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3,4-Dichloroamphetamine

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Identification
Molecular formula
C9H11Cl2N
CAS number
2735-01-1
IUPAC name
1-(3,4-dichlorophenyl)propan-2-amine
State
State

At room temperature, 3,4-Dichloroamphetamine is primarily found in a solid state.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.20
Boiling point (Celsius)
265.50
Boiling point (Kelvin)
538.70
General information
Molecular weight
204.09g/mol
Molar mass
204.0930g/mol
Density
1.2290g/cm3
Appearence

3,4-Dichloroamphetamine is typically found as a crystalline solid. The appearance can vary from white to off-white crystals, and the solid form is usually quite pure when observed in a laboratory setting.

Comment on solubility

Solubility of 1-(3,4-dichlorophenyl)propan-2-amine

The solubility of 1-(3,4-dichlorophenyl)propan-2-amine, often referred to for its unique structural attributes, can vary significantly based on environmental conditions. Here are some key points to consider about its solubility:

  • Solvent Dependence: This compound typically demonstrates greater solubility in organic solvents such as ethanol and methanol compared to water. This is a common trait among amines and chlorinated compounds.
  • Temperature Effects: Increased temperature is likely to enhance solubility. For many organic compounds, elevated temperatures promote molecular movement, allowing for better dissolution.
  • pH Influence: The solubility may also be influenced by the pH of the solution. In acidic environments, the amine can become protonated, which may improve its solubility in water.
  • Structural Factors: The presence of the dichlorophenyl group enhances hydrophobic interactions, which generally reduces water solubility but increases affinity for lipid environments.

In summary, while 1-(3,4-dichlorophenyl)propan-2-amine shows limited solubility in aqueous solutions, its behavior in organic solvents can provide valuable insights for applications in various chemical processes. As stated, "solubility is a reflection of the interactions among solute, solvent, and temperature" which is essential for predicting its reactivity and usability in formulations.

Interesting facts

Interesting Facts about 1-(3,4-Dichlorophenyl)propan-2-amine

1-(3,4-Dichlorophenyl)propan-2-amine, commonly known in the scientific community as a substituted amphetamine, stands out due to its intriguing properties and potential applications. Here are some significant points to consider:

  • Structure and Substitution: This compound features a propan-2-amine backbone substituted with a dichlorophenyl group, indicating that chlorine atoms are strategically located at the 3 and 4 positions. This substitution plays a crucial role in influencing its pharmacological activity.
  • Pharmacological Interest: Compounds like this one are often studied for their psychoactive effects, particularly in relation to their use as stimulants or their potential role in treating attention-deficit hyperactivity disorder (ADHD).
  • Synthesis Pathways: The synthesis of this compound presents interesting challenges for organic chemists, as it may require specific reagents and conditions to achieve the desired substitution without unwanted side reactions.
  • Research Potential: Ongoing research into similar compounds could lead to significant discoveries in medicinal chemistry, especially regarding the development of new drugs that target neurological disorders.
  • Environmental Considerations: The presence of chlorine atoms in chemical compounds raises questions about environmental persistence and toxicity, making it crucial to understand the ecological impact of synthesis and accidental releases.

As a scientist or chemistry student, exploring the intricacies of 1-(3,4-dichlorophenyl)propan-2-amine opens doors to not only understanding its chemical behavior but also its potential therapeutic implications. The phrase "Every molecule has a story to tell," resonates deeply in this context as we continue unraveling the complexities of chemical compounds.

Synonyms
3,4-Dichloroamphetamine
1-(3,4-dichlorophenyl)propan-2-amine
4806-87-5
4Q81NBO3IA
CHEMBL48888
3,4-Dichlorophenyl-2-aminopropane
Lilly 21784
EINECS 225-366-0
Lilly-21784
3,4-Dichloro-alpha-methylphenethylamine
BRN 2803318
Phenethylamine, 3,4-dichloro-alpha-methyl-
UNII-4Q81NBO3IA
Benzeneethanamine, 3,4-dichloro-alpha-methyl-
Benzeneethanamine, 3,4-dichloro-.alpha.-methyl-
4-12-00-02623 (Beilstein Handbook Reference)
SCHEMBL3058411
DTXSID30896913
BDBM50176890
AKOS000161802
AKOS022488711
NCI60_042090
NS00045926
2-(3,4-Dichloro-phenyl)-1-methyl-ethylamine
N10880
3,4-DICHLORO-.ALPHA.-METHYLPHENETHYLAMINE
Q4634055
3,4-DICHLOROPHENYL-2-AMINOPROPANE, (+/-)-