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Floxuridine

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Identification
Molecular formula
C9H11FN2O5
CAS number
50-91-9
IUPAC name
1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-fluoro-pyrimidine-2,4-dione
State
State

At room temperature, floxuridine is a solid.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.00
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.00
General information
Molecular weight
246.19g/mol
Molar mass
246.1920g/mol
Density
1.8520g/cm3
Appearence

Floxuridine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-fluoro-pyrimidine-2,4-dione (C9H11FN2O5)

The solubility of the compound 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-fluoro-pyrimidine-2,4-dione can be a nuanced topic due to its complex structure and various functional groups. Here are key points regarding its solubility:

  • Polar Functional Groups: The presence of several hydroxyl (-OH) groups and a fluorine atom generally suggests that the compound is likely to exhibit good solubility in polar solvents, such as water. This is due to the ability of these groups to form hydrogen bonds.
  • Hydrophobic Character: Despite its polar characteristics, some hydrophobic (water-repellant) regions might reduce solubility in very polar environments, making behavior in non-polar solvents (like hexane or toluene) less favorable.
  • Temperature Dependence: Solubility can also be temperature-dependent. Typically, an increase in temperature can enhance the solubility of most solids in liquids.

As a consequence of these factors, one might find that "this compound may exhibit moderate to good solubility in aqueous solutions, but limited solubility in non-polar organic solvents." It is vital in experimental settings to conduct solubility tests to evaluate its behavior in various solvents, especially when considering formulations or reactions.

Understanding the solubility of such complex molecules is crucial for their application in pharmaceutical and material sciences, where solubility can significantly affect bioavailability and overall efficacy.

Interesting facts

Interesting Facts about 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-fluoro-pyrimidine-2,4-dione

This compound represents a fascinating intersection of carbohydrate chemistry and nucleobase structure, combining elements that are essential in biological systems.

  • Bioactivity: 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-fluoro-pyrimidine-2,4-dione is noted for its potential bioactivity, particularly in medicinal chemistry where it may exhibit antiviral and anticancer properties.
  • Structural Features: The compound's structure features a pyrimidine ring, which is a key scaffold in many biologically active compounds, as well as a tetrahydrofuran moiety that can influence its biological interactions.
  • Fluorine Substitution: The presence of a fluorine atom is particularly interesting; fluorine can enhance the stability and lipophilicity of the compound, potentially improving its pharmacokinetic properties in biological systems.
  • Synthesis Challenges: The synthesis of this compound can be quite challenging due to the delicate balance of functional groups involved, with specific conditions needed to maintain the integrity of each component during synthesis.

As quoted by many chemists, "Chemistry is the art of manipulating molecules to create something unexpected." This compound serves as a perfect example of how intricate molecular designs can lead to novel compounds with promising biological applications.

Further studies into the mechanisms of action and potential therapeutic applications could reveal even more about this intriguing chemical, highlighting the interconnectedness of various fields within chemistry.