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Glaucine

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Identification
Molecular formula
C21H25NO4
CAS number
55767-28-7
IUPAC name
1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
State
State

At room temperature, Glaucine is typically found in a solid state.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
684.00
Boiling point (Kelvin)
957.15
General information
Molecular weight
355.44g/mol
Molar mass
355.4140g/mol
Density
1.3820g/cm3
Appearence

Glaucine appears as yellow crystalline solid.

Comment on solubility

Solubility of 1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol

The solubility of 1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol can be influenced by several factors, including its molecular structure and the surrounding solvent environment. Typically, compounds with significant hydrophobic regions, such as this isoquinoline derivative, can exhibit limited solubility in polar solvents like water.

Key factors affecting solubility:

  • Molecular Structure: The presence of multiple methoxy and hydroxyl groups can impact the solubility characteristics. These functional groups can enhance solubility in polar solvents to some extent, yet the bulkiness of the isoquinoline ring may counterbalance this effect.
  • Solvent Type: Generally, organic solvents such as ethanol or DMSO may provide better solubilization due to their ability to interact with hydrophobic parts of the molecule.
  • pH Levels: The ionization state of the hydroxyl groups can also vary with pH, potentially increasing solubility in more alkaline conditions.

Overall, understanding the solubility profile of this compound is essential for its application in various pharmaceutical formulations and biological studies. As stated, "solubility is the gateway to bioavailability," stressing the importance of this property in drug design and delivery strategies.

Interesting facts

Overview of 1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol

This compound, often referred to in scientific literature, belongs to the class of isoquinolines. Isoquinoline derivatives have shown significant potential in various fields such as medicinal chemistry, particularly for their pharmacological properties.

Interesting Facts:

  • Indigenous Roots: Many isoquinoline derivatives are found in biological sources, including plants, which have been used in traditional medicine for centuries. This highlights the importance of natural compounds in drug discovery.
  • Pharmacological Activity: Compounds like this isoquinoline have been studied for their potential as:
    • Antioxidants
    • Antimicrobial agents
    • Anti-inflammatory compounds
  • Structure-Activity Relationships: The unique substituents in this compound, such as the methoxy and hydroxyl groups, play a crucial role in its biological activity. Understanding these relationships allows chemists to design better therapeutic agents.
  • Potential in Cancer Research: Some studies suggest that isoquinoline derivatives may have cytotoxic effects on cancer cells, making them targets for anti-cancer drug development.
  • Versatile Base for Synthesis: This compound’s structure provides a versatile platform for chemical modifications, which can lead to the development of even more potent derivatives through the introduction of different functional groups.

In summary, 1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol showcases the fascinating interplay between structure, activity, and natural origins. Exploring this compound further could yield exciting avenues for medicinal chemistry and the development of new therapeutic agents.

Synonyms
1699-46-3
Reticulin
1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
( inverted exclamation markA)-Reticuline
(RS)-Reticuline
Compound NP-025371
SCHEMBL147596
DTXSID10862010
DL-Reticuline;(+/-)-Reticuline
AKOS030627825
FR76329
HY-135489
CS-0113232
B2703-142898
1-[(3-Hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-, (S)-