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Alfuzosin Hydrochloride

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Identification
Molecular formula
C19H28ClN3O
CAS number
81403-68-1
IUPAC name
1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine;hydrochloride
State
State

At room temperature, Alfuzosin Hydrochloride is in a solid state, appearing as a crystalline substance.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
353.20
Boiling point (Kelvin)
626.35
General information
Molecular weight
389.91g/mol
Molar mass
389.9100g/mol
Density
1.0926g/cm3
Appearence

Alfuzosin Hydrochloride is an off-white to pale yellow crystalline powder, showing its solid form with a texture that is typical of many pharmaceutical compounds.

Comment on solubility

Solubility of 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine;hydrochloride

The solubility of the compound 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine;hydrochloride can significantly affect its application and effectiveness in various environments. Here are some key points about its solubility:

  • Nature of Solvent: This compound contains both hydrophilic (water-attracting) and hydrophobic (water-repelling) regions, which may suggest variable solubility in different solvents.
  • Hydrochloride Form: The hydrochloride salt form typically enhances water solubility compared to the base form of a compound, making this derivative more soluble in aqueous solutions.
  • Temperature Dependence: The solubility may also be influenced by temperature. Increasing temperatures often lead to increased solubility for most salts.
  • pH Sensitivity: As a piperazine derivative, solubility may vary with pH, showing higher solubility in acidic conditions due to protonation of the piperazine nitrogen.
  • Concentration Effects: The solubility can be affected by concentration; higher concentrations may lead to saturation, thus limiting further dissolution.

Understanding these factors is crucial in predicting the solubility behavior of this compound in different contexts, enabling more effective formulation and application strategies.

Interesting facts

Interesting Facts about 1-(3-chloro-4-methyl-phenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]piperazine; hydrochloride

This compound is a fascinating example of how chemical modifications can yield significantly different biological activities. Here are some key points that highlight its importance:

  • Pharmacological Relevance: This compound is often investigated for its potential therapeutic applications, particularly in the field of neuropharmacology. It's suggested that such compounds could play a role in the treatment of disorders related to the central nervous system.
  • Structural Diversity: Featuring a complex structure composed of various functional groups, it showcases the diversity possible in synthetic chemistry. The presence of both a piperazine ring and aromatic moieties can significantly influence the compound's pharmacological properties.
  • Chirality and Isomerism: Given the multiple chiral centers within its structure, this compound may exist in several stereoisomeric forms. This characteristic can affect its activity, including efficacy and side effects, making stereochemistry a vital consideration in drug development.
  • Environmental Impact: As with many synthetic compounds, it is crucial to evaluate the environmental implications of its use and degradation. Understanding how it behaves in biological systems and its potential ecological footprint is necessary for responsible research.

As scientists continue to explore compounds like this one, studying the intricate relationships between structure and activity remains a cornerstone of medicinal chemistry research. The ongoing investigation into such compounds fosters not only novel therapeutic avenues but also deepens our understanding of chemical interactions within biological systems.

Synonyms
TEROXALENE HYDROCHLORIDE
3845-22-5
Teroxalene HCl
PR-3847
Abbott 16612
Teroxalene hydrochloride [USAN]
UNII-LYL9ES50QE
A-16612
LYL9ES50QE
NSC-138704
A 16612
NSC 138704
Piperazine, 1-(3-chloro-4-methylphenyl)-4-(6-(4-(1,1-dimethylpropyl)phenoxy)hexyl)-, monohydrochloride
Teroxalene hydrochloride (USAN)
DTXSID50191770
1-(3-Chloro-p-tolyl)-4-(6-(p-tert-pentylphenoxy)hexyl)piperazine monohydrochloride
Piperazine, 1-(3-chloro-p-tolyl)-4-(6-(p-tert-pentylphenoxy)hexyl)-, monohydrochloride
1-(3-Chloro-p-tolyl)-4-[6-(p-tert-pentylphenoxy)hexyl]piperazine monohydrochloride
DTXCID90114261
Piperazine, 1-(3-chloro-p-tolyl)-4-(6-(p-tert-pentylphenoxy)hexyl)-, monohydrochloride (8CI)
1-(3-chloro-4-methylphenyl)-4-[6-[4-(2-methylbutan-2-yl)phenoxy]hexyl]piperazine;hydrochloride
SCHEMBL634903
CHEMBL2107539
NSC138704
AKOS024430088
PR 3847
D06079
Q27283260
Piperazine,1-dimethylpropyl)phenoxy]hexyl]-, monohydrochloride
1-(3-chloro-4-methylphenyl)-4-[6-(4-tert-pentylphenoxy)hexyl]piperazine hydrochloride
Piperazine, 1-(3-chloro-4-methylphenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]-, hydrochloride (1:1); Piperazine, 1-(3-chloro-4-methylphenyl)-4-[6-[4-(1,1-dimethylpropyl)phenoxy]hexyl]-, monohydrochloride (9CI); Piperazine, 1-(3-chloro-p-tolyl)-4-[6-(p-tert-pentylphenoxy)hexyl]-, monohydrochloride (8CI); A 16612; Teroxalene hydrochloride