Skip to main content

Nilutamide

ADVERTISEMENT
Identification
Molecular formula
C12H12FNO3
CAS number
63612-50-0
IUPAC name
1-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-allyl]-1-hydroxy-urea
State
State

At room temperature, Nilutamide is in a solid state. It is typically found in the form of tablets when used pharmaceutically.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
426.30
Boiling point (Kelvin)
699.45
General information
Molecular weight
317.32g/mol
Molar mass
317.3170g/mol
Density
1.3480g/cm3
Appearence

Nilutamide is typically a white to off-white crystalline powder. It may have no significant odor.

Comment on solubility

Solubility of 1-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-allyl]-1-hydroxy-urea

The compound 1-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-allyl]-1-hydroxy-urea, with the chemical formula C12H12FNO3, exhibits intriguing solubility characteristics. Understanding its solubility behavior is essential for applications in various fields, particularly in pharmaceutical formulations.

Factors Influencing Solubility

Several factors contribute to the solubility of this compound:

  • Presence of Functional Groups: The hydroxyl (-OH) and urea functional groups typically enhance solubility in polar solvents due to hydrogen bonding.
  • Hydrophobicity: The fluorophenoxy group introduces a degree of hydrophobic character, which may affect its solubility in aqueous environments.
  • Temperature: As with many compounds, increases in temperature can lead to increased solubility, allowing for better dispersion in solvents.

General Solubility Insights

When assessed, it's possible to consider the following:

  • Likely soluble in organic solvents, such as ethanol and DMSO due to its overall structural composition.
  • May exhibit limited solubility in water, primarily influenced by the compound's nonpolar regions.

“The solubility of a compound is not just a measure of its properties; it reflects its interactions with the solvent system.” Hence, comprehensively evaluating solubility is vital for the effective use of 1-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-allyl]-1-hydroxy-urea in practical applications.

Interesting facts

Interesting Facts about 1-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-allyl]-1-hydroxy-urea

This intriguing compound belongs to a class of chemicals known for their bioactivity, drawing considerable interest in the realms of medicinal chemistry and pharmaceutical research. Here are some notable aspects of this unique compound:

  • Pharmacological Potential: The structure of this compound, which includes a urea moiety, suggests possible applications in therapeutic formulations. Ureas are known to exhibit a variety of biological activities, making this compound a candidate for further investigation.
  • Fluorination Effect: The presence of the 4-fluorophenoxy group may enhance the compound's metabolic stability and lipophilicity, potentially improving its pharmacokinetic properties. Fluorine's unique ability to modify biological activity is a fascinating area of study.
  • Synthetic Pathways: The synthesis of such complex molecules often involves multiple steps of chemical transformations, showcasing the ingenuity and skill of synthetic chemists. Methods typically utilized can include nucleophilic substitutions and coupling reactions.
  • Research Applications: Compounds like this can serve as valuable tools in drug discovery, especially in screening programs that target specific biological pathways. Their diverse structures often allow for the exploration of new therapeutic angles.
  • Interdisciplinary Studies: This compound exemplifies the intersection of chemistry, biology, and pharmacology, emphasizing the importance of collaborative research efforts to unlock complex biochemical pathways.

Overall, 1-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-allyl]-1-hydroxy-urea represents a captivating topic for scientific inquiry, with the potential to lead to significant advancements in therapeutic strategies. As research continues to unveil the potential of such compounds, the journey from laboratory synthesis to clinical application illustrates the remarkable power of chemistry in addressing health challenges.

Synonyms
1-[4-[3-(4-fluorophenoxy)phenyl]but-3-en-2-yl]-1-hydroxyurea
KBioGR_000232
KBioSS_000232
KBio2_000232
KBio2_002800
KBio2_005368
KBio3_000463
KBio3_000464
Bio1_000390
Bio1_000879
Bio1_001368
Bio2_000232
Bio2_000712
HMS3267L21
DB-221532
Q27163571
N-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-N-hydroxy-urea