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3-Methyl-1H-indole-1-ethanone

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Identification
Molecular formula
C11H11NO
CAS number
38097-16-0
IUPAC name
1-(3-methylindol-1-yl)ethanone
State
State

At room temperature, 3-Methyl-1H-indole-1-ethanone is in a solid state. It can transition to a liquid state upon reaching its melting point, which is moderately low compared to other crystalline organic compounds.

Melting point (Celsius)
54.00
Melting point (Kelvin)
327.15
Boiling point (Celsius)
335.70
Boiling point (Kelvin)
608.85
General information
Molecular weight
173.22g/mol
Molar mass
173.2220g/mol
Density
1.1458g/cm3
Appearence

3-Methyl-1H-indole-1-ethanone is typically a crystalline solid. It may appear as pale yellow to off-white crystals or powder. The compound exhibits a characteristic odor, often compared to indole compounds, which is somewhat aromatic.

Comment on solubility

Solubility of 1-(3-methylindol-1-yl)ethanone

1-(3-methylindol-1-yl)ethanone, with the chemical formula likely reflecting its structural complexity, exhibits variable solubility characteristics. Understanding its solubility behavior is essential for applications in chemical synthesis and pharmaceuticals.

Solubility Characteristics:

  • Solvent Dependency: The solubility of this compound can significantly vary depending on the solvent used. Common solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) are often favorable.
  • Polarity Factors: Given its aromatic structure, 1-(3-methylindol-1-yl)ethanone likely shows a tendency to dissolve better in non-polar to moderately polar solvents.
  • Temperature Influence: As is typical for many organic compounds, increasing temperature can enhance solubility, making it more suitable for reactions at elevated temperatures.

It is often stated that “the solution to solubility is found in understanding the molecular interactions.” Thus, for 1-(3-methylindol-1-yl)ethanone, recognizing how it interacts with various solvents can provide insights into its processing and utility in different chemical contexts.

In summary, achieving a thorough understanding of the solubility of 1-(3-methylindol-1-yl)ethanone is crucial as it affects the compound's reactivity and application potential.

Interesting facts

Interesting Facts About 1-(3-methylindol-1-yl)ethanone

1-(3-methylindol-1-yl)ethanone, also known as a derivative of indole, holds significant importance in various fields of chemistry and biochemistry. Here are some intriguing insights about this compound:

  • Structural Significance: The presence of the indole ring—a bicyclic structure consisting of a benzene fused to a pyrrole—enriches its chemical properties. This unique structure allows for diverse interactions with biological systems.
  • Biological Relevance: Compounds derived from indole are well-known for their various biological activities. They can exhibit anti-cancer, anti-inflammatory, and anti-microbial properties, marking them as valuable targets in the development of pharmaceuticals.
  • Synthesis Enthusiasm: The synthesis of 1-(3-methylindol-1-yl)ethanone can be an exciting challenge for chemists. In particular, it typically involves approaches like the Friedel-Crafts acylation, which is a fundamental reaction in organic synthesis.
  • Flavor and Aroma: Some indole derivatives, including those related to 1-(3-methylindol-1-yl)ethanone, are known for their distinct scents. Indole itself can impart a floral or fecal aroma depending on concentration, showcasing its versatility in flavor chemistry.
  • Research Applications: The study of indole derivatives is a hot topic in medicinal chemistry. Their role in neurotransmission and modulation of certain dopamine receptors has sparked interest among researchers studying neurochemistry and psychology.

As the vast array of applications and properties associated with this compound continues to unfold, 1-(3-methylindol-1-yl)ethanone stands as a testament to the richness of organic chemistry and its pivotal role in drug discovery and development.


Synonyms
N-Acetyl-3-methylindole
23543-66-0
N-Acetylskatole
1-Acetyl-3-methylindole
INDOLE, 1-ACETYL-3-METHYL-
1-(3-methyl-1H-indol-1-yl)ethanone
D27BUG43N1
NSC-79240
RefChem:1054209
1-Acetylskatole
1-(3-methylindol-1-yl)ethanone
1H-Indole, 1-acetyl-3-methyl-
3-Methyl-1-acetyl-1H-indole
1-(3-Methyl-1H-indol-1-yl)ethan-1-one
NSC 79240
BRN 0127655
1-acetyl-3-methyl-1H-indole
NSC79240
1H-Indole, 1-acetyl-3-methyl- (9CI)
Ethanone, 1-(3-methyl-1H-indol-1-yl)-
UNII-D27BUG43N1
SKATOLE, 1-ACETYL-
5-20-07-00073 (Beilstein Handbook Reference)
SCHEMBL887129
SCHEMBL887130
DTXSID00178132
BWMWADPREVTFDJ-UHFFFAOYSA-N
WLN: T56 BNJ BV1 D1
AKOS004907510
HS-7027
1-(3-methyl-1H-indol-1-yl)-ethanone
DB-115808
InChI=1/C11H11NO/c1-8-7-12(9(2)13)11-6-4-3-5-10(8)11/h3-7H,1-2H