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Nitrazepam

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Identification
Molecular formula
C15H11N3O3
CAS number
146-22-5
IUPAC name
1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, Nitrazepam is in a solid state, typically found as a crystalline powder.

Melting point (Celsius)
227.50
Melting point (Kelvin)
500.65
Boiling point (Celsius)
393.50
Boiling point (Kelvin)
666.65
General information
Molecular weight
281.27g/mol
Molar mass
281.2730g/mol
Density
1.3080g/cm3
Appearence

Nitrazepam typically appears as a white to pale yellow crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one can be influenced by various factors, including its molecular structure, polarity, and the nature of the solvent used.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups, such as the nitro group, may enhance solubility in polar solvents.
  • Hydrogen bonding: The potential for hydrogen bonding interactions can significantly affect solubility in aqueous solutions.
  • Temperature: Generally, an increase in temperature can lead to higher solubility, especially for solid compounds.

Research indicates that compounds similar to this benzodiazepine derivative tend to have variable solubility:

  • In water: Often exhibits low solubility due to the hydrophobic character of the benzene rings.
  • In organic solvents: More soluble in solvents like ethanol or dimethyl sulfoxide (DMSO) owing to their ability to interact with non-polar regions of the molecule.

In conclusion, it's important to understand that while the solubility of 1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one may be limited in aqueous environments, it can be significantly improved in suitable organic solvents, making it pertinent to select the right solvent for optimal application.

Interesting facts

Exploring 1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one

1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one is a fascinating compound that belongs to the benzodiazepine family, widely known for their use in medicine as anxiolytics, hypnotics, and muscle relaxants. The unique structural features of this compound lend it specific properties and potential applications in various fields. Here are some interesting facts about this compound:

  • Pharmacological Insight: Benzodiazepines work primarily by enhancing the effect of the neurotransmitter GABA (gamma-aminobutyric acid), leading to increased inhibitory neurotransmission in the brain. This action can result in sedative and anti-anxiety effects, making compounds like this particularly valuable in clinical settings.
  • Dimethylamino Group: The presence of the dimethylamino group in the structure is significant as it can influence the bioavailability and potency of the compound, potentially improving its therapeutic effects.
  • Nitro Substitution: The nitro group at the 7-position adds to the compound’s chemical reactivity, potentially offering unique opportunities for further derivatization and the development of new pharmaceutical agents.
  • Applications in Research: Due to its complex structure and pharmacological properties, this benzodiazepine derivative is of interest in medicinal chemistry, notably in the development of new drugs aimed at treating anxiety disorders, epilepsy, and insomnia.
  • Structure-Activity Relationship (SAR): This compound serves as an excellent case study in SAR, allowing scientists to analyze how variations in molecular structure affect biological activity and therapeutic outcomes.

In summary, 1-[3-(dimethylamino)propyl]-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one is more than just a compound; it is a key player in ongoing research and development aimed at advancing our understanding of pharmacology and medicinal chemistry. Its unique components may lead to further discoveries in the realm of therapeutics.

Synonyms
CHEMBL315505