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Fosfomycin

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Identification
Molecular formula
C3H7O4P
CAS number
23155-02-4
IUPAC name
1-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridyl]methylamino]cyclopropanecarboxylic acid
State
State

At room temperature, Fosfomycin exists as a solid.

Melting point (Celsius)
93.50
Melting point (Kelvin)
366.65
Boiling point (Celsius)
95.30
Boiling point (Kelvin)
368.45
General information
Molecular weight
138.06g/mol
Molar mass
138.0590g/mol
Density
1.5240g/cm3
Appearence

Fosfomycin is a white crystalline powder. It is stable under normal conditions and does not have any color or distinct visual features.

Comment on solubility

Solubility of 1-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridyl]methylamino]cyclopropanecarboxylic acid

The solubility of the compound 1-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridyl]methylamino]cyclopropanecarboxylic acid (C3H7O4P) can be intriguing due to its complex structure and functional groups. Understanding its solubility can aid in various applications, including pharmacology and biochemistry. Here are a few points to consider:

  • Polar Functional Groups: The presence of hydroxyl (-OH), phosphonate (-PO3H2), and amino (-NH2) groups often indicates that the compound may exhibit good solubility in polar solvents, especially water.
  • Hydrophobic Characteristics: Conversely, the cyclopropanecarboxylic acid structure can provide some hydrophobic character, which may decrease its overall solubility in aqueous solutions.
  • Buffering Properties: Its acidic nature may result in enhanced solubility at varying pH levels, especially in buffered solutions.
  • Interactions with Solvent: The ability of this compound to form hydrogen bonds with water molecules could further contribute to its solubility.

In conclusion, while certain aspects of its structure suggest potential solubility challenges, the presence of polar functional groups strongly supports the idea that this compound can dissolve in water under appropriate conditions. Exploratory studies should quantify its solubility behavior across different solvents and pH levels for precise applications.

Interesting facts

Interesting Facts About 1-[[3-Hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridyl]methylamino]cyclopropanecarboxylic Acid

This unique compound, known for its complex structure, is an example of the innovative blends of organic chemistry and medicinal applications. Here are some fascinating insights:

  • Phosphono Group: The presence of the phosphono group in its structure makes it an intriguing candidate for biochemical studies, as phosphorus-containing compounds often participate in cellular processes and enzymatic reactions.
  • Medicinal Chemistry: Compounds like this one are of great interest in the development of pharmaceuticals, particularly in the search for new therapeutic agents that can effectively interact with biological targets, such as enzymes and receptors.
  • Cyclopropane Moiety: The cyclopropane ring adds a layer of strain that can significantly impact the reactivity and properties of the molecule, making it a subject of interest in synthetic organic chemistry.
  • Structure-Activity Relationship (SAR): Understanding how the structural features of this compound influence its biological activity can provide insights into designing more effective drugs or understanding molecular interactions in biological systems.

In summary, 1-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridyl]methylamino]cyclopropanecarboxylic acid serves as an excellent representation of how intricate chemical structures can yield compounds with significant implications in biochemical research and drug development. As the field of medicinal chemistry evolves, such compounds will undoubtedly play a pivotal role in shaping new therapeutic strategies.

Synonyms
N-PYRIDOXYL-1-AMINO-CYCLOPROPANECARBOXYLIC ACID-5-MONOPHOSPHATE
5PA
n-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-y-lmethyl]-1-amino-cyclopropanecarboxylic acid
1-(((3-hydroxy-2-methyl-5-((phosphonooxy)methyl)pyridin-4-yl)methyl)amino)cyclopropane-1-carboxylic acid
1-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopropane-1-carboxylic acid
SCHEMBL4312477
DB02849
1-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopropanecarboxylic acid
PD007585
NS00068882
Q27093811