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3-Chlorophenylpiperazine hydrochloride

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Identification
Molecular formula
C10H14Cl2N2
CAS number
40541-09-9
IUPAC name
1-(3-chlorophenyl)piperazine;hydrochloride
State
State

At room temperature, 3-Chlorophenylpiperazine hydrochloride exists as a solid.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
214.00
Boiling point (Kelvin)
487.15
General information
Molecular weight
243.15g/mol
Molar mass
243.1540g/mol
Density
1.3500g/cm3
Appearence

3-Chlorophenylpiperazine hydrochloride is typically found as a white to off-white crystalline powder. It may appear slightly yellowish if impurities are present.

Comment on solubility

Solubility of 1-(3-chlorophenyl)piperazine; hydrochloride

1-(3-chlorophenyl)piperazine; hydrochloride is known for its unique solubility characteristics, which are influenced by its chemical structure. This compound displays the following solubility properties:

  • Soluble in Water: Due to the presence of the hydrochloride group, this compound tends to be highly soluble in water. This solubility is essential for its bioavailability in pharmaceutical applications.
  • Solubility in Organic Solvents: While it is primarily soluble in water, 1-(3-chlorophenyl)piperazine; hydrochloride may exhibit varying degrees of solubility in organic solvents such as ethanol and methanol. However, it is generally less soluble in non-polar solvents.
  • pH Dependence: The solubility of the hydrochloride salt can be affected by the pH of the solution, with higher solubility observed in acidic conditions. This may enhance its stability and effectiveness in solution.

In summary, the solubility of 1-(3-chlorophenyl)piperazine; hydrochloride is a critical factor in its functionality and effectiveness, especially in medicinal chemistry. As one source puts it, "A compound's solubility can significantly influence its pharmacokinetics and therapeutic outcomes." Understanding these solubility properties is paramount for any applications involving this compound.

Interesting facts

Interesting Facts About 1-(3-Chlorophenyl)piperazine Hydrochloride

1-(3-Chlorophenyl)piperazine hydrochloride is a fascinating chemical compound that belongs to the piperazine family. It has garnered attention in various fields, especially in medicinal chemistry and pharmacology due to its unique properties and applications.

Key Features:

  • Pharmacological Importance: This compound has been studied for its potential use as an antipsychotic medication. Its structure allows it to interact with various neurotransmitter receptors, making it a valuable candidate for treating psychiatric disorders.
  • Research Applications: Researchers utilize 1-(3-Chlorophenyl)piperazine hydrochloride in behavioral and neurological studies to understand its effects on the central nervous system, especially regarding anxiety and depression.
  • Structure-Activity Relationship (SAR): The modifications in its structure, such as the presence of a chlorine atom on the phenyl ring, can significantly impact its biological activity. This makes it a subject of interest for chemists looking to develop new drug analogs with improved efficacy.

Cultural References:

Interestingly, the derivative structure of piperazine has been referenced in various art and literature due to its connection with scientific advancements and drug development. As a notable example, piperazine compounds have been associated with the exploration of human psychology through literature, emphasizing the profound impact of chemistry on societal issues.

Quote by a Chemist:

As chemist and philosopher Julius von Mayer once stated, "In order to be a good chemist, one must learn to think as a chemist," emphasizing the importance of understanding molecular interactions which can lead to significant breakthroughs in medicinal applications.

In conclusion, 1-(3-Chlorophenyl)piperazine hydrochloride stands at the intersection of chemistry and medicine, driving innovation and research in understanding mental health conditions. The ongoing studies and applications will likely uncover even more intriguing aspects of this compound in the future.

Synonyms
1-(3-Chlorophenyl)piperazine hydrochloride
13078-15-4
65369-76-8
m-CPP hydrochloride
1-(M-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE
Piperazine, 1-(3-chlorophenyl)-, monohydrochloride
UNII-7IM2GS7ILV
1-(m-Chlorophenyl)piperazine HCl
7IM2GS7ILV
EINECS 235-976-9
EINECS 265-718-0
NSC-134746
Piperazine, 1-(m-chlorophenyl)-, monohydrochloride
DTXSID40896823
NSC 134746
PIPERAZINE, 1-(3-CHLOROPHENYL)-, HYDROCHLORIDE (1:1)
N-(3-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE
DTXCID801326291
235-976-9
265-718-0
1-(3-Chlorophenyl)piperazine monohydrochloride
1-(3-Chlorophenyl)piperazinium chloride
m-chlorophenylpiperazine hydrochloride
1-(3-chlorophenyl)piperazinehydrochloride
1-(3-chlorophenyl)piperazine;hydrochloride
1-(3-Chlorophenyl)-piperazine.HCl
(3-chlorophenyl)piperazine, chloride
Chlorophenyl Piperazine Hydrochloride Salt
SMR000875230
SR-01000075578
Chlorophenylpiperazinehydrochloride
Piperazine, 1-(3-chlorophenyl)-, hydrochloride
1-(3-Chlorophenyl)piperazine Monohydrochloride; 1-(m-Chlorophenyl)piperazine Monohydrochloride; 1-(3-Chlorophenyl)piperazine Hydrochloride; 1-(m-Chlorophenyl)piperazine hydrochloride; N-(3-Chlorophenyl)piperazine hydrochloride; m-CPP hydrochloride
MFCD00039032
1-(3-Chlorophenyl)piperazinedihydrochloride
MLS001332529
MLS001332530
MLS002153364
SCHEMBL264300
(3-chlorophenyl)piperazine HCl
CHEMBL1256321
NSC134746
SBB003261
3-chlorophenyl-piperazine hydrochloride
AKOS003851186
FC20352
LF-0568
1-(3-chlorophenyl)piperazine hydrocloride
AC-26324
BP-12386
PD019125
(3-chloro-phenyl)-piperazine hydrochloride
1-(3-chlorophenyl)-piperazine hydrochloride
DB-003846
DB-027257
A8874
ST50319817
1-(3-chloro-phenyl)-piperazine hydrochloride
F10604
1-(3-Chlorophenyl)piperazine hydrochloride, 99%
SR-01000075578-3
Q27268361
m-CPP HCl (1-(3-Chlorophenyl)piperazine Hydrochloride)
1-(3-Chlorophenyl)-piperazine.HCl, 1mg/ml in Methanol (as free base)
1-(m-Chlorophenyl)piperazine HCl;4-(3-Chlorophenyl)piperazine HCl;N-(3-Chlorophenyl)piperazine HCl
m-CPP HCl (1-(3-Chlorophenyl)piperazine Hydrochloride) 1.0 mg/ml in Methanol (as free base)