Cyclopentylpyrrol - Tosylurea | Solubility of Things

Identification

Molecular formula

C₁₈H₂₄N₂O₃S

CAS number

IUPAC name

1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(p-tolylsulfonyl)urea

State

At room temperature, this compound is in a solid state.

Melting point (Celsius)

130.50

Melting point (Kelvin)

403.65

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

357.45g/mol

Molar mass

357.4500g/mol

Density

1.3000g/cm³

Appearence

The compound is typically a crystalline solid, appearing as a white to off-white powder. Its crystalline structure may vary slightly depending on the specific conditions and method of crystallization used during synthesis.

Comment on solubility

Solubility Characteristics of 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(p-tolylsulfonyl)urea

The solubility of the compound 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(p-tolylsulfonyl)urea (C₁₈H₂₄N₂O₃S) can be assessed based on its structural features and functional groups. Here are some key points to consider:

Hydrophilicity vs. Hydrophobicity: The presence of a sulfonyl group contributes to the compound's hydrophilic characteristics, potentially aiding in solubility in polar solvents.
Functional Groups: The urea functional group often enhances solubility in water, while the aromatic and cyclic components might introduce hydrophobic interactions especially in non-polar solvents.
Solvent Compatibility: This compound may exhibit varying solubility across different solvents, typically showing higher solubility in polar solvents such as water or methanol, while being less soluble in non-polar solvents.

In practical terms, solubility can be crucial for applications in pharmaceuticals and chemical synthesis. As a general guideline, it's important to consider the following:

Solvent choice: Always test the compound in multiple solvents to identify the best conditions for solubility.
Temperature effects: Increasing the temperature may improve solubility for some compounds.
Concentration effects: Understand that solubility limits exist, and exceeding these can lead to precipitation.

To summarize, the solubility of 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(p-tolylsulfonyl)urea likely depends on solvent choice, temperature, and concentration, highlighting the essence of characterizing solubility for effective usage in various fields.

Interesting facts

Interesting Facts about 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(p-tolylsulfonyl)urea

This compound, often known for its complex structure and interesting applications in medicinal chemistry, showcases the fascinating interplay between organic compounds and biological activity. Here are some intriguing facts about it:

Pharmacological Potential: The unique structure of this compound lends itself to significant pharmacological properties. Its role as a potential therapeutic agent has made it a subject of interest in drug development research, particularly in targeting neurological disorders.
Structural Features: The cyclopentapyrrol structure contributes to its ability to traverse biological membranes, making it potentially effective in various therapeutic applications. Its hexahydro form increases stability, which is crucial for drug efficacy.
Application in Research: This compound is evident in studies exploring the inhibition of certain enzymes, indicating its potential role in treating diseases where enzyme dysfunction is a key factor.
Complex Synthesis: The synthesis of this compound requires advanced organic chemistry techniques. This complexity is a testament to the creativity and ingenuity involved in modern chemical synthesis, making it an engaging topic for chemistry students.
Collaborative Nature: The synthesis and characterization of such compounds often involve interdisciplinary collaboration among chemists, biochemists, and pharmacologists, highlighting the teamwork essential in scientific research.

The study of compounds like 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(p-tolylsulfonyl)urea not only broadens our understanding of chemical interactions but also paves the way for innovative therapeutic solutions in modern medicine.

Synonyms

gliclazide

21187-98-4

Glimicron

Gliclazida

Diamicron

Gliclazidum [INN-Latin]

Gliclazida [INN-Spanish]

Glimicron (TN)

Nordialex

CHEBI:31654

1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea

S-852

1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea

MFCD00409893

S-1702

DTXSID9023095

N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide

1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea

1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

NSC-758673

SE-1702

N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea

Gliclazidum

1-[(4-methylbenzene)sulfonyl]-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea

DTXCID003095

Glyclazide

Gliklazid

SE 1702

Benzenesulfonamide,N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-

J3.151H

S1702;SE1702

Gliclazidum (INN-Latin)

Gliclazida (INN-Spanish)

1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-[(4-methylphenyl)sulfonyl]urea

Gliclazide?

EINECS 244-260-5

Urea, 1-(hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)-

Urea, 1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)-

Diamicron MR

BRN 1657836

SMR000542971

GLICLAZIDE [MI]

GLICLAZIDE [INN]

GLICLAZIDE [JAN]

GLICLAZIDE (MART.)

GLICLAZIDE [MART.]

Benzenesulfonamide, N-(((hexahydrocyclopenta(c)pyrrol-2(1H)-yl)amino)carbonyl)-4-methyl-

Benzenesulfonamide, N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-

GLICLAZIDE [WHO-DD]

SR-01000816184

GLICLAZIDE (EP MONOGRAPH)

GLICLAZIDE [EP MONOGRAPH]

Gliclazide [INN:BAN:DCF:JAN]

Bilxona

Ziclaseg

Edicil

Glimil

Zicron

Vamju

Dacadis mr

Nazdol mr

Vitile xl

Zicron pr

1-((4-methylbenzene)sulfonyl)-3-(octahydrocyclopenta(c)pyrrol-2-yl)urea

NSC 758673

1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-((4-methylphenyl)sulfonyl)urea

Gliclazide,(S)

N-(hexahydrocyclopenta(c)pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide

NCGC00016751-01

Prestwick_869

CAS-21187-98-4

Gliclazide (Standard)

Gliclazide (Diamicron)

Spectrum_001478

SpecPlus_000870

Prestwick0_000558

Prestwick1_000558

Prestwick2_000558

Prestwick3_000558

Spectrum3_001862

Spectrum4_000598

Spectrum5_000753

Gliclazide (JP18/INN)

SCHEMBL16387

BSPBio_000635

BSPBio_003304

KBioGR_001096

KBioSS_001958

MLS001215197

MLS001304077

MLS001304118

DivK1c_006966

Gliclazide, powder, >=98%

SPECTRUM1504145

SPECTRUM1505013

SPBio_002556

BPBio1_000699

CHEMBL427216

N-((perhydrocyclopenta(c)pyrrol-2-yl)aminocarbonyl)-p-toluenesulfonamide

N-[(perhydrocyclopenta[c]pyrrol-2-yl)aminocarbonyl]-p-toluenesulfonamide

HY-B0753R

KBio1_001910

KBio2_001958

KBio2_004526

KBio2_007094

KBio3_002806

1-[3-Azabicyclo[3.3.0]oct-3-yl]-3-p-toluenesulfonylurea

A10BB09

Gliclazide (S1702; Diamicron)

HMS1569P17

HMS1922D15

HMS2090K16

HMS2096P17

HMS2855P09

HMS3656C22

HMS3713P17

HMS3744O13

Pharmakon1600-01504145

BCP21240

HY-B0753

Tox21_110590

BBL012275

BDBM50103512

NSC758673

NSC813216

s2601

STK803142

AKOS003237903

AKOS016340698

Tox21_110590_1

AB05958

CCG-213918

DB01120

FG23666

KS-1067

NSC-813216

N-[(hexahydrocyclopenta[c]pyrrol-2(1H)-ylamino)carbonyl]-4-methylbenzenesulfonamide

NCGC00095107-01

NCGC00095107-02

NCGC00095107-03

NCGC00095107-04

NCGC00095107-05

NCGC00095107-06

NCGC00095107-09

NCGC00095107-10

AC-12045

SBI-0052662.P002

AB00053165

G0381

NS00002064

SW196994-3

D01599

D83168

AB00053165-09

AB00053165_10

AB00053165_11

EN300-7359575

Q290001

SR-01000816184-2

SR-01000816184-3

SR-01000816184-4

BRD-A61154809-001-04-3

BRD-A61154809-001-14-2

BRD-A61154809-001-15-9

BRD-A61154809-001-16-7

Gliclazide, British Pharmacopoeia (BP) Reference Standard

Gliclazide, European Pharmacopoeia (EP) Reference Standard

1-(4-methylbenzenesulfonyl)-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea

N-((hexahydrocyclopenta[c]pyrrol-2(1H)-yl)carbamoyl)-4-methylbenzenesulfonamide

1-[3-Azabicyclo[3.3.0]oct-3-yl]-3-p-toluenesulfonylurea;Glimicron;N-[[(H exahydrocylopenta[c]pyrrol-2(1H)-yl]amino]carbonyl ]-4-methylbenzenesulfonamide

244-260-5

BENZENESULFONAMIDE, N-[[(HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YL)AMINO]CARBONYL]-4-METHYL