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Etomidate hydrochloride

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Identification
Molecular formula
C17H27ClN4O
CAS number
89708-65-0
IUPAC name
1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one;hydrochloride
State
State

At room temperature, Etomidate hydrochloride is typically in a solid state.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
343.20
Boiling point (Kelvin)
616.30
General information
Molecular weight
342.88g/mol
Molar mass
342.2420g/mol
Density
0.9200g/cm3
Appearence

Etomidate hydrochloride appears as a white to off-white crystalline powder. It is usually odorless and has a bitter taste, typical of many amine hydrochlorides.

Comment on solubility

Solubility of 1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one; hydrochloride

The solubility of the compound 1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one; hydrochloride is influenced by several factors, making it an interesting case study. Generally, hydrochloride salts are known for their improved solubility compared to their base forms. Here are some key points regarding its solubility:

  • Solvent Dependency: This compound is likely to be soluble in polar solvents such as water and alcohols due to the presence of the hydrochloride group, which can form hydrogen bonds with water molecules.
  • Temperature Influence: Like many compounds, solubility may increase with temperature, leading to greater dissolution in aqueous solutions under heated conditions.
  • pH Sensitivity: The solubility may also be pH-dependent; variations in the pH of the solution can affect the ionization of the amine groups, thus influencing overall solubility.

In summary, while 1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one; hydrochloride exhibits favorable solubility characteristics primarily due to its ionic nature, the specific conditions of solvent, temperature, and pH should be considered when predicting its solubility behavior.

Interesting facts

Interesting Facts about 1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one; hydrochloride

This compound is of great interest in the fields of medicinal chemistry and pharmacology due to its unique structural features and potential biological activity. Here are some key points to consider:

  • Structural Diversity: The imidazolidinone core of this compound allows for various substituents that can greatly influence its biological properties. The presence of the 3-chlorophenyl group plays a significant role in modulating its pharmacological effects.
  • Biological Activity: Compounds like this one are often investigated for their potential as neuroprotective agents or in treating psychiatric disorders due to the dimethylaminoethyl substituent, which is a common motif in many pharmaceuticals.
  • Synthetic Utility: The synthesis of such compounds involves intricate organic reactions that are of notable interest in synthetic organic chemistry. The incorporation of specific functional groups can lead to variations in activity and selectivity.
  • Research Focus: Ongoing research explores its role as a lead compound or scaffold for developing new drugs, especially in targeting specific receptors in the brain.

Moreover, the hydrochloride salt form of this compound often enhances solubility and bioavailability, making it a valuable form for drug formulation. In the words of a famous chemist, "The only thing more exciting than discovering a new compound is understanding the pathways it affects." With compounds like 1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one; hydrochloride, chemists hope to unlock new therapeutic avenues in medicine.

Synonyms
IMIDOLINE HYDROCHLORIDE
Imidoline HCl
5588-31-8
UNII-W82H9WE59K
Imidoline hydrochloride [USAN]
CL 48156
W82H9WE59K
CL-48156
Imidoline hydrochloride (USAN)
DTXSID70204477
1-(3-Chlorphenyl)-3-(2-dimethylaminoethyl)-2-imidazolidinon hydrochlorid
1-(m-Chlorophenyl)-3-(2-(dimethylamino)ethyl)-2-imidazolidinone monohydrochloride
2-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(dimethylamino)ethyl)-, monohydrochloride
2-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(dimethylamino)ethyl)-, hydrochloride
DTXCID70126968
1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]imidazolidin-2-one;hydrochloride
SCHEMBL122328
CHEMBL2105007
D02667
Q27292449
1-(3-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-2-imidazolidinone monohydrochloride