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Etodolac

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Identification
Molecular formula
C17H20ClNO2
CAS number
41340-25-4
IUPAC name
1-(3-chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one
State
State

At room temperature, etodolac is a solid. It is usually encountered in the form of tablets or capsules for pharmaceutical applications.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
403.80
Boiling point (Kelvin)
676.95
General information
Molecular weight
287.79g/mol
Molar mass
287.7910g/mol
Density
1.2745g/cm3
Appearence

Etodolac appears as a white crystalline powder. It is odorless and slightly soluble in water, but soluble in alcohol and most organic solvents.

Comment on solubility

Solubility of 1-(3-chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one

The solubility of 1-(3-chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one can be characterized by a variety of factors that influence its behavior in different solvents. Generally, the solubility of organic compounds like this one is significantly affected by the presence of functional groups, structure, and molecular interactions.

In examining its solubility:

  • Polarity: The presence of the chloro group may enhance the compound's polarity, potentially making it more soluble in polar solvents such as water or alcohols compared to nonpolar solvents.
  • Hydrophobic Interactions: The aromatic ring and the alkyl chains contribute hydrophobic characteristics, which can limit solubility in polar environments.
  • Hydrogen Bonding: If the compound can form hydrogen bonds, this would increase solubility in polar solvents. However, the structural complexity may create steric hindrances that inhibit such interactions.

It is important to note that experimental data is essential for definitive conclusions about solubility. For instance, laboratory tests may reveal that this compound is:

  • Soluble in organic solvents like ethanol and acetone.
  • Partially soluble in water, depending on cultivation conditions and temperature.

Therefore, one must take into account the specific environmental conditions and solvent systems when predicting the solubility of 1-(3-chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one. Comprehensive solubility assessments can pave the way for application in various fields, such as pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 1-(3-Chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one

The compound 1-(3-chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one, often referred to in the scientific community by its systematic name, exhibits a fascinating profile of properties and potential applications. Here are some intriguing aspects:

  • Chemical Structure: This compound features a unique pyrrolidinone ring, which is significant in medicinal chemistry. The presence of the chloro and methyl groups on the phenyl ring enhances its reactivity and biological activity.
  • Medicinal Relevance: Compounds similar to this one are explored for their potential in pharmaceuticals, particularly as agents in the treatment of neurological disorders. Their ability to cross the blood-brain barrier makes them candidates for neuroprotective effects.
  • Analytical Importance: The distinctive substitution pattern of the ring system allows chemists to utilize various analytical techniques, such as NMR and mass spectrometry, to assess purity and structural integrity.
  • Research Interest: Due to its complex nature, it attracts interest in organic synthesis research. Chemists investigate its synthesis pathways, exploring ways to optimize yield and minimize side products.
  • Potential Therapeutics: There is ongoing research into its efficacy in treating conditions like anxiety and depression, making it a fascinating subject for pharmacological studies.

In the words of a renowned chemist, "The magic of chemistry lies in the connections between elements and the structures they form." This compound exemplifies that magic, showcasing how small modifications in structure can lead to significant changes in properties and functions.

The exploration of 1-(3-chloro-4-methyl-phenyl)-3-methyl-pyrrolidin-2-one not only enriches our understanding of organic compounds but also opens doors to innovative applications in medicine and materials science.

Synonyms
2884-69-7
1-(3-chloro-4-methylphenyl)-3-methylpyrrolidin-2-one
BV 207
DTXSID90951476
1-(3-CHLORO-4-METHYL-PHENYL)-3-METHYL-PYRROLIDIN-2-ONE
1-(3-Chloro-4-methylphenyl)-3-methyl-2-pyrrolidinone