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Acesulfame potassium

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Identification
Molecular formula
C4H4KNO4S
CAS number
55589-62-3
IUPAC name
1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(p-tolylsulfonyl)urea
State
State

At room temperature, Acesulfame potassium is a stable solid. It does not decompose under standard room temperature conditions and retains its crystalline form.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
780.00
Boiling point (Kelvin)
1 053.15
General information
Molecular weight
201.24g/mol
Molar mass
201.2400g/mol
Density
1.8100g/cm3
Appearence

Acesulfame potassium appears as a white crystalline powder. It is known for its high sweetness and is often used as a sugar substitute. The crystals are generally stable and can be easily dissolved in water.

Comment on solubility

Solubility of 1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(p-tolylsulfonyl)urea

The solubility of 1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(p-tolylsulfonyl)urea is influenced by various factors due to its complex structure. This compound may typically exhibit moderate solubility in polar solvents like water and alcohols, while being less soluble in non-polar solvents. It is essential to consider the following points regarding its solubility:

  • Hydrophilic characteristics: The presence of hydroxyl groups often enhances solubility in water, promoting interactions through hydrogen bonding.
  • Hydrophobic segments: The bulky norbornane structure and the sulfonyl group contribute to hydrophobicity, potentially limiting solubility in less polar environments.
  • Complex interactions: The balance between hydrophilic and hydrophobic components determines solubility behavior, making it subject to variation depending on the solvent system utilized.

In summary, the solubility of this compound is characterized by a dual nature. Its solubility can vary significantly across different solvents, highlighting the importance of solvent selection in applications and formulations.

Interesting facts

Interesting Facts about 1-(3-Hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(p-tolylsulfonyl)urea

This intriguing compound, often referred to as a sulfonamide derivative, boasts a unique structure that enhances its biological activity. Here are some fascinating aspects of this compound:

  • Diverse Applications: Compounds like this one have been studied for their potential in medicinal chemistry, particularly in drug development due to their ability to interact with biological systems effectively.
  • Sulfonamide Properties: The presence of the p-tolylsulfonyl group is noteworthy as sulfonamides are known for their antibacterial properties. This highlights the compound's significance in pharmaceutical research.
  • Structural Complexity: The norbornan core is a bicyclic structure that provides inherent stability and rigidity, making it an attractive scaffold for medicinal chemistry. The intricate arrangement of functional groups can lead to interesting physicochemical properties.
  • Bioactivity: Compounds with hydroxyl groups often display enhanced solubility and bioactivity, enabling them to interact more favorably with target sites within biological systems. This compound's configuration may suggest potential efficacy in therapeutic scenarios.
  • Potential Research Directions: This compound opens up avenues for research in various fields, particularly in areas focusing on drug design, selective inhibition of enzymes, and targeted therapeutics. Its unique structure is a gateway to discovering new biological activities.

In summary, 1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(p-tolylsulfonyl)urea is not just a compound with a complex name, but one that encapsulates the essence of innovation in chemical synthesis and medicinal applications. Its diverse properties and potential uses make it a subject of interest for ongoing research in chemistry and pharmaceutical sciences.

Synonyms
Gluboride
32609-19-1
Glutril (TN)
Glibornuride (USAN/INN)
SCHEMBL49696
CHEMBL4747108
DTXSID10865329
RMTYNAPTNBJHQI-UHFFFAOYSA-N
BCP13008
NS00002823
D02427
1-(2-Hydroxy-3-bornyl)-3-(p-tolylsulfonyl)urea
endo,endo-1-(2-Hydroxy-3-bornyl)-3-(p-tolylsulfonyl)urea
endo,endo-1-[(1R)-(2-Hydroxy-3-bornyl)]-3-(p-tolylsulfonyl)urea
1-[(1R,2R,3S,4S)-3-Hydroxy-4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]-3-(4-methylphenyl)sulfonylurea
Benzenesulfonamide, N-[[(3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]carbonyl]-4-methyl-, [1S-(endo,endo)]-