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Ribavirin

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Identification
Molecular formula
C8H12N4O5
CAS number
36791-04-5
IUPAC name
1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide
State
State

Ribavirin is a solid at room temperature.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
244.21g/mol
Molar mass
244.2040g/mol
Density
1.6480g/cm3
Appearence

Ribavirin appears as a white or almost white, crystalline powder.

Comment on solubility

Solubility of 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide

The compound 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide, with the chemical formula C8H12N4O5, exhibits interesting solubility characteristics worthy of discussion.


Key Points on Solubility:

  • Polarity: Due to the presence of multiple hydroxyl groups and a carboxamide functional group, this compound is likely to be polar, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl (-OH) groups can engage in hydrogen bonding with water molecules, potentially increasing solubility further.
  • Structural Influence: The tetrahydrofuran moiety may contribute to its solubilizing properties, allowing it to interact favorably with aqueous systems.

Moreover, it is anticipated that the solubility could vary significantly depending on factors including temperature and pH of the solution. As a general observation, solubility of similar compounds often improves in slightly alkaline conditions, which is also worth considering when studying this compound’s applications.


To summarize, the solubility profile of this compound is influenced by both its functional groups and structural composition, likely rendering it soluble in water and other polar solvents, while allowing for interactions that could be utilized in various chemical applications.

Interesting facts

Interesting Facts about 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide

This compound, a member of the triazole family, presents intriguing possibilities in the field of medicinal chemistry. Here are some noteworthy aspects:

  • Bioactivity: Compounds with triazole moieties are often known for their antifungal, antibacterial, and antiviral activities. The presence of hydroxymethyl and dihydroxy groups enhances the potential for biological interactions.
  • Structural Versatility: The compound features a unique tetrahydrofuran ring, which can stabilize biological interactions through improved solubility and reactivity.
  • Research Potential: This specific triazole derivative has attracted attention for its potential applications in treating various diseases, often targeting enzyme inhibition mechanisms.
  • Pharmacophore Characteristics: The structural elements of this compound serve as a pharmacophore, indicating regions that can interact favorably with biological targets, a critical aspect in drug design.
  • Environmental Relevance: Understanding how such compounds behave in the environment is essential, as studies indicate that triazoles can have varying degrees of persistence and toxicity.

In summary, 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide embodies a fascinating blend of structural complexity and potential bioactivity, positioning itself as a compound of interest in both pharmaceutical research and environmental studies. Its combination of functionalities not only enhances its reactivity but also opens avenues for potentially groundbreaking therapeutic interventions.

Synonyms
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1192243-01-8
1-pentofuranosyl-1h-1,2,4-triazole-3-carboxamide
ICN 1229
Ribamide
1-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,2,4-triazole-3-carboxamide
NSC 163039
NCGC00015904-02
RTC
Rebetron (Salt/Mix)
CHEMBL34
1-.beta.-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
Oprea1_061838
SCHEMBL4064991
CHEBI:94463
DTXSID30860538
IWUCXVSUMQZMFG-UHFFFAOYSA-N
HMS3259D04
HMS3371C16
HMS3656E10
WQC81835
BBL005903
STK029646
STL454985
ZINC01035331
ZINC01091444
AKOS005380958
NC00688
NCGC00015904-05
NCGC00095898-01
SY055294
VS-01598
CS-0441880
EN300-49855
BRD-A96255180-001-01-2
Q27166325
1,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-
1-,beta,-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-pentofuranosyl-1H-1,2,4-triazole-3-carboximidic acid
1,2,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-
1-.beta.-D-Ribofuranosyl-1H-1,4-triazole-3-carboxamide
1H-1,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-
1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide