Skip to main content

Floxuridine

ADVERTISEMENT
Identification
Molecular formula
C9H11FN2O5
CAS number
50-91-9
IUPAC name
1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-pyrimidine-2,4-dione
State
State

At room temperature, Floxuridine is in the form of a solid, appearing as a powder. It needs specific storage conditions to maintain stability, often requiring a cool, dry place.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
361.80
Boiling point (Kelvin)
634.95
General information
Molecular weight
246.19g/mol
Molar mass
246.1910g/mol
Density
2.1870g/cm3
Appearence

Floxuridine appears as a white to off-white crystalline powder. It is often odorless and is slightly soluble in water and alcohol, making it useful in specific pharmaceutical formulations.

Comment on solubility

Solubility of 1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-pyrimidine-2,4-dione (C9H11FN2O5)

The solubility of a chemical compound is a crucial aspect that often dictates its applications and behavior in various environments. For the compound in question, the solubility can be influenced by several factors:

  • Polarity: The presence of hydroxyl groups in the structure increases polarity, suggesting that this compound may be soluble in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl groups can participate in hydrogen bonding, which further enhances solubility in aqueous solutions.
  • Fluorine Substitution: The fluorine atom can affect the compound's interactions with solvents, possibly influencing its overall solubility profile.

Numerous studies indicate that compounds similar to 1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-pyrimidine-2,4-dione typically demonstrate:

  1. Variable Solubility: While a degree of solubility is expected due to functional groups, the exact solubility may vary based on the presence of other substituents.
  2. pH Dependence: The solubility might also change with alterations in pH, which can affect the ionization state of the compound.

In conclusion, this compound's solubility characteristics emphasize the complexity of interactions at play. Thus, understanding these properties is vital for applications in pharmaceuticals and other fields where solubility plays a pivotal role in efficacy and performance.

Interesting facts

Interesting Facts about 1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-pyrimidine-2,4-dione

This compound, characterized by its unique structure and multifunctional properties, holds significant promise in various fields of research and application. Here are some intriguing facts about this interesting molecule:

  • Structural Diversity: The presence of both a pyrimidine and a tetrahydrofuran moiety in its structure contributes to its potential versatility in medicinal chemistry.
  • Fluorination Effects: The incorporation of fluorine in this compound can enhance its pharmacokinetic properties, making it a noteworthy candidate in drug design due to the stability and lipophilicity that fluorine imparts.
  • Biological Relevance: Compounds of this nature may exhibit enzyme inhibition activity or be involved in metabolic pathways, thus sparking interest among biochemists studying cellular processes.
  • Potential Therapeutic Applications: Given the dual functional roles of the hydroxyl groups and the fluoro-pyrimidine structure, there is potential for this compound to play a role as an anti-cancer agent or antiviral drug.
  • Research Implications: As a subject of ongoing research, insights gained from studying this compound can lead to advancements in synthetic methodologies and drug discovery.

In conclusion, the unique combination of functional groups in 1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-pyrimidine-2,4-dione opens doors to multifaceted exploration within scientific realms. As researchers continue to investigate its properties, the potential impacts on health and technology could be significant.

Synonyms
1-(5-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1h,3h)-dione
3094-09-5
Uridine, 5'-deoxy-5'-fluoro-
1-(3,4-dihydroxy-5-methyl-2-oxolanyl)-5-fluoropyrimidine-2,4-dione
Doxifluidine
MFCD00866530
SCHEMBL8095
CHEMBL6567
MLS006011761
CHEBI:93756
DTXSID60859793
HMS3369O10
HMS3655L13
BBL033967
STL373004
AKOS024282523
5-Fluoro-5'-deoxyuridine; Doxifluredine
NCGC00015450-02
NCGC00015450-03
NCGC00094834-01
NCGC00094834-02
LS-13622
SMR001223875
SY017052
5-Fluoro-5'-Deoxyuridine [3094-09-5]
5-Fluoro-5 inverted exclamation mark -deoxyuridine
Q27165447