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Meclozine

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Identification
Molecular formula
C25H31ON2
CAS number
569-65-3
IUPAC name
1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine
State
State

At room temperature, Meclozine is typically in a solid state. It is most often encountered as a dry powder, ideal for its common applications in the pharmaceutical industry.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
441.50
Boiling point (Kelvin)
714.65
General information
Molecular weight
390.58g/mol
Molar mass
390.5830g/mol
Density
1.0641g/cm3
Appearence

Meclozine typically appears as a white to off-white crystalline powder. It may vary slightly in hue depending on purity and specific formulation. The powder is usually fine and dry, suitable for compounding into various dosage forms.

Comment on solubility

Solubility of 1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine

The solubility of 1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine can be described as a complex interplay of factors due to its unique molecular structure. This compound, featuring both ethoxy and aromatic groups, presents interesting solvation characteristics.

Factors Affecting Solubility

In general, the solubility of this compound can depend on the following:

  • Polarity: The presence of polar ethoxy groups enhances solubility in polar solvents such as water, but the overall hydrophobic character of the aromatic rings may limit solubility.
  • Temperature: Increased temperature often facilitates greater solubility, making solvents like ethanol or dimethyl sulfoxide (DMSO) more effective in dissolving this compound.
  • pH Levels: The ionization of functional groups can significantly impact solubility in varying pH environments, particularly if under acidic or basic conditions.
  • Interactions with Solvents: The capability of the solvent to form hydrogen bonds or π-π interactions with the aromatic sections may enhance solubility.

Common Solvents

This compound is typically observed to be soluble in:

  • Organic solvents such as methanol and ethyl acetate.
  • Slightly soluble in water, often requiring co-solvents for enhanced dissolution.

Overall, the solubility of 1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine is a balance of its chemical properties and the solvent environment, making it a compound of interest for further studies in pharmacological applications and synthesis processes.

Interesting facts

Interesting Facts about 1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine

The compound 1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine is a fascinating example of a piperazine derivative, a class of compounds known for their versatile applications in medicinal chemistry. Here are some notable aspects:

  • Therapeutic Potential: This compound is primarily studied for its potential pharmacological effects, especially as a psychoactive agent. Piperazine derivatives have shown promise in treating various mental health disorders, making them valuable in drug development.
  • Chemical Structure: The compound features a piperazine ring, which is a six-membered structure containing two nitrogen atoms. This unique structure contributes to its biological activity and interactions with various receptors in the brain.
  • Substituent Diversity: The presence of ethoxy and m-tolyl groups highlights the importance of substituents in modifying the compound's behavior and properties. These groups can influence its biodistribution, metabolism, and overall efficacy.
  • Research Applications: Studies suggest that derivatives of this compound can be designed to selectively inhibit specific neurotransmitter reuptake, offering insights into the treatment of conditions such as depression and anxiety.
  • Example of Structure-Activity Relationship (SAR): This compound serves as an excellent case study for understanding SAR, as researchers can explore how varying the substituents impacts its biological activity.

As a student or researcher, understanding compounds like 1-(3-ethoxy-3-phenyl-propyl)-4-(m-tolyl)piperazine not only aids in the exploration of drug discovery but also enhances knowledge of structural chemistry and its applications in improving mental health therapies.


Synonyms
L6G2K736BK
1-(3-ethoxy-3-phenylpropyl)-4-(3-methylphenyl)piperazine
UNII-L6G2K736BK
1-(3-Ethoxy-3-phenylpropyl)-4-(3-tolyl)-piperazine
745-80-2
Piperazine, 1-(3-ethoxy-3-phenylpropyl)-4-(3-methylphenyl)-