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Galantamine hydrochloride

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Identification
Molecular formula
C17H22ClNO3
CAS number
1953-04-4
IUPAC name
1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydroisoquinolin-2-ium;chloride
State
State

At room temperature, Galantamine hydrochloride is in a solid state.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
368.86g/mol
Molar mass
368.8570g/mol
Density
1.3350g/cm3
Appearence

Galantamine hydrochloride typically appears as a white or almost white powder. It is crystalline in form, providing a distinct structure when examined under magnification.

Comment on solubility

Solubility of 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydroisoquinolin-2-ium;chloride

The solubility of 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydroisoquinolin-2-ium;chloride can be characterized based on its chemical structure and interactions with solvents. Generally, the presence of the quaternary ammonium ion suggests enhanced solubility in polar solvents.

Key points about its solubility include:

  • Solubility in Water: The chloride component typically increases solubility in water due to ion-dipole interactions.
  • Organic Solvents: The diethoxy groups enhance solubility in organic solvents such as ethanol and dichloromethane.
  • Temperature Dependence: Solubility may vary with temperature, with higher temperatures generally leading to increased solubility.
  • pH Influence: Changes in pH can affect the ionization state, altering solubility profiles in aqueous solutions.

In conclusion, the solubility of this compound exhibits a strong dependence on solvent polarity and environmental conditions, making it versatile for various applications.

Interesting facts

Interesting Facts about 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydroisoquinolin-2-ium;chloride

This fascinating compound belongs to a class of molecules known as *isoquinolines*, which display a broad range of biological activities and potential therapeutic properties. Here are some compelling facts to consider:

  • Pharmacological Potential: Isoquinolines are known for their diverse pharmacological profiles. They can exhibit anticancer, antibacterial, and anti-inflammatory activities, making them important subjects of study in medicinal chemistry.
  • Chemical Innovation: The introduction of diethoxy substituents enhances the solubility and stability of the compound, which can be crucial for its biological function and efficacy.
  • Structure-Activity Relationship (SAR): The unique structural features of this compound—including the isoquinoline core and ethoxy groups—allow researchers to investigate how variations in structure can affect biological activity, leading to the design of more potent derivatives.
  • Research Applications: Scientists are investigating isoquinoline derivatives for their roles in neuroprotection and cognitive enhancement, especially in the context of neurodegenerative diseases.
  • Synthesis Insights: The synthesis of this compound may involve complex multi-step processes, showcasing the challenges and rewards of organic synthesis in the lab. These methods often yield valuable insights into reaction mechanisms and functionalization strategies.

In summary, 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydroisoquinolin-2-ium;chloride is more than just a compound; it represents a rich field of research that bridges organic synthesis and pharmacology. The exploration of such compounds is crucial for advancing drug discovery and understanding the underlying mechanisms of disease.

Synonyms
911-60-4
Chlorhydrate de dihydroperparine
Chlorhydrate de dihydroperparine [French]
6,7-Diethoxy-1-(3,4-diethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride
ISOQUINOLINE, 3,4-DIHYDRO-6,7-DIETHOXY-1-(3,4-DIETHOXYBENZYL)-, HYDROCHLORIDE