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Clocortolone Pivalate

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Identification
Molecular formula
C17H15Cl2NO3
CAS number
882-09-7
IUPAC name
1-(3-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone
State
State

At room temperature, Clocortolone Pivalate is a solid, typically utilized in its powdered form for compounding into topical medications.

Melting point (Celsius)
102.00
Melting point (Kelvin)
375.15
Boiling point (Celsius)
493.30
Boiling point (Kelvin)
766.45
General information
Molecular weight
411.69g/mol
Molar mass
411.6890g/mol
Density
1.4230g/cm3
Appearence

Clocortolone Pivalate appears as a white to off-white crystalline powder. It is often finely ground to prepare for formulation in medicated creams and ointments.

Comment on solubility

Solubility of 1-(3-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone

The solubility of 1-(3-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone can be influenced by several factors due to its complex structure. Here are key points to consider:

  • Polarity: The presence of both hydrophilic (e.g., hydroxyl group) and lipophilic (e.g., chlorophenyl and dichloroacetyl groups) portions may lead to variations in behavior in different solvents.
  • Solvent Type: Generally, this compound is expected to have better solubility in polar organic solvents, such as dimethyl sulfoxide (DMSO) or ethanol, compared to nonpolar solvents.
  • Temperature Effects: Increasing the temperature can often enhance solubility, as it may provide sufficient energy to overcome the intermolecular forces holding the molecules together.
  • pH Influence: The solubility might vary with the pH of the solution, especially due to the ionization of the hydroxy group, which can have different states under acidic or basic conditions.

In summary, the solubility of this compound is not straightforward and can vary significantly depending on environmental conditions. Understanding the balance between its polar and nonpolar character is crucial for predicting its solubility in various environments. As noted, "the solvent can make all the difference" when it comes to effectively dissolving this intriguing chemical entity.

Interesting facts

Interesting Facts about 1-(3-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone

This fascinating compound is known for its intricate structure and potential applications in various fields, notably in medicinal chemistry. Here are some key points that make this compound interesting:

  • Antimicrobial Properties: This compound has shown promising activity against various microorganisms, making it a potential candidate for further research in the development of antimicrobial agents.
  • Complex Structure: The presence of multiple functional groups—including chloro and hydroxyl—enhances its reactivity, opening doors to various chemical transformations and derivatives.
  • Role in Drug Design: Compounds featuring both anilino and chloro groups are of particular interest in the pharmaceutical industry. They often serve as building blocks for synthesizing novel therapeutic agents.
  • Potential for Research: Due to its unique structure, this compound is an excellent subject for studies in drug metabolism, targeting mechanisms, and structure-activity relationships.
  • Environmental Considerations: With the presence of chlorine in its structure, understanding the environmental fate and toxicity of this compound is crucial in evaluating its safety for potential use.

To quote renowned chemist Linus Pauling, "The structure of a substance is of great importance in determining its reactivity and biological behavior." This compound exemplifies this principle, showcasing that its intricate arrangement can lead to significant biological implications. Overall, the exploration of 1-(3-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone remains a promising journey into the realms of chemistry and pharmaceuticals.

Synonyms
BRN 2772209
1-(3-Chlorophenyl)-2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxyethanone
27695-55-2
Ketone, 1-(3-chlorophenyl)-2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxy-
ETHANONE, 1-(3-CHLOROPHENYL)-2-((4-(DICHLOROACETYL)PHENYL)AMINO)-2-HYDROXY-
RefChem:341139
DTXSID00950359
1-(3-Chlorophenyl)-2-[4-(dichloroacetyl)anilino]-2-hydroxyethan-1-one