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Clemastine

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Identification
Molecular formula
C21H26ClNO
CAS number
514-30-9
IUPAC name
1-(3-chloro-4-cyclohexyl-phenyl)cyclopropanecarboxylic acid;2-(dimethylamino)ethanol
State
State

At room temperature, Clemastine is in solid form. It manifests as a crystalline powder and is not typically considered volatile under standard conditions.

Melting point (Celsius)
97.50
Melting point (Kelvin)
370.65
Boiling point (Celsius)
252.00
Boiling point (Kelvin)
525.00
General information
Molecular weight
343.87g/mol
Molar mass
343.8670g/mol
Density
1.1789g/cm3
Appearence

Clemastine is typically encountered as a white or almost white crystalline powder. It is not particularly soluble in water, but it can be dissolved in alcohol and other organic solvents. The powder is usually odorless.

Comment on solubility

Solubility of 1-(3-chloro-4-cyclohexyl-phenyl)cyclopropanecarboxylic acid; 2-(dimethylamino)ethanol

The solubility of the compound 1-(3-chloro-4-cyclohexyl-phenyl)cyclopropanecarboxylic acid; 2-(dimethylamino)ethanol is influenced by several factors, including the presence of polar and non-polar functional groups in its structure.

Key Factors Influencing Solubility:

  • Polar Groups: The dimethylamino group present in the compound exhibits significant polarity, enhancing solubility in polar solvents, particularly water.
  • Hydrophobic Regions: The cyclohexyl and phenyl rings introduce hydrophobic characteristics, which can hinder solubility in highly polar environments.
  • Acidic Properties: The carboxylic acid component can ionize in appropriate pH conditions, which increases solubility in aqueous solutions through hydration of the ionized form.

In practical terms, the solubility of this compound can be summarized as follows:

  • In water: Moderate solubility is expected, particularly due to ionization effects of the carboxylic acid group.
  • In organic solvents: Better solubility can be anticipated in organic solvents like ethanol or acetone due to the interactions with hydrophobic portions of the molecule.

Quote to remember: "Like dissolves like." Therefore, in environments where the solvent has similar polarity to the functional groups of the compound, solubility will be enhanced.

Overall, the balance between polar and non-polar characteristics plays a crucial role in determining the solubility of this complex compound, making it a fascinating subject for further study.

Interesting facts

Interesting Facts about 1-(3-chloro-4-cyclohexyl-phenyl)cyclopropanecarboxylic acid; 2-(dimethylamino)ethanol

The compound combination of 1-(3-chloro-4-cyclohexyl-phenyl)cyclopropanecarboxylic acid and 2-(dimethylamino)ethanol represents a fascinating intersection of aromatic and aliphatic chemistry. This mixture showcases a unique blend of structural characteristics that can lead to varied chemical behaviors.

Key Features and Applications:

  • Cyclopropane Derivative: The cyclopropane ring structure offers interesting strain effects, impacting reactivity, and stability, which is crucial in syntheses and potentially influencing biological activity.
  • Chlorine Substitution: The presence of chlorine in the aromatic ring plays a significant role in the compound's reactivity and may enhance its lipophilicity, potentially affecting how this compound interacts in biological systems.
  • Dimethylamino Group: 2-(dimethylamino)ethanol introduces basic properties, making it a versatile compound especially in medicinal chemistry, where it may function as a potential intermediate in drug synthesis.
  • Pharmaceutical Potential: Compounds like this have been explored for various pharmaceutical applications, serving as bioactive agents with the potential to influence systems due to their unique structural properties.

A quote from an esteemed chemist captures the essence of such compounds: "The elegance of chemical design lies in the relationship between structure and function." This compound encourages the exploration of its applications in synthetic pathways and as a potential therapeutic agent.

Overall, the combination of these two components illustrates the beauty of organic synthesis and the endless possibilities within the realm of chemical research.

Synonyms
TAI 354
26961-96-6
DTXSID50181454
RefChem:336226
DTXCID60103945
1-(3-chloro-4-cyclohexylphenyl)cyclopropane-1-carboxylic acid;2-(dimethylamino)ethanol