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Norcocaine

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Identification
Molecular formula
C12H15NO3
CAS number
77-73-6
IUPAC name
1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone
State
State

At room temperature, norcocaine is in a solid state, generally appearing as a powder or crystalline substance.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
312.00
Boiling point (Kelvin)
585.15
General information
Molecular weight
267.33g/mol
Molar mass
267.3260g/mol
Density
1.3647g/cm3
Appearence

Norcocaine is a white crystal or crystalline powder. It is typically observed in a finely divided form and is known for its purity and colorless appearance when properly refined.

Comment on solubility

Solubility of 1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone

1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone is a fascinating compound that exhibits a distinctive solubility profile. Its solubility can be influenced by various factors, including pH, the presence of solvents, and temperature. Here are some key points to consider:

  • Polar Solvents: The presence of hydroxyl groups in the compound suggests that it may be soluble in polar solvents, such as water or ethanol. The ability of the hydroxyl groups to form hydrogen bonds likely enhances its solubility in these environments.
  • Nonpolar Solvents: Conversely, 1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone may have limited solubility in nonpolar solvents like hexane or benzene, due to the compound's polar functional groups.
  • Temperature Dependence: Solubility can also vary with temperature. An increase in temperature might improve the solubility of this compound in certain solvents, providing greater accessibility to reactive sites and enhancing interactions.
  • pH Sensitivity: The pH of the solution can significantly affect the ionization state of the molecule, which in turn can alter its solubility. In more acidic or basic environments, the solubility could increase or decrease depending on the degree of protonation or deprotonation of the hydroxyl or amine groups.

In summary, the solubility of 1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone is a complex interplay of its chemical structure and external conditions. Understanding these solubility characteristics is essential for effective applications in various fields such as pharmacology and bioengineering.

Interesting facts

Interesting Facts About 1-(3,4-Dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone

This compound, known for its interesting molecular structure, incorporates both a pyrrolidine and a phenolic group, suggesting a variety of interesting biological activities. Here are some noteworthy aspects:

  • Pharmacological Potential: Compounds with phenolic structures often exhibit a range of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. The presence of the pyrrolidine ring could enhance these biological effects through unique mechanisms of action.
  • Structure-Activity Relationship (SAR): The incorporation of the 3,4-dihydroxyphenyl group into the molecule provides valuable information for SAR studies. This could assist in the design of novel derivatives with improved potency and selectivity.
  • Applications in Drug Development: The compound may serve as a lead structure in synthesizing new drugs or therapeutic agents. Researchers could modify the molecular structure to explore its efficacy against various diseases.
  • Natural Origins: Similar compounds are often found in natural products, hinting at its potential presence in plants or other organisms. Studying such compounds can lead to the discovery of natural remedies.
  • Research Interest: Ongoing research might focus on the synthesis and characterization of this compound, providing insights into its pharmacokinetics and biological interactions.

As scientists explore the potential uses of 1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-ethanone, they are captivated by its capacity to bridge the realms of synthetic chemistry and pharmacology, opening the door to new advancements in medicinal science.

Synonyms
U 2956
BRN 0176968
ACETOPHENONE, 3',4'-DIHYDROXY-2-(1-PYRROLIDINYL)-
3',4'-Dihydroxy-2-(1-pyrrolidinyl)acetophenone
1-(3,4-Dihydroxyphenyl)-2-(1-pyrrolidinyl)ethanone
Ethanone, 1-(3,4-dihydroxyphenyl)-2-(1-pyrrolidinyl)-
DTXSID60168635
4-20-00-00184 (Beilstein Handbook Reference)
DTXCID2091126
Ethanone, 1-(3,4-dihydroxyphenyl)-2-(1-pyrrolidinyl)-(9CI)
16899-82-4
1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-ylethanone
1-(3,4-DIHYDROXYPHENYL)-2-(PYRROLIDIN-1-YL)ETHANONE
SCHEMBL6403309
AKOS008964192
AO-370/14522001