Skip to main content

Flunarizine

ADVERTISEMENT
Identification
Molecular formula
C26H26ClN3O
CAS number
52468-60-7
IUPAC name
1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine
State
State

Flunarizine is typically in a solid state at room temperature.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
517.90
Boiling point (Kelvin)
791.05
General information
Molecular weight
404.96g/mol
Molar mass
404.0600g/mol
Density
1.0980g/cm3
Appearence

Flunarizine is typically observed as a white to off-white, crystalline powder. It is practically insoluble in water but freely soluble in chloroform, soluble in ethanol, and slightly soluble in ethyl acetate.

Comment on solubility

Solubility of 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine

The solubility of 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine is a complex topic that invites careful consideration of its molecular structure. Here are some key points related to its solubility:

  • Nature of the Compound: Due to the presence of both lipophilic (hydrophobic) and hydrophilic (hydrophilic) regions within its structure, solubility can vary significantly in different solvents.
  • Solvent Interaction: Typically, this compound is expected to be more soluble in organic solvents such as ethanol, chloroform, or DMSO, rather than in water. The lipophilicity of the alkyl and aromatic groups greatly influences this behavior.
  • Impact of Functional Groups: The presence of chlorine and piperazine moieties may enhance its ability to interact with polar solvents but can also hinder solubility in highly polar environments.
  • Temperature Affinity: Solubility may increase with temperature; thus, measuring solubility at different temperatures can provide useful insights.
  • Structural Considerations: Molecular weight and complexity can also play a crucial role, as larger molecules with bulky groups may exhibit reduced solubility due to steric hindrance.

As with many compounds of this nature, understanding the solubility characteristics is essential for applications in medicinal chemistry, environmental chemistry, and formulation studies. Therefore, conducting experiments under varied conditions is recommended to obtain a comprehensive profile of its solubility behavior.

Interesting facts

Interesting Facts about 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine

This complex compound belongs to a class of piperazine derivatives, which are known for their diverse biological activities. Here are some intriguing details about this compound:

  • Biological Significance: Piperazine derivatives are frequently researched for their pharmacological properties, including potential applications in treating disorders such as anxiety and depression.
  • Chlorine Substitution: The presence of the chlorine atom in the structure can significantly enhance the compound's binding affinity to various biological targets, often influencing its activity.
  • Structure Activity Relationships: This compound possesses multiple functional groups that may contribute to its activity and selectivity, highlighting the importance of structural modifications in medicinal chemistry.
  • Synthetic Challenges: The synthesis of such complex molecules often involves multi-step reactions, requiring precision and advanced techniques in organic chemistry.

To quote Sir Isaac Newton, "If I have seen further, it is by standing on the shoulders of giants." This highlights how understanding compounds like this one can pave the way for advancements in pharmacology and further scientific exploration.

In summary, 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine serves as a fascinating example of how organic synthesis and biological application are intricately linked in the field of chemistry.

Synonyms
TEROXALENE
14728-33-7
Teroxalene [INN]
teroxaleno
UNII-R4ZID09918
R4ZID09918
DTXSID40163643
1-(3-CHLORO-P-TOLYL)-4-(6-(P-TERT-PENTYLPHENOXY)HEXYL)PIPERAZINE
teroxalenum
DTXCID5086134
1-(3-chloro-4-methylphenyl)-4-[6-[4-(2-methylbutan-2-yl)phenoxy]hexyl]piperazine
1-(3-chloro-4-methylphenyl)-4-{6-[4-(2-methylbutan-2-yl)phenoxy]hexyl}piperazine
SCHEMBL1813607
CHEMBL2111143
MFCD00866734
AKOS001637283
NS00123285
SR-01000945127
SR-01000945127-1
Q27287798