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Ketamine

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Identification
Molecular formula
C13H16ClNO
CAS number
6740-88-1
IUPAC name
[1-[3-(dimethylamino)propyl]pyrrol-2-yl]-(4-methoxyphenyl)methanone
State
State

At room temperature, ketamine is usually found as a solid, often in the form of a powder. However, it is frequently dissolved in solution for pharmaceutical applications. Therefore, it can also be encountered as a liquid, depending on its preparation and intended use.

Melting point (Celsius)
92.50
Melting point (Kelvin)
365.65
Boiling point (Celsius)
237.00
Boiling point (Kelvin)
510.15
General information
Molecular weight
237.34g/mol
Molar mass
237.3360g/mol
Density
1.0509g/cm3
Appearence

Ketamine is typically a white crystalline powder that can also be found in liquid form. The crystalline powder is composed of small, uniform crystals, often appearing fluffy or snow-like. In liquid form, it is colorless and appears clear.

Comment on solubility

Solubility of 1-[3-(dimethylamino)propyl]pyrrol-2-yl]-(4-methoxyphenyl)methanone

The solubility of 1-[3-(dimethylamino)propyl]pyrrol-2-yl]-(4-methoxyphenyl)methanone can be influenced by several factors, primarily due to its unique molecular structure. Generally, the solubility characteristics of this compound may be summarized as follows:

  • Polarity: As a molecule that contains both hydrophobic (the methoxy group and aromatic ring) and hydrophilic (the dimethylamino group) components, its solubility can vary significantly in different solvent environments.
  • Solvents: It is likely to exhibit higher solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetonitrile, while showing lower solubility in water due to its hydrophobic characteristics.
  • pH Sensitivity: The solubility may also be affected by the pH of the solution. Basic conditions can lead to increased solubility by protonation of the dimethylamino group, enhancing its interaction with polar solvents.
  • Temperature Effects: Increased temperature typically enhances solubility for many organic compounds, and thus, warm solutions might exhibit better dissolution rates compared to cold ones.

In conclusion, the solubility of this compound is not only determined by the solvent used but also by environmental conditions such as pH and temperature. Understanding these factors can aid in optimizing solubility for various applications, including pharmaceutical formulations and chemical reactions.

Interesting facts

Interesting Facts about 1-[3-(dimethylamino)propyl]pyrrol-2-yl-(4-methoxyphenyl)methanone

This compound, with its intricate structure, belongs to a class of chemical compounds known as pyrrole derivatives. Pyrrole itself is a five-membered aromatic ring that plays a crucial role in various biological systems. The presence of the dimethylamino group suggests potential interaction with biological receptors, making this compound of interest in medicinal chemistry.

Key Features

  • It features a pyrrol-2-yl moiety, which might enhance its ability to participate in various reactions.
  • The 4-methoxyphenyl substituent is known for its electron-donating properties, which can significantly influence the compound's reactivity and stability.
  • The overall structure reveals the potential for this compound to exhibit pharmacological activities, possibly involving neurotransmitter modulation.

In research settings, this compound can be utilized to explore structure-activity relationships in drug development. Its unique combination of functional groups may allow for multifaceted interactions with enzymatic pathways or receptor sites, elucidating new therapeutic avenues.

Potential Applications

  • Pharmaceutical development for mental health disorders
  • Research in neurochemistry
  • Studies related to receptor binding and molecular interactions

As scientists continue to explore the vast possibilities of pyrrole derivatives, compounds like 1-[3-(dimethylamino)propyl]pyrrol-2-yl-(4-methoxyphenyl)methanone exemplify the fusion of organic chemistry and biological science, paving the way for innovative solutions and discoveries.