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Gliclazide

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Identification
Molecular formula
C15H21N3O3S
CAS number
21187-98-4
IUPAC name
1-(3-amino-4-methyl-phenyl)sulfonyl-3-cyclohexyl-urea
State
State

Gliclazide is typically in a solid state at room temperature, where it is stable and easy to handle for compounding into medications.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
336.30
Boiling point (Kelvin)
609.45
General information
Molecular weight
323.41g/mol
Molar mass
323.4130g/mol
Density
1.3990g/cm3
Appearence

Gliclazide is a white to off-white crystalline powder that is odorless. The compound is often used in its powdered form for pharmaceutical preparations.

Comment on solubility

Solubility of 1-(3-amino-4-methyl-phenyl)sulfonyl-3-cyclohexyl-urea

The solubility of 1-(3-amino-4-methyl-phenyl)sulfonyl-3-cyclohexyl-urea is an important factor influencing its properties and applications. This compound exhibits variable solubility behavior due to its complex structure, which includes both polar and non-polar functional groups. Here are some key points regarding its solubility:

  • Polar Characteristics: The presence of the sulfonyl group (−SO2) and the amino group (−NH2) renders the compound somewhat polar, allowing it to dissolve in polar solvents like water to some extent.
  • Non-Polar Characteristics: The cyclohexyl group contributes to the hydrophobic nature of the compound, suggesting a preference for non-polar solvents, such as organic solvents like dichloromethane or ethanol.
  • pH Dependency: The solubility may also be influenced by pH levels; in acidic or basic conditions, the amino group could either be protonated or deprotonated, affecting the compound's overall polarity.
  • Complexity of Solvent System: Mixtures of solvents might be necessary to achieve a desirable solubility, as the balance of polar and non-polar characteristics need to be optimized for dissolution.

As a result, one could say, "The solubility of this compound is a delicate dance between its molecular structure and the chosen solvent." Understanding its solubility profile is crucial for its effective use in practical applications.

Interesting facts

Interesting Facts about 1-(3-amino-4-methyl-phenyl)sulfonyl-3-cyclohexyl-urea

1-(3-amino-4-methyl-phenyl)sulfonyl-3-cyclohexyl-urea is a fascinating compound primarily studied for its potential applications in medicinal chemistry. Below are some compelling aspects of this compound:

  • Pharmacological Potential: This compound may exhibit anti-inflammatory and antitumor activities, making it an essential component in the development of new therapeutic agents.
  • Designer Drug: Given its specific modifications, it serves as an example of a designer drug aimed at enhancing efficacy and reducing side effects in pharmacotherapy.
  • Amino Group Impact: The presence of the amino group plays a critical role in biological interactions, potentially influencing how the compound interacts with receptors or enzymes in the body.
  • Cyclohexyl Structure: The cyclohexyl moiety can significantly affect the lipophilicity of the molecule, affecting its absorption and distribution in physiological systems.
  • Sulfonyl Moiety: Compounds containing sulfonyl groups are often used in medicinal chemistry; this group can enhance the compound’s reactivity and increase its interaction with biological targets.

Researchers are continually exploring the implications of this compound in various fields such as pharmacology and drug design. Its complex structure and promising biological activities make it a subject of interest for further studies.

As this compound continues to be studied, it highlights the fascinating intersection of chemistry and biology and the ongoing quest for innovative therapeutic solutions.

Synonyms
Metahexamide
565-33-3
Glyhexylamide
Methahexamide
Methexamide
Metahexamida
Euglycin
Glyhexylamine isodiane
Metahexamidum
Metahexamidum [Latin]
Metahexamida [Spanish]
Hoechst 15972
Metahexamide [INN:BAN]
Metahexamidum [INN-Latin]
Metahexamida [INN-Spanish]
WP 40
EINECS 209-276-9
3-Amino-4-methylbenzenesulfonylcyclohexylurea
1-(3-Amino-p-tolylsulfonyl)-3-cyclohexylurea
BRN 2666352
Metahexamide (INN)
METAHEXANAMIDE
T3U6F5D722
D 970
S 1600
U 9970
METAHEXAMIDE [INN]
N-Cyclohexyl-N'-(3-amino-4-methylbenzenesulfonyl)urea
METAHEXAMIDE [WHO-DD]
Urea, 1-cyclohexyl-3-(4-methylmetanilyl)-
DTXSID3023267
Benzenesulfonamide, 3-amino-N-((cyclohexylamino)carbonyl)-4-methyl-
4-14-00-02779 (Beilstein Handbook Reference)
Metahexamidum (Latin)
Metahexamidum (INN-Latin)
Metahexamida (INN-Spanish)
DTXCID303267
A10BB10
3-(3-amino-4-methylbenzenesulfonyl)-1-cyclohexylurea
209-276-9
1-(3-amino-4-methylphenyl)sulfonyl-3-cyclohexylurea
Euglycin;Melanex;S-1600
3-amino-N-[(cyclohexylamino)carbonyl]-4-methylbenzenesulfonamide
Metahexamid
UNII-T3U6F5D722
SCHEMBL218071
CHEMBL507419
CHEBI:135328
XXYTXQGCRQLRHA-UHFFFAOYSA-N
GS4042
DB13675
DB-378686
NS00033536
D07117
Q6553356
3-amino-N-(cyclohexylcarbamoyl)-4-methylbenzenesulfonamide
2-amino-4-({[(cyclohexylamino)carbonyl]amino}sulfonyl)-1-methylbenzene