perception.
  • Development History: The development of phenothiazine derivatives has a long history, dating back to the mid-20th century, where they revolutionized psychiatric treatments, marking the transition towards modern psychopharmacology.
  • Research Potential: Beyond their traditional uses, ongoing studies are investigating the potential of phenothiazines in treating other conditions such as neurodegenerative diseases, which highlights their broad therapeutic scope.

Moreover, the presence of both piperidine and carboxamide functional groups in this compound adds another layer of complexity, enhancing its ability to interact with multiple biological targets. As researchers continue to unravel the potential applications of compounds like this, it becomes evident that their intricate designs are key to unlocking innovative therapeutic pathways.

Overall, the study of 1-[3-(2-methylphenothiazin-10-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide; dihydrochloride not only reveals the depths of chemical ingenuity but also dovetails with the rich narrative of medicinal innovation.

Synonyms
13805-48-6
Isonipecotamide, 1-(3-(2-methylphenothiazin-10-yl)propyl)-4-piperidino-, hydrochloride, hydrate (1:2:1)
DTXSID20160458
DTXCID0082949