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Meclizine Hydrochloride

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Identification
Molecular formula
C21H25ClN2O3
CAS number
31884-14-5
IUPAC name
1-[3-methoxy-4-[4-(4-phenylpiperazin-1-yl)butoxy]phenyl]ethanone;hydrochloride
State
State

At room temperature, Meclizine Hydrochloride is typically in a solid state.

Melting point (Celsius)
134.50
Melting point (Kelvin)
407.60
Boiling point (Celsius)
370.10
Boiling point (Kelvin)
643.20
General information
Molecular weight
450.99g/mol
Molar mass
450.9880g/mol
Density
0.9876g/cm3
Appearence

The compound is usually found as a white to slightly yellow crystalline powder.

Comment on solubility

Solubility of 1-[3-methoxy-4-[4-(4-phenylpiperazin-1-yl)butoxy]phenyl]ethanone;hydrochloride

The solubility of 1-[3-methoxy-4-[4-(4-phenylpiperazin-1-yl)butoxy]phenyl]ethanone;hydrochloride is an important factor to consider in its chemical behavior and applications. The solubility characteristics of this compound can be highlighted through several points:

  • Solvent Compatibility: This compound is primarily soluble in polar solvents such as water and methanol, which can enhance its bioavailability and suitability for various biological applications.
  • pH Dependency: The solubility may significantly vary with changes in pH. Typically, the hydrochloride form indicates higher solubility in acidic conditions due to the ionization of the amine and the formation of charged species.
  • Temperature Influence: Like many compounds, its solubility often increases with temperature. Conducting solubility studies at different temperatures can provide valuable insight into its thermal stability.
  • Effect of Concentration: At higher concentrations, solubility can exhibit a tendency to plateau, indicating saturation, where the compound's ability to dissolve is maximized.

Understanding that:

“A compound's solubility can affect its pharmacokinetics and overall efficacy.”

is crucial in fields such as medicinal chemistry and pharmaceutical development. Overall, assessing the solubility profile of 1-[3-methoxy-4-[4-(4-phenylpiperazin-1-yl)butoxy]phenyl]ethanone;hydrochloride not only elucidates its chemical properties but also informs its practical applications.

Interesting facts

Interesting Facts about 1-[3-methoxy-4-[4-(4-phenylpiperazin-1-yl)butoxy]phenyl]ethanone;hydrochloride

This compound, commonly referred to simply as a halogenated derivative in the context of medicinal chemistry, is notable for its application as a potential therapeutic agent. It belongs to a class of molecules that are increasingly being explored for their neuropharmacological properties. Here are some intriguing insights:

  • Medicinal Properties: This compound is being studied for its potential mechanism of action on neurotransmitter systems, particularly in relation to conditions such as anxiety and depression.
  • Structural Complexity: The structure of the compound features a unique blend of a phenylpiperazine moiety, which is known for enhancing binding to serotonin receptors, and an ether component, increasing its lipophilicity.
  • Research Significance: As a part of ongoing research, derivatives like this one are essential for developing new therapies. The ability to manipulate the chemical structure can lead to compounds with improved efficacy and reduced side effects.
  • Pharmacological Exploration: The compound's interaction with various receptors in the brain has made it a focal point in studies related to antipsychotic medications and their mechanisms.
  • Potential for Synthesis Innovations: Organic synthesis techniques applied to compounds like this can provide new insights into modification strategies, leading to analogs with distinct biological activity.

As the understanding of brain chemistry evolves, compounds like this represent the frontier of research where chemistry meets pharmacology, and where understanding structure-activity relationships can lead to groundbreaking therapeutic developments. In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This sentiment rings true as researchers continue to explore the vast potentials inherent in structural diversity!

Synonyms
Su 14542
3439-67-6
Acetophenone, 3'-methoxy-4'-(4-(4-phenyl-1-piperazinyl)butoxy)-, monohydrochloride
SU-14542
DTXSID60187962
Ethanone, 1-(3-methoxy-4-(4-(4-phenyl-1-piperazinyl)butoxy)phenyl)-, monohydrochloride
3'-methoxy-4'-((4-phenyl-1-piperazinyl)butoxy)acetophenone hydrochloride
Ethanone, 1-[3-methoxy-4-[4-(4-phenyl-1-piperazinyl)butoxy]phenyl]-, monohydrochloride
DTXCID20110453
Ethanone, 1-(3-methoxy-4-(4-(4-phenyl-1-piperazinyl)butoxy)phenyl)-, monohydrochloride (9CI)
1-[3-methoxy-4-[4-(4-phenylpiperazin-1-yl)butoxy]phenyl]ethanone;hydrochloride
YH77W4C7HT
AKOS040754101
1-[3-Methoxy-4-[4-(4-phenyl-1-piperazinyl)butoxy]phenyl]ethanone hydrochloride
3'-Methoxy-4'[(4-phenyl-1-piperazinyl)-butoxy]-acetophenone monohydrochloride
3-METHOXY-4-(4-(4-PHENYL-1-PIPERAZINYL)-BUTOXY)ACETOPHENONE MONOHYDROCHLORIDE
Ethanone, 1-[3-methoxy-4-[4-(4-phenyl-1-piperazinyl)butoxy]phenyl]-, hydrochloride (1:1)