Skip to main content

Mesoridazine

ADVERTISEMENT
Identification
Molecular formula
C21H26N2O3S2
CAS number
5588-33-0
IUPAC name
1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide
State
State

At room temperature, mesoridazine is a solid.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.00
Boiling point (Celsius)
523.50
Boiling point (Kelvin)
796.50
General information
Molecular weight
456.62g/mol
Molar mass
456.6180g/mol
Density
1.3390g/cm3
Appearence

Mesoridazine typically appears as a yellow to tan crystalline powder. It is usually handled in its salt form for medical applications, specifically the besylate or succinate salt, which influences its appearance in formulations.

Comment on solubility

Solubility of 1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide

The solubility of the compound 1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide is influenced by its complex molecular structure. Generally, solubility can be affected by several key factors:

  • Polarity: The presence of a sulfonyl group enhances the polar character of the compound, potentially increasing its solubility in polar solvents.
  • Hydrogen Bonding: The amide functionality can engage in hydrogen bonding, which may improve solubility in protic solvents such as water.
  • Molecular Size: The larger molecular size could hinder effective interaction with solvent molecules, leading to lower solubility in non-polar solvents.

In practice, the solubility is typically examined at specific temperatures and concentrations. It’s essential to categorize this compound's solubility into:

  1. Soluble: Easily dissolves in the solvent.
  2. Partially Soluble: Dissolves to a limited extent.
  3. Insoluble: Does not dissolve appreciably.

To fully understand and predict the solubility behavior of C19H24N2O2S, it is crucial to conduct experimental assessments in various solvents. This approach would yield valuable insights into its practical applications in pharmaceuticals and other industries.

Interesting facts

Interesting Facts about 1-[3-(2-Methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide

This unique compound is a fascinating example of the intersection between medicinal chemistry and pharmacology. With its intricate structure, it holds significant promise for various therapeutic applications. Here are some compelling points to note:

  • Pharmacological Relevance: This compound is often explored for its potential role in treating psychiatric disorders. Compounds in the phenothiazine class are known for their antipsychotic properties.
  • Methylsulfonyl Group: The presence of the methylsulfonyl group enhances the compound's solubility and stability, which is crucial for drug efficacy in biological systems.
  • Piperidine Ring: The piperidine moiety adds to the bioactivity profile of the compound, providing a versatile scaffold that can facilitate interactions with various biological targets.
  • Structure-Activity Relationship (SAR): Researchers continuously study how modifications to the phenothiazine backbone influence the compound's pharmacological effect, aiming to optimize its therapeutic properties.
  • Synthesis Challenges: The synthesis of this compound can involve various complex reaction pathways, making it a subject of interest for synthetic chemists looking to innovate safer and more efficient production methods.

Overall, 1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide is not just a chemical entity but a key player in the ongoing quest for effective treatments in the fields of psychiatry and neurology. As the saying goes, "In chemistry, as in life, the whole is always more than the sum of its parts."

Synonyms
Metopimazine
14008-44-7
Metopimazina
EXP 999
Metopimazinum
EXP-999
238S75V9AV
1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide
DTXSID80161224
1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)isonipecotamide
1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide
1-(3-(2-methylsulfonylphenothiazin-10-yl)propyl)piperidine-4-carboxamide
DTXCID4083715
A04AD05
1-(3-(2-methylsulfonylphenothiazin-10-yl) propyl)isonipecotinamide
1-(3-(2-methanesulfonyl-10H-phenothiazin-10-yl)propyl)piperidine-4-carboxamide
237-818-4
Vogalene
4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-
1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
4-Piperidinecarboxamide, 1-(3-(2-(methylsulfonyl)-10H-phenothiazin-10-yl)propyl)-
RP-9965
Nortrip
1-(3-(2-(Methylsulfonyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinecarboxamide
Metopimazinum [INN-Latin]
Metopimazina [INN-Spanish]
RP 9965
EINECS 237-818-4
BRN 4278585
UNII-238S75V9AV
Metopimazine [USAN:INN:BAN]
2-Methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine
METOPIMAZINE [MI]
10-(3-(4-Carbamoylpiperidine)propyl)-2-(methanesulfonyl)phenothiazine
Phenothiazine, 10-(3-(4'-carbamoylpiperidino)propyl)-2-methylsulfonyl-
Metopimazine (USAN/INN)
METOPIMAZINE [INN]
1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)-4-piperidinecarboxamide
4-Piperidinecarboxamide, 1-(3-(2-(methanesulfonyl)phenothiazin-10-yl)propyl)-
METOPIMAZINE [USAN]
SCHEMBL49905
METOPIMAZINE [MART.]
METOPIMAZINE [WHO-DD]
CHEMBL398615
orb1703092
SCHEMBL29462317
SCHEMBL30038347
BDBM82383
GTPL11140
CHEBI:135726
BDBM179867
CAS_26388
NG-101
NSC_26388
AKOS005065914
ISONIPECOTAMIDE, 1-(3-(2-(METHYLSULFONYL)PHENOTHIAZIN-10-YL)PROPYL)-
BCP9000921
DB13591
US9132134, Metopimazine (NG101)
DA-55438
HY-116578
CS-0065952
NS00009519
D05010
Q194682
1-(3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl)-4-piperidinecarboxamide #