1-(3-hydroxyphenyl)-3-phenyl-isothiourea

Identification

Molecular formula

C₁₄H₁₄N₂OS

CAS number

2921-20-4

IUPAC name

1-(3-hydroxyphenyl)-3-phenyl-isothiourea

State

The compound is typically in a solid state at room temperature. It forms crystalline structures due to the interaction between the phenyl groups and isothiourea moiety.

Melting point (Celsius)

187.00

Melting point (Kelvin)

460.15

Boiling point (Celsius)

412.00

Boiling point (Kelvin)

685.15

General information

Molecular weight

258.33g/mol

Molar mass

258.3140g/mol

Density

1.3460g/cm³

Appearence

This compound appears as a crystalline solid. Its formation involves isothiourea groups, contributing to its distinct molecular structure. Due to its aromatic phenyl groups, it has properties typical of aromatic organic compounds, including potential for stability and specific reactivity based on its functional groups.

Comment on solubility

Solubility of 1-(3-hydroxyphenyl)-3-phenyl-isothiourea

The solubility of 1-(3-hydroxyphenyl)-3-phenyl-isothiourea in various solvents is an important aspect to consider in its application. This compound exhibits the following solubility characteristics:

Solvent-Specific Behavior: The solubility can significantly vary depending on the solvent used. Common solvents and their relative solubility include:

Aqueous solutions: Generally low solubility due to its aromatic structure.
Organic solvents (e.g., ethanol, methanol): Tends to have better solubility, making these solvents preferable for dissolving the compound.

Temperature Influence: Typically, the solubility increases with temperature, which is a common trait for many organic compounds.
Structural Factors: The presence of a hydroxyl group contributes to potential hydrogen bonding within the solvent, enhancing solubility in polar solvents.

In summary, while 1-(3-hydroxyphenyl)-3-phenyl-isothiourea may not be highly soluble in water, it shows improved solubility in organic solvents. This solubility behavior can be a crucial factor in its use in various chemical applications.

Interesting facts

Interesting Facts about 1-(3-Hydroxyphenyl)-3-phenyl-isothiourea

1-(3-Hydroxyphenyl)-3-phenyl-isothiourea is a fascinating compound that has gained attention in the realms of organic chemistry and pharmaceutical research. Here are some compelling insights into this intriguing molecule:

Functional Groups: This compound contains both an isothiourea group and a phenolic hydroxyl group, making it a versatile building block in the synthesis of various derivatives. The presence of these functional groups allows for a wide range of chemical reactivity.
Biological Significance: Research indicates that isothioureas have shown potential in medicinal chemistry, particularly due to their properties as enzyme inhibitors. This class of compounds is often explored for their potential anti-cancer and anti-inflammatory activities.
Research Applications: Compounds similar to 1-(3-hydroxyphenyl)-3-phenyl-isothiourea are frequently used in biological assays to study inhibition mechanisms, making them crucial in the development of new therapeutic agents.
Versatile Chemistry: The ability to modify the isothiourea moiety allows chemists to create potent analogs with improved biological properties, enhancing their pharmacological efficacy.
Historical Context: Isothioureas have a storied history in chemical research, having been first reported in the early 20th century. Their unique properties have intrigued scientists ever since!

In conclusion, 1-(3-hydroxyphenyl)-3-phenyl-isothiourea serves as an excellent example of how a seemingly simple compound can open doors to a multitude of applications, from synthetic organic chemistry to the exploration of new therapeutic avenues. Its functional complexity and potential for biological activity make it a valuable subject of study for both students and established researchers alike.