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Pimobendan

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Identification
Molecular formula
C19H18Cl2N4
CAS number
74150-27-9
IUPAC name
1-(3,4-dichlorophenyl)-2-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-pyrimidin-2-yl]guanidine
State
State

At room temperature, Pimobendan is typically found in a solid state as a crystalline powder.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
334.28g/mol
Molar mass
334.2090g/mol
Density
1.2850g/cm3
Appearence

Pimobendan typically appears as a pale, off-white to slightly yellow crystalline powder. It is not known to have any distinct odor.

Comment on solubility

Solubility Insights

The compound 1-(3,4-dichlorophenyl)-2-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-pyrimidin-2-yl]guanidine presents intriguing solubility characteristics that are important to comprehend.

Factors Influencing Solubility

This compound's solubility can be influenced by several factors:

  • Molecular Structure: The presence of multiple functional groups such as guanidine and piperidinyl can affect hydrogen bonding and polarity.
  • Polar and Non-polar Regions: The dichlorophenyl group is largely non-polar, while the guanidine moiety is distinctly polar, leading to a complex balance affecting solubility in various solvents.
  • pH of the Solution: As a guanidine derivative, its solubility might vary significantly with pH due to protonation states of the guanidine group.

Expected Solubility Behavior

Due to its structural complexity, one could expect:

  • Good solubility in polar solvents: such as ethanol or methanol, due to the presence of polar functional groups.
  • Limited solubility in non-polar solvents: indicating that it may not perform well in non-polar environments.
  • Highly variable solubility: which could change based on temperature and specific solvent conditions.

Overall, understanding the solubility properties of this compound is vital for its application and utility in various chemical and pharmaceutical contexts. As researchers delve more into its comprehensive solubility profile, we look forward to uncovering its potential in practical applications.

Interesting facts

Interesting Facts about 1-(3,4-Dichlorophenyl)-2-[4-[(1-Ethyl-3-Piperidyl)Amino]-6-Methyl-Pyrimidin-2-Yl]Guanidine

This intriguing compound is part of a class of compounds known for their diverse biological activities. Here are some fascinating points to consider:

  • Pharmaceutical Relevance: This compound is primarily studied for its potential as a therapeutic agent. Its unique structure allows it to interact with various biological targets, making it significant in medicinal chemistry.
  • Complex Structure: The presence of multiple functional groups, including a guanidine segment and a dichlorophenyl moiety, contributes to the compound's ability to form interesting interactions at the molecular level.
  • Mechanism of Action: Compounds like this often exhibit mechanisms that involve inhibition of specific enzymes or receptors, which are crucial in various physiological processes. Understanding these mechanisms can reveal how modifications in structure affect activity.
  • Role of Substituents: The incorporation of the piperidine ring and the substituted pyrimidine enhances solubility and binding capacity, showcasing how subtle changes in molecular structure can significantly impact pharmacological properties.

In the words of renowned chemists, *"The beauty of synthetic organic chemistry lies in the creativity to design molecules that can impact life profoundly."* This compound exemplifies that beauty and serves as a reminder of the vital intersection between chemistry and pharmaceuticals.

Whether through its development in drug discovery or its potential implications for treating diseases, 1-(3,4-dichlorophenyl)-2-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-pyrimidin-2-yl]guanidine stands as a testament to the innovation in chemical science.

Synonyms
1-(3,4-dichlorophenyl)-2-[4-[(1-ethylpiperidin-3-yl)amino]-6-methylpyrimidin-2-yl]guanidine
orb1739577
SCHEMBL2781115
SCHEMBL15539642
21062-28-2 (racemic)
DTXSID501030736
(+/-)-2-[3-(3,4-Dichlorophenyl)guanidino]-4-(1-ethyl-3-piperidylamino)-6-methylpyrimidine
1-(3,4-Dichlorophenyl)-2-{4-[(1-ethyl-3-piperidinyl)amino]-6-methyl-2-pyrimidinyl}guanidine