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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
1-[3-(5-nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone
State
State

At room temperature, nitrofurantoin is solid.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.20
Boiling point (Celsius)
465.20
Boiling point (Kelvin)
738.40
General information
Molecular weight
238.16g/mol
Molar mass
238.1570g/mol
Density
1.6800g/cm3
Appearence

Nitrofurantoin typically appears as a yellow crystalline powder.

Comment on solubility

Solubility of 1-[3-(5-nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone

The solubility of the compound 1-[3-(5-nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone can be intriguing due to its complex structure and unique functional groups. Generally, the solubility of organic compounds is influenced by their chemical structure, the presence of polar and non-polar regions, and their ability to form hydrogen bonds. Here are some points to consider:

  • Polar vs. Nonpolar: This compound contains both polar (nitro group, furan ring) and nonpolar (phenyl group) characteristics, which can affect its overall solubility in solvents.
  • Solvent Choice: It is likely to be soluble in polar organic solvents such as methanol, ethanol, and dichloromethane, while having limited solubility in nonpolar solvents like hexane due to the presence of polar functional groups.
  • Hydrogen Bonding: The presence of functional groups such as the carbonyl and nitro can also facilitate hydrogen bonding with solvent molecules, enhancing solubility in suitable polar solvents.

In summary, while precise solubility data may not be readily available for 1-[3-(5-nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone, its solubility is expected to be influenced by the interplay of its polar and nonpolar features, making it a compound of interest for further study in organic chemistry applications.

Interesting facts

Interesting Facts About 1-[3-(5-Nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone

1-[3-(5-Nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone, often referred to by its IUPAC name, is a fascinating compound that showcases the intricate world of heterocyclic chemistry. Here are some compelling characteristics that make this compound noteworthy:

  • Heterocyclic Structure: This compound includes an isoxazole ring, which is a five-membered ring containing both nitrogen and oxygen atoms. Heterocycles are significant in chemistry due to their vast applications in pharmaceuticals and agrochemicals.
  • Nitro Group Influence: The presence of a nitro group (–NO2) on the furan moiety not only enhances the compound's electrophilic properties but also makes it a potential candidate for studying biological activities such as antimicrobial and antiparasitic effects.
  • Pharmaceutical Potential: Compounds similar to this have been explored for their potential therapeutic uses, particularly in the field of drug development. They often exhibit various biological activities, which make them valuable in medicinal chemistry.
  • Research Interest: Chemists are particularly interested in the derivatives of such compounds for synthesizing new materials with enhanced properties, as well as studying their reactivity and mechanisms.

This compound serves as an excellent example of how structural variations can lead to significant differences in chemical properties and biological activities. As research continues, 1-[3-(5-Nitro-2-furyl)-5-phenyl-isoxazol-4-yl]ethanone may unveil even more secrets that could contribute to advancements in various scientific fields.

To quote a famous chemist, "Chemistry knows no boundaries; it dares to explore the darkest corners of the molecular realms." Embracing compounds like this allows us to push the boundaries of scientific knowledge.

Synonyms
KETONE, METHYL 3-(5-NITRO-2-FURYL)-5-PHENYL-4-ISOXAZOLYL
17960-21-3
BRN 0559616
Methyl 3-(5-nitro-2-furyl)-5-phenyl-4-isoxazolyl ketone
DTXSID90170842