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Asenapine dihydrochloride

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Identification
Molecular formula
C23H29N3O·HCl2·H2O
CAS number
1185887-21-1
IUPAC name
1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide;hydrate;dihydrochloride
State
State

At room temperature, asenapine dihydrochloride is typically in a solid state. This stable form is maintained under regular atmospheric conditions ensuring its usability in various chemical and pharmaceutical applications.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
425.54g/mol
Molar mass
426.5380g/mol
Density
1.3000g/cm3
Appearence

This compound typically appears as a white to off-white crystalline powder. Its hydrated form often influences its appearance, making it slightly more opaque compared to anhydrous forms. The dihydrochloride salt form ensures stability and solubility but does not significantly alter the natural appearance of the crystalline compound.

Comment on solubility

Solubility of 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide;hydrate;dihydrochloride

The solubility of a compound like 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide;hydrate;dihydrochloride can be influenced by several factors. Understanding these solubility characteristics is crucial for its application and bioavailability. Here are some key points to consider:

  • Hydration State: The presence of water molecules in the hydrate form can significantly enhance solubility in aqueous environments.
  • Ionization: As a dihydrochloride salt, the compound is likely to be ionized in solution, which typically increases solubility compared to its neutral form.
  • Polarity: The balance of hydrophobic (benzazepin and piperidine groups) and hydrophilic (carboxamide and chloride ions) components can affect solubility. Generally, more polar compounds have better solubility in water.
  • Temperature: Solubility can vary with temperature; typically, an increase in temperature leads to an increase in solubility for many solids.
  • pH Levels: The solubility of this compound can vary with pH, since ionization can be affected by the acidity or basicity of the solution.

In conclusion, while the specific solubility data for this compound is not provided, we can deduce that its solubility profile is likely to be favorable due to the combination of its hydrate form and dihydrochloride salt, enhancing its potential for use in pharmaceutical applications. Understanding these solubility characteristics is vital for optimizing formulation strategies and ensuring adequate bioavailability.

Interesting facts

Exploring 1-[3-(5,6-dihydrobenzob[1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide;hydrate;dihydrochloride

This compound is a fascinating subject of study due to its intricate structure and potential therapeutic applications. As a derivative of piperidine, it features fascinating elements such as:

  • Unique Structure: The compound comprises complex benzazepine and piperidine moieties, indicating potential interactions within biological systems.
  • Psychopharmacological Potential: Compounds with such multi-ring structures often exhibit significant psychotropic effects, making them interesting candidates for research in neuropharmacology.
  • Hydrate Form: The presence of water in its structure may influence the pharmacokinetics and stability, which is vital for its development as a drug.

Researchers often highlight the versatility of similar piperidine derivatives in drug design. As noted by scientists in the field, “The complex interplay of amine functionalities and aromatic systems in piperidine derivatives can lead to novel therapeutic agents.”

In the realm of pharmaceutical research, this compound can also be considered for:

  1. Analgesic Properties: Many piperidine derivatives have exhibited pain-relieving effects, and this compound might share those characteristics.
  2. CNS Activity: Given its structural traits, it may interact with central nervous system receptors, making it a vital subject for studying mood disorders.
  3. Potential Anti-cancer Activity: Some similar compounds are being investigated for their inhibitory effects on cancer cell lines.

As the search for effective treatments continues, the importance of compounds like 1-[3-(5,6-dihydrobenzob[1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide;hydrate;dihydrochloride cannot be overstated. Each investigation into its properties could pave the way for breakthroughs in medical science!

Synonyms
Carpipramine dihydrochloride
Defekton
Prazinil
Carpipramine hydrochloride
PZ 1511
PZ-1511
UNII-53X71X3I1W
53X71X3I1W
60452-13-3
Defekton (TN)
Defecton
Carpipramine dihydrochloride monohydrate
Carpipramine hydrochloride hydrate
CARBADIPIMIDINE HYDROCHLORIDE
Carpipramine HCl
Carpipramine hydrochloride hydrate (JAN)
CARPIPRAMINE HYDROCHLORIDE [MART.]
EINECS 230-372-1
CARPIPRAMINE HYDROCHLORIDE HYDRATE [JAN]
1'-(3-(10,11-Dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)-(1,4'-bipiperidine)-4'-carboxamide dihydrochloride monohydrate
CARPIPRAMINE DIHYDROCHLORIDE MONOHYDRATE [MI]
UNII-V073I10AA8
CARPIPRAMINE HYDROCHLORIDE (MART.)
CARPIPRAMINE DIHYDROCHLORIDE [MI]
(1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)-, dihydrochloride, monohydrate
ANHYDROUS CARPIPRAMINE HYDROCHLORIDE
CARPIPRAMINE DIHYDROCHLORIDE [WHO-DD]
CARPIPRAMINE DIHYDROCHLORIDE ANHYDROUS
ANHYDROUS CARPIPRAMINE HYDROCHLORIDE (MART.)
ANHYDROUS CARPIPRAMINE HYDROCHLORIDE [MART.]
1'-(3-(10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-5-YL)PROPYL)-(1,4'-BIPIPERIDINE)-4'-CARBOXAMIDE DIHYDROCHLORIDE
7075-03-8, anhydride
230-372-1
1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide;hydrate;dihydrochloride
CHEMBL3989549
DTXSID60991001
carpipramine dihydrochloride hydrate
D02713
Q27261139
1'-[3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboximidic acid--hydrogen chloride--water (1/2/1)