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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
1-[3-[3-(4-chlorophenyl)allyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]propan-1-one
State
State

At room temperature, loperamide is a solid. It is typically found in a powdered form for pharmaceutical formulations.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
388.58
Boiling point (Kelvin)
661.73
General information
Molecular weight
477.03g/mol
Molar mass
477.0330g/mol
Density
1.2360g/cm3
Appearence

Loperamide is a white to slightly off-white powder. It is odorless and has a bitter taste. In its pure form, it may appear as a crystalline solid.

Comment on solubility

Solubility Properties of 1-[3-[3-(4-chlorophenyl)allyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]propan-1-one

The solubility of 1-[3-[3-(4-chlorophenyl)allyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]propan-1-one is an intriguing aspect that significantly influences its applications and behavior in various environments. This compound, characterized by its complex structure, exhibits the following solubility characteristics:

  • Moderate Solubility: Generally, compounds with similar structures tend to have moderate solubility in polar solvents.
  • Aromatic Influence: The presence of the 4-chlorophenyl group can enhance solubility in organic solvents due to hydrophobic interactions.
  • Diazabicyclic Ring Structure: This unique bicyclic system may introduce additional factors affecting solubility, such as steric hindrance and electronic properties.
  • pH Sensitivity: Solubility may vary with pH; therefore, it's essential to consider the acidic or basic nature of the environment when assessing solubility.

In summary, the solubility of this compound is influenced by its structural features, including polarity, the presence of functional groups, and environmental conditions. Understanding these factors can provide insight into its potential applications and interactions in chemical processes.

Interesting facts

Interesting Facts about 1-[3-[3-(4-chlorophenyl)allyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]propan-1-one

This compound is a fascinating example of a synthetic organic molecule that exhibits unique structural features and potential biological activities. Here are some intriguing aspects of this compound:

  • Structural Complexity: The compound incorporates a bicyclic system known as diazabicyclo[3.2.1]octane, which is characterized by the presence of nitrogen atoms in its ring structure. This adds to its similarity to naturally occurring alkaloids.
  • Chlorophenyl Group: The presence of a 4-chlorophenyl group suggests potential interactions with biological targets, making it a candidate for pharmacological research. Chlorine atoms can significantly influence the lipophilicity and biological activity of compounds.
  • Allylic Modifications: The allylic component of this compound may enhance its reactivity and participation in various chemical transformations, allowing for diverse applications in synthesis.
  • Potential Applications: Compounds of this nature are of interest in medicinal chemistry, particularly in the development of new drugs that target specific receptors or pathways. They could also serve as scaffolds for the synthesis of novel therapeutic agents.
  • Research Interest: The structural characteristics and the presence of specific functional groups make this compound an interesting subject for research in areas such as neuropharmacology and toxicology.

The study of such compounds not only enriches our understanding of chemistry but also holds the promise for advancements in medical science. As a scientist, one might say, "Exploring the intricate designs of nature through synthetic chemistry provides endless possibilities for innovation and discovery."