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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
1-[3-(5-nitrotetrahydrofuran-2-yl)prop-2-enylideneamino]imidazolidine-2,4-dione
State
State

Nitrofurantoin is typically present as a crystalline solid at room temperature. The compound is stable under normal conditions but should be stored in a cool, dry place to prevent degradation and to maintain its efficacy when used as an antibacterial agent.

Melting point (Celsius)
259.50
Melting point (Kelvin)
532.65
Boiling point (Celsius)
338.40
Boiling point (Kelvin)
611.55
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6760g/cm3
Appearence

Nitrofurantoin appears as a light yellow crystalline powder. The compound can also exhibit an orange hue depending on the form, especially in its microscopic crystalline form. It is known to be odorless or exhibit a slightly bitter aroma when present in a more concentrated form.

Comment on solubility

Solubility of 1-[3-(5-nitrotetrahydrofuran-2-yl)prop-2-enylideneamino]imidazolidine-2,4-dione

The solubility of a compound is a critical property that influences its behavior and applications in various scientific fields. The solubility of 1-[3-(5-nitrotetrahydrofuran-2-yl)prop-2-enylideneamino]imidazolidine-2,4-dione can be considered based on several factors:

  • Polarity: The compound contains both polar and non-polar functional groups. This duality affects its solubility in various solvents.
  • Hydrogen Bonding: The presence of imidazolidine and nitro groups suggests the potential for hydrogen bonding, which can enhance solubility in polar solvents.
  • Size and Structure: The bulky tetrahydrofuran ring can hinder solubility due to steric effects, potentially limiting interaction with solvent molecules.

Generally, compounds similar in structure may exhibit solubility trends such as:

  1. Good solubility in polar protic solvents (e.g., water, alcohols) due to hydrogen bonding capabilities.
  2. Limited solubility in non-polar solvents (e.g., hexane, benzene) because of the polar character of the compound.

In summary, the solubility of 1-[3-(5-nitrotetrahydrofuran-2-yl)prop-2-enylideneamino]imidazolidine-2,4-dione is likely influenced by its unique structure and functional groups, leading to a complex interaction with solvents that warrants further investigation. To fully understand its solubility behavior, conducting empirical solubility tests in various solvents can provide valuable insights.

Interesting facts

Interesting Facts about 1-[3-(5-nitrotetrahydrofuran-2-yl)prop-2-enylideneamino]imidazolidine-2,4-dione

This compound, known for its complex structure and unique functional groups, presents intriguing opportunities for research and application in various fields. Here are some captivating insights:

  • Functional Group Diversity: The presence of multiple functional groups such as imidazolidine and nitrotetrahydrofuran gives this compound potential applications in medicinal chemistry. Its unique combination may influence biological activity and reactivity.
  • Synthetic Routes: The complexity of its structure suggests that synthesizing this compound may involve multi-step reactions, including steps such as nitration, alkylation, and amination. Researchers often explore different methodologies to achieve high yields and purities.
  • Potential Biological Activity: Compounds similar to this one have been investigated for their biological properties, including anti-cancer and anti-inflammatory effects. The nitro group is of particular interest, as it can participate in redox reactions, possibly leading to cytotoxic effects against cancer cells.
  • Interdisciplinary Applications: Beyond medicinal applications, its unique properties may find use in material science, especially in the development of polymers or other advanced materials due to its structural rigidity and multi-reactive potential.
  • Research Interest: Compounds of this nature often attract attention in the fields of pharmacology and organic synthesis. Their intricate structures demand innovative thinking and novel approaches to study their reactivity and interaction in biological systems.

As scientists continue to explore the potential applications and mechanisms of compounds like 1-[3-(5-nitrotetrahydrofuran-2-yl)prop-2-enylideneamino]imidazolidine-2,4-dione, they uncover new facets of chemistry that have the potential to impact medicine, materials science, and more. This compound serves as a prime example of how complexity in chemical structure can correlate with a wide range of biological activities.