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Fenfluramine

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Identification
Molecular formula
C10H12F3N
CAS number
458-24-2
IUPAC name
1-[3-(trifluoromethyl)phenyl]propan-2-amine
State
State

At room temperature, Fenfluramine is a solid.

Melting point (Celsius)
94.00
Melting point (Kelvin)
367.15
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
233.26g/mol
Molar mass
233.2570g/mol
Density
1.0890g/cm3
Appearence

Fenfluramine appears as a white crystalline solid.

Comment on solubility

Solubility of 1-[3-(trifluoromethyl)phenyl]propan-2-amine

The solubility of 1-[3-(trifluoromethyl)phenyl]propan-2-amine can be influenced by several factors, primarily its unique structure, which incorporates a trifluoromethyl group. This group is known for its influence on the physical and chemical properties of organic molecules, particularly their interaction with solvents.

In general, the solubility of this compound can be summarized through a few key points:

  • Polarity: The presence of the highly electronegative fluorine atoms in the trifluoromethyl group may lead to increased polarity compared to similar hydrocarbons. This could facilitate solubility in polar solvents.
  • Hydrogen Bonding: The amine group in the molecule has potential for hydrogen bonding, which can enhance solubility in protic solvents, particularly those capable of donating hydrogen bonds.
  • Solvent Dependence: The solubility profile is likely to vary significantly depending on the solvent used. For example, it may be more soluble in organic solvents like ethanol or dimethyl sulfoxide than in non-polar solvents.
  • Temperature Effects: As with many organic compounds, solubility can increase with temperature, allowing for greater dissolution in solvents under heated conditions.

In conclusion, while further empirical studies would provide precise solubility values, it is reasonable to predict that 1-[3-(trifluoromethyl)phenyl]propan-2-amine shows a moderate to good solubility profile in polar solvents, especially considering its functional groups and molecular characteristics. Understanding the solubility behavior is crucial for applications in both research and industrial processes.

Interesting facts

Exploring 1-[3-(Trifluoromethyl)phenyl]propan-2-amine

1-[3-(Trifluoromethyl)phenyl]propan-2-amine, commonly referred to within the realm of organic chemistry, is a fascinating compound with distinctive properties and applications. Its structure comprises a phenyl group with a trifluoromethyl substituent, which significantly enhances its chemical behavior.

Key Characteristics:

  • Trifluoromethyl Group: The presence of the -CF3 moiety not only influences the compound's polarity but also enhances its stability, resistance to oxidation, and solubility in organic solvents.
  • Potential Applications: This compound is interesting in medicinal chemistry for the development of pharmaceuticals and agrochemicals due to the trifluoromethyl group's unique interactions.
  • Biological Activity: Compounds incorporating the trifluoromethyl group often exhibit enhanced biological activity, making them important in drug design. Research is ongoing into how this compound could fit into this trend.

In the words of a noted chemist, "The incorporation of fluorinated groups can transform the activity of a compound in unexpected and beneficial ways." This highlights the importance of examining compounds like 1-[3-(Trifluoromethyl)phenyl]propan-2-amine, as they can serve as critical building blocks in chemical synthesis and pharmaceutical development.

As our understanding of fluorinated compounds continues to grow, 1-[3-(Trifluoromethyl)phenyl]propan-2-amine stands out as an exciting candidate for further exploration in various scientific fields, particularly in the quest for novel therapeutic agents.

Synonyms
NORFENFLURAMINE
Norfenfloramine
Desethylfenfluramine
JP 92
dl-Norfenfluramine
1-(m-Trifluoromethylphenyl)-2-aminopropane
1-[3-(trifluoromethyl)phenyl]propan-2-amine
NSC 43036
1-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-2-AMINE
1-(3-Trifluoromethylphenyl)-2-amino propane
1-Methyl-2-(m-trifluoromethylphenyl)ethylamine
Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-
UNII-037A9J3PSW
1-(3-(Trifluoromethyl)phenyl)-2-propanamine
BRN 0392132
037A9J3PSW
alpha-Methyl-m-trifluoromethylphenethylamine
alpha-Methyl-3-trifluoromethylphenethylamine
Benzeneethanamine, .alpha.-methyl-3-(trifluoromethyl)-
Phenethylamine, alpha-methyl-m-trifluoromethyl-
NSC-43036
.alpha.-Methyl-3-(trifluoromethyl)phenethylamine
.alpha.-Methyl-m-(trifluoromethyl)phenethylamine
Phenethylamine, .alpha.-methyl-m-(trifluoromethyl)-
DTXSID60904717
JP-92
1-[3-(Trifluoromethyl)phenyl]-2-propanamine
2-AMINO-1-(3-(TRIFLUOROMETHYL)PHENYL)PROPANE
.ALPHA.-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE
(+-)-Norfenfluramine
alpha-Methyl-m-(trifluoromethyl)phenethylamine
DTXCID40811495
alpha-Methyl-3-(trifluoromethyl)phenethylamine
Phenethylamine, alpha-methyl-m-(trifluoromethyl)-
ALPHA-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE
(+-)-2-AMINO-1-(3'-TRIFLUOROMETHYLPHENYL)PROPANE
Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-(9CI)
mlbhfbkzuplwbd-uhfffaoysa-n
1886-26-6
(+/-)-norfenfluramine
NSC 43036;Desethylfenfluramine;JP 92
DESETHYL FENFLURAMINE
MFCD00671674
MFCD00671675
(plusmn)-norfenfluramine
SCHEMBL44927
GTPL215
CHEMBL1979333
BDBM86236
CHEBI:125411
NSC43036
CAS_15897
MFCD00871809
NSC_15897
AKOS000160966
AKOS022488710
MB01578
NCI60_003997
SY260392
SY297907
SY383219
1(3-tri-fluoromethylphenyl)2-aminopropane
1-(3-trifluoromethylphenyl)-2-aminopropane
DS-020573
NS00000645
.alpha.-Methyl-3-trifluoromethylphenethylamine
.alpha.-Methyl-m-trifluoromethylphenethylamine
EN300-141458
(R)-1-[3-(Trifluoromethyl)phenyl]-2-propanamine
(S)-1-[3-(Trifluoromethyl)phenyl]-2-propanamine
1-Methyl-2-[3-(trifluoromethyl)phenyl]ethylamine
L023994
Phenethylamine, .alpha.-methyl-m-trifluoromethyl-
1-Methyl-2-[3-(trifluoromethyl)phenyl]ethylamine #
Q3069482
BRD-A51916548-001-01-9
(+/-)-2-AMINO-1-(3'-TRIFLUOROMETHYLPHENYL)PROPANE
(alphaR)-alpha-Methyl-3-(Trifluoromethyl)-Benzeneethanamine