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Nefazodone

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Identification
Molecular formula
C25H32ClN5O
CAS number
83366-66-9
IUPAC name
1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide
State
State

At room temperature, Nefazodone is typically in a solid state, characterized by its crystalline structure. This makes it easy to handle and store under standard conditions.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
550.00
Boiling point (Kelvin)
823.15
General information
Molecular weight
470.67g/mol
Molar mass
470.6670g/mol
Density
1.2000g/cm3
Appearence

Nefazodone typically appears as a white to off-white crystalline powder. It may have a slight odor and is known for its sensitivity to light, especially when in powder form.

Comment on solubility

Solubility of 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide

The compound with the formula C25H32ClN5O exhibits a distinct solubility profile that can be influenced by several factors:

  • Polarity: Due to the presence of various functional groups, the compound can exhibit polar characteristics, which can aid in its solubility in polar solvents such as water and alcohol.
  • Hydrogen Bonding: The amide group within the structure can form hydrogen bonds, enhancing solubility in solvents that are capable of participating in hydrogen bonding.
  • Solvent Type: Typically, compounds like this tend to be more soluble in organic solvents such as DMSO or ethanol compared to water, indicating a hydrophobic characteristic due to the large hydrophobic portions of the molecular structure.
  • pH Dependency: The solubility may also change with pH, especially in biological environments, where the ionization of the amide could significantly affect solubility.

In summary, the solubility of this compound is influenced by its molecular complexity, functional groups, and the solvent's properties. Understanding these factors can be paramount for applications in drug formulation and delivery.

Interesting facts

Interesting Facts about 1-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(1-piperidyl)piperidine-4-carboxamide

This compound, with its complex name and unique structure, belongs to the class of benzodiazepines and plays a crucial role in medicinal chemistry.

Structural Features:

  • Benzazepine Structure: The presence of a benzazepine ring enhances its interaction with the central nervous system, potentially affecting mood and behavior.
  • Piperidine Moieties: The inclusion of piperidine groups suggests properties related to neurotransmitter modulation, which is significant in developing neuropharmacological agents.

Potential Applications:

  • This compound may have implications in treating disorders such as anxiety and depression.
  • Its analogs have been studied for their potential in managing neuropathic pain.

As a scientist, it’s fascinating to note how small changes in molecular structure can lead to vastly different pharmacological effects. The intricate balance of its components provides a rich area for research and development.

Research Insights:

  • Binding Affinity: Compounds like this often exhibit significant receptor binding, leading to various therapeutic effects.
  • Side Effects: Understanding the side effect profile is critical for safe medicinal use; hence, investigations into this compound's side effects are ongoing.

In summary, this compound encapsulates the beauty of complex organic chemistry, where its structure not only showcases the art of molecular design but also promises potential therapeutic avenues yet to be fully explored.

Synonyms
carpipramine
Carbadipimidine
5942-95-0
Carpipramina
Carpipramine [INN]
Bay b 4343 b
Carpipraminum
Carpipraminum [INN-Latin]
Carpipramina [INN-Spanish]
UNII-8AFK6F91EQ
EINECS 227-700-0
8AFK6F91EQ
BRN 0502521
Carpipramine (INN)
CARPIPRAMINE [MI]
Bay b 4343b
CARPIPRAMINE [WHO-DD]
1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide
DTXSID40208149
5-22-13-00540 (Beilstein Handbook Reference)
Carpipraminum (INN-Latin)
Carpipramina (INN-Spanish)
5-(3-(4-Piperidino-4-carbamoylpiperidino)propyl)-10,11-dihydro-5(H)-dibenz(b,f)azepine
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(4-piperidino-4-carbamoylpiperidino)propyl)-
1'-(3-(10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-5-YL)PROPYL)-(1,4'-BIPIPERIDINE)-4'-CARBOXAMIDE
Carpipramine (free base)
SCHEMBL34949
CHEMBL2110775
BDBM81794
DTXCID10130640
CHEBI:135729
NSC_2580
NCGC00522040-01
CAS_5942-95-0
NS00003620
D07623
L000953
Q2940145
227-700-0