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Loxapine Dihydrochloride

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Identification
Molecular formula
C18H19ClN2O
CAS number
19819-05-9
IUPAC name
1-(3-benzo[b][1]benzazepin-11-ylpropyl)-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide;dichloride
State
State

At room temperature, loxapine dihydrochloride is typically in a solid state. It is important to store it in a dry place to prevent it from absorbing moisture due to its hygroscopic nature.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
412.80
Boiling point (Kelvin)
685.95
General information
Molecular weight
460.88g/mol
Molar mass
460.4340g/mol
Density
1.3300g/cm3
Appearence

Loxapine dihydrochloride typically appears as a white to off-white crystalline powder. It is known for its hygroscopic nature, which means it can absorb moisture from the air.

Comment on solubility

Solubility of 1-(3-benzo[1]benzazepin-11-ylpropyl)-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; dichloride

The solubility of 1-(3-benzo[1]benzazepin-11-ylpropyl)-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; dichloride is influenced by several structural and environmental factors. Given its complex molecular structure, we can infer some key points:

  • Polarity: The presence of multiple piperidine and carboxamide functional groups suggests the compound is likely to be polar, enhancing its solubility in polar solvents, such as water.
  • Hydrogen Bonding: The presence of carboxamide groups can form hydrogen bonds, facilitating interactions with solvent molecules and potentially increasing solubility.
  • Salt Formation: As a dichloride salt, this compound may exhibit improved solubility characteristics compared to its neutral form due to enhanced ionic interactions in polar media.
  • Concentration Dependency: The solubility might be influenced by factors such as temperature and saturation concentration, where an increase in temperature could lead to a higher solubility.

Additionally, it is important to note that solubility can vary significantly based on the formulation and the presence of either organic solvents or co-solvents. Therefore, experimental determination of the solubility in various solvents is crucial for practical applications.

In summary, while the potential for high solubility exists due to its polar nature and hydrogen-bonding capabilities, conclusive solubility data should be derived from targeted experiments.

Interesting facts

Exploring 1-(3-benzob[1]benzazepin-11-ylpropyl)-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; dichloride

This compound, with its intricate structure, represents an engaging intersection of organic chemistry and medicinal applications. As a member of the piperidine family, it combines unique cyclic elements that play a significant role in various biological activities due to its ability to interact with neurotransmitter systems.

Key Features:

  • Structural Complexity: The compound contains multiple rings and functional groups, which contribute to its potential reactivity and biological compatibility.
  • Medicinal Chemistry: Compounds of this nature are often explored for their pharmacological properties, especially in developing treatments for neurological disorders.
  • Ion Exchange: The presence of piperidinium ions can influence the solubility and stability of the compound, making it an interesting study subject for scientists examining drug formulation.

The saying goes, "The whole is greater than the sum of its parts," and this is particularly true for complex compounds like this one. When evaluating the effects of each functional group and ring structure, scientists are constantly uncovering new interactions and potential therapeutic applications.

Potential Applications:

  • Neurological studies, targeting serotonin and dopamine receptors.
  • Drug design for treating psychiatric and cognitive disorders.
  • Understanding synthesis pathways for analogous compounds.

In summary, 1-(3-benzob[1]benzazepin-11-ylpropyl)-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; dichloride serves as a fascinating example within chemical research, showcasing how intricate designs can lead to profound effects in biological systems. The ongoing exploration of such compounds expands our understanding of chemistry's role in medicine and highlights the importance of interdisciplinary studies.

Synonyms
28027-99-8
Isonipecotamide, 1-(3-(5H-dibenz(b,f)azepin-5-yl)propyl)-4-piperidino-, hydrochloride, hydrate (2:4:1)
RefChem:349714