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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
State
State

At room temperature, estrone is a solid substance.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
429.30
Boiling point (Kelvin)
702.45
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2390g/cm3
Appearence

Estrone appears as a white to off-white crystalline powder. It is typically odorless and is sensitive to light and air, which can cause it to degrade, thus it should be stored in a light-resistant container.

Comment on solubility

Solubility of 1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone (C18H22O2)

The solubility of the compound 1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone can be quite intriguing due to its complex structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of a hydroxyl group (-OH) suggests that the compound may have some polar characteristics, enhancing solubility in polar solvents such as water and alcohols.
  • Hydrophobic Influence: However, the large hydrophobic carbon chains and rings may hinder solubility in water, making the compound more soluble in non-polar solvents like hexane or chloroform.
  • Solvent Interaction: It is important to note that solubility can be influenced by temperature, pressure, and the specific solvent used.

In essence, the solubility of this compound remains complex, often exhibiting higher solubility in organic solvents while presenting challenges in aqueous environments. Factors such as concentration and political interactions with surrounding molecules can also significantly impact its solubility profile.

Interesting facts

Interesting Facts about 1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

This intriguing compound, known for its complex structure, is a part of the larger family of steroid-like molecules, which often play essential roles in biological systems. Here are some fascinating points about it:

  • Structural Complexity: The compound features a highly intricate arrangement of carbon atoms, showcasing a combination of hydroxy and carbonyl functional groups that contribute to its chemical behavior.
  • Biological Relevance: Compounds with similar structures are often explored for their potential effects on human health, including their role in hormone synthesis and regulation.
  • Synthesis and Derivatives: The synthesis of such compounds is a challenge that attracts chemists, as their derivatives could lead to novel pharmaceuticals with various therapeutic applications.
  • Research Significance: Due to its unique arrangement and functional groups, this compound could open avenues of research in medicinal chemistry, particularly in the exploration of anti-inflammatory and anti-cancer agents.
  • Potential Applications: Understanding its properties might lead to advancements in drug development, creating targeted therapies with fewer side effects.

As one explores the world of organic chemistry, compounds like this serve as a reminder of the vast creative potential inherent in molecular design. The interplay between structure, function, and biological activity remains a central theme in ongoing research, making this compound a significant focus for scientists in both synthetic and medicinal fields.

Synonyms
3-Hydroxypregn-5-en-20-one
1-{7-hydroxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl}ethan-1-one
.DELTA.5-Pregnenolone
5-Pregnen-3.beta.-ol-20-one
NSC1616
NSC-1616
Pregn-5-en-20-one, 3-hydroxy-
MFCD00003628
NSC-18158
Pregn-5-en-20-one, 3.beta.-hydroxy-
1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
SCHEMBL9926759
1-[(3S,8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-hydroxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
38372-24-6
LCA57454
NSC18158
BBL010646
STK801672
AKOS001642232
AKOS021994764
1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
1-[(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
AS-13783
FG109935
SY038298
DB-042772
EU-0007813
VU0059710-5
EN300-18277057
Z57387832
F3161-0035
(Gln22)-Amyloid b-Protein (1-40) trifluoroacetate salt
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe -Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-G ly-Leu-Met-Val-Gly-Gly-Val-Val-OH; H-DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV-OH