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Ribavirin

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Identification
Molecular formula
C8H12N4O5
CAS number
36791-04-5
IUPAC name
1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxy-imidazole-4-carboxamide
State
State

Ribavirin is in a solid state at room temperature.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
244.20g/mol
Molar mass
244.2040g/mol
Density
1.6487g/cm3
Appearence

Ribavirin typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxy-imidazole-4-carboxamide

The solubility of the compound 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxy-imidazole-4-carboxamide (C8H12N4O5) is an intriguing topic due to its unique structure and functional groups.

Key insights into its solubility include:

  • Polarity: The presence of multiple hydroxyl (–OH) groups contributes to the compound’s polarity, enhancing its ability to interact with water molecules.
  • Hydrogen Bonding: The compound can form hydrogen bonds, which are crucial for solubility in polar solvents like water.
  • Charge Consideration: The potential for ionization at physiological pH can further affect solubility; the imidazole structure may carry a charge that influences solubility in biological systems.
  • Solvent Interaction: It is expected to be more soluble in protic solvents compared to apolar solvents. This characteristic stems from the steric environment created by the carbohydrate-like moiety.

In summary, we anticipate that 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxy-imidazole-4-carboxamide demonstrates relatively good solubility in aqueous solutions due to its polar characteristics and ability to hydrogen bond. As always, specific solubility can vary with factors such as temperature and the presence of other solutes.

Interesting facts

Interesting Facts about 1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxy-imidazole-4-carboxamide

This compound, often referred to by its systematic name, showcases a fascinating combination of functional groups and structural motifs that are of great interest in the field of chemical science. Here are some intriguing aspects:

  • Biological Relevance: This compound is known for its biological activity, particularly in relation to metabolic processes. It serves as a precursor or a potential therapeutic agent in various biochemical pathways, reflecting its importance in medicinal chemistry.
  • Structural Complexity: The molecule contains both an imidazole ring and a carbohydrate derivative, which highlights the diverse functionalities in organic chemistry. Its unique configuration may influence its reactivity and interaction with biological targets.
  • Potential Applications: Scientists are exploring its application in drug development, especially in the treatment of conditions that involve oxidative stress, due to its antioxidant properties.
  • Research Insights: Studies have pointed out how the stereochemistry of the tetrahydrofuran ring affects the compound's biological activity. Such insights are invaluable for designing more effective pharmaceuticals.
  • Comparative Analysis: When compared to other compounds in its class, this compound often displays increased stability and a greater range of biological effects, making it a focal point for further research.

As we continue to unravel the complexity of chemical compounds, 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxy-imidazole-4-carboxamide stands out as a compelling example of how organic chemistry can intersect with biology, paving the way for innovative solutions in medicine.

Synonyms
NSC289637
NSC 289637;HE 69
5-hydroxy-1-pentofuranosyl-1h-imidazole-4-carboxamide
SCHEMBL7119
1H-Imidazole-4-carboxamide, 5-hydroxy-1-.beta.-D-ribofuranosyl-
CHEMBL165000
DTXSID30860619
HMS3372M17
HMS3869H13
AKOS015895934
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide
LS-13657
NCI60_002375